Extended knowledge of 63069-48-7

Some common heterocyclic compound, 63069-48-7, name is 4-Chloro-2-iodoaniline, molecular formula is C6H5ClIN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 63069-48-7

Step A: Preparation of l -Bromo-4-chloro-2-iodobcnzenc; |0892 ] A stirred mixture of coppcr(l l) bromide ( 1 1 mL, 237 mmol) in250 mL ACN at O0C was slowly treated with tert-butyl nitrite (33 mL, 276 mmol). The mixture was then warmed to 65C. and stirred for 30 minutes. The mixture was next treated dropwise with a mixture of 4-chloro-2-iodoaniline (50 g, 197 mmol) in 100 mL ACN. The resulting mixture was stirred for 1 hour. The mixture was cooled to room temperature and poured over 200 mL ice/10%HCl. The mixture was extracted with ether (3 x 100 mL). The combined organic layers were washed with I hO (2 100 m l .). 1 % ammonia water (2 x 100 niL), brine ( 100 ml), dried over anhydrous Na2SOi. and concentrated in vacuo to give 63 g brown oil as crude product. The crude product was purified by running it through a short silica plug eluting with 5% ether / hexane to give 54.2 g of the title compound as a yellow solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 63069-48-7, its application will become more common.

Reference:
Patent; AMGEN INC.; WO2008/76427; (2008); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com