Month: March 2021

Chemistry, like all the natural sciences, Product Details of 460-37-7, begins with the direct observation of nature¡ª in this case, of matter.460-37-7, Name is 1,1,1-Trifluoro-3-iodopropane, SMILES is ICCC(F)(F)F, belongs to iodides-buliding-blocks compound. In a document, author is Masuyama, Y, introduce the new discover.

syn-diastereoselective carbonyl allylation by 1-or 3-substituted prop-2-en-1-ols with tin(II) iodide and tetrabutylammonium iodide

1-Substituted or 3-substituted prop-2-en-1-ols cause syn-diastereoselective carbonyl allylation with tin(II) iodide and tetrabutylammonium iodide via the formation of 3-substituted prop-2-enylpolyiodotins to produce syn-1,2-disubstituted but-3-en-1-ols.

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Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 144-48-9, Name is 2-Iodoacetamide, molecular formula is C2H4INO. In an article, author is Eng, PHK,once mentioned of 144-48-9, Category: iodides-buliding-blocks.

Escape from the acute Wolff-Chaikoff effect is associated with a decrease in thyroid sodium/iodide symporter messenger ribonucleic acid and protein

In 1948, Wolff and Chaikoff reported that organic binding of iodide in the thyroid was decreased when plasma iodide levels were elevated (acute Wolff-Chaikoff effect), and that adaptation or escape from the acute effect occurred in approximately 2 days, in the presence of continued high plasma iodide concentrations. We later demonstrated that the escape is attributable to a decrease in iodide transport into the thyroid, lowering the intrathyroidal iodine content below a critical inhibitory threshold and allowing organification of iodide to resume. We have now measured the rat thyroid sodium/iodide symporter (NIS) messenger RNA (mRNA) and protein levels, in response to both chronic and acute iodide excess, in an attempt to determine the mechanism responsible for the decreased iodide transport. Rats were given 0.05% NaI in their drinking water for 1 and 6 days in the chronic experiments, and a single 2000-mu g dose of NaI ip in the acute experiments. Serum was collected for iodine and hormone measurements, and thyroids were frozen for subsequent measurement of NIS, TSH receptor, thyroid peroxidase (TPO), thyroglobulin, and cyclophilin mRNAs (by Northern blotting) as well as NIS protein (by Western blotting). Serum T-4 and T-3 concentrations were significantly decreased at 1 day in the chronic experiments and returned to normal at 6 days, and were unchanged in the acute experiments. Serum TSH levels were unchanged in both paradigms. Both NIS mRNA and protein were decreased at 1 and 6 days after chronic iodide ingestion. MS mRNA was decreased at 6 and 24 h after acute iodide administration, whereas NIS protein was decreased only at 24 h. TPO mRNA was decreased at 6 days of chronic iodide ingestion and 24 h after acute iodide administration. There were no iodide-induced changes in TSH receptor and thyroglobulin mRNAs. These data suggest that iodide administration decreases both NIS mRNA and protein expression, by a mechanism that is likely to be, at least in part, transcriptional. Our findings support the hypothesis that the escape from the acute Wolff-Chaikoff effect is caused by a decrease in NIS, with a resultant decreased iodide transport into the thyroid. The observed decrease in TPO mRNA may contribute to the iodine-induced hypothyroidism that is common in patients with Hashimoto’s thyroiditis.

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Synthetic Route of 88-67-5, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 88-67-5, Name is 2-Iodobenzoic acid, SMILES is O=C(O)C1=CC=CC=C1I, belongs to iodides-buliding-blocks compound. In a article, author is Hong, Jang-Hwan, introduce new discover of the category.

Two Carbonylations of Methyl Iodide and Trimethylamine to Acetic acid and N,N-Dimethylacetamide by Rhodium(I) Complex: Stability of Rhodium(I) Complex under Anhydrous Condition

Rhodium(I)-complex [Rh(CO)(2)I-2(-)] (1) catalyzed two carbonylations of methyl iodide and trimethylamine in NMP (1-methyl-2-pyrolidone) to acetic acid and DMAC (N,N-dimethylacetamide) in the presence of calcium oxide and water. The carbonylation of trimethylamine continued during the carbonylation and consumption of methyl iodide. In total, 183.8 mmol of carbonylated products was produced while consuming 24.1 mmol methyl iodide via acetic acid formation. These results clearly indicated that there were two carbonylation routes of trimethylamine and methyl iodide and the carbonylation rate of trimethylamine was faster than that of methyl iodide. Rhodium(I)-complex [Rh(CO)(2)I-2](-) (1) in the presence of trimethylamine was stable enough to be used 25 times with TON (Turnover Number) of 368 for DMAC and TON of 728 for trimethylamine. Inner-sphere reductive elimination in stepwise procedure was suggested for the formation of DMAC instead of acyl iodide intermediate under anhydrous condition.

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Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 144-48-9, Name is 2-Iodoacetamide. In a document, author is Vassaux, Georges, introducing its new discovery. Safety of 2-Iodoacetamide.

Iodinated Contrast Agents Perturb Iodide Uptake by the Thyroid Independently of Free Iodide

Perturbation of thyroid iodide uptake is a well-documented side effect of the use of iodinated contrast media (ICM) administered intravenously. This side effect is thought to be mediated by free iodide in ICM formulations, but this hypothesis has never been formally proven. The aim of the present study was to assess the validity of this hypothesis. Methods: We used mass spectrometry analysis to quantify free-iodide contamination in ICM. Established cell lines expressing the Na/I symporter (NIS) were used to quantify the effect of ICM on iodide uptake. SPECT/CT was used to measure the in vivo uptake of Tc-99m-pertechnetate and I-123 in 2 NIS-expressing mouse tissues, thyroid and salivary glands. Scintiscans of ICM-naive and ICM-administered patients were compared. Immunohistologic and Western blot analyses were performed to evaluate NIS protein expression in these organs. Results: Although free iodide was present in ICM formulations, in vitro uptake of iodide by NIS-expressing cells was not significantly affected by ICM. In mice, intravenous or sublingual administration of ICM led to a reduction in radiotracer uptake by the thyroid, accompanied by a dramatic reduction in NIS protein expression in this tissue. In the salivary glands, neither radiotracer uptake nor NIS protein expression was affected by ICM. The thyroid-selective effect of ICM was also observed in humans. Administration of potassium iodide as a source of free iodide led to a diminution of (99)mTc-pertechnetate uptake in both mouse thyroid and mouse salivary glands. Altogether, these data rule out a direct intervention of free iodide in the perturbation of thyroid uptake and suggest a direct and selective effect of ICM on the thyroid. Conclusion: We demonstrated that ICM reduce thyroid uptake of iodide independently of free iodide. This effect is due to a specific and dramatic decrease in NIS expression in thyrocytes. These data cast serious doubt on the relevance of measuring urinary iodide concentration to evaluate the delay between ICM administration and radioiodine therapy in patients with differentiated thyroid carcinoma. Finally, the ability of ICM to perturb iodide uptake in the thyroid may be used in radioprotection.

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Reference of 2043-57-4, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 2043-57-4, Name is 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodooctane, SMILES is ICCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F, belongs to iodides-buliding-blocks compound. In a article, author is Thapa, Surendra, introduce new discover of the category.

Copper-Catalyzed Negishi Coupling of Diarylzinc Reagents with Aryl Iodides

We report an efficient copper(I) iodide catalyzed cross-coupling of diarylzinc reagents with aryl iodides. The reaction proceeds under ligand-free conditions at low catalyst loading (5 mol%) and tolerates a variety of functional groups.

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One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 2043-57-4, Name is 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodooctane, formurla is C8H4F13I. In a document, author is Gervay-Hague, Jacquelyn, introducing its new discovery. HPLC of Formula: C8H4F13I.

Taming the Reactivity of Glycosyl Iodides To Achieve Stereoselective Glycosidation

Although glycosyl iodides have been known for more than 100 years, it was not until the 21st century that their full potential began to be harnessed for complex glycoconjugate synthesis. Mechanistic studies in the late 1990s probed glycosyl iodide formation by NMR spectroscopy and revealed important reactivity features embedded in protecting-group stereoelectronics. Differentially protected sugars having an anomeric acetate were reacted with trimethylsilyl iodide (TMSI) to generate the glycosyl iodides. In the absence of C-2 participation, generation of the glycosyl iodide proceeded by inversion of the starting anomeric acetate stereochemistry. Once formed, the glycosyl iodide readily underwent in situ anomerization, and in the presence of excess iodide, equilibrium concentrations of alpha- and beta-iodides were established. Reactivity profiles depended upon the identity of the sugar and the protecting groups adorning it. Consistent with the modern idea of disarmed versus armed sugars, ester protecting groups diminished the reactivity of glycosyl iodides and ether protecting groups enhanced the reactivity. Thus, acetylated sugars were slower to form the iodide and anomerize than their benzylated analogues, and these disarmed glycosyl iodides could be isolated and purified, whereas armed ether-protected iodides could only be generated and reacted in situ. All other things being equal, the beta-iodide was orders of magnitude more reactive than the thermodynamically more stable alpha-iodide, consistent with the idea of in situ anomerization introduced by Lemieux in the mid-20th century. Glycosyl iodides are far more reactive than the corresponding bromides, and with the increased reactivity comes increased stereocontrol, particularly when forming a-linked linear and branched oligosaccharides. Reactions with per-O-silylated glycosyl iodides are especially useful for the synthesis of a-linked glycoconjugates. Silyl ether protecting groups make the glycosyl iodide so reactive that even highly functionalized aglycon acceptors add. Following the coupling event, the TMS ethers are readily removed by methanolysis, and since all of the byproducts are volatile, multiple reactions can be performed in a single reaction vessel without isolation of intermediates. In this fashion, per-O-TMS monosaccharides can be converted to biologically relevant alpha-linked glycolipids in one pot. The stereochemical outcome of these reactions can also be switched to beta-glycoside formation by addition of silver to chelate the iodide, thus favoring S(N)2 displacement of the alpha-iodide. While iodides derived from benzyl and silyl ether-protected oligosaccharides are susceptible to interglycosidic bond cleavage when treated with TMSI, the introduction of a single acetate protecting group prevents this unwanted side reaction. Partial acetylation of armed glycosyl iodides also attenuates HI elimination side reactions. Conversely, fully acetylated glycosyl iodides are deactivated and require metal catalysis in order for glycosidation to occur. Recent findings indicate that I-2 activation of per-O-acetylated mono-, di-, and trisaccharides promotes glycosidation of cyclic ethers to give beta-linked iodoalkyl glycoconjugates in one step. Products of these reactions have been converted into multivalent carbohydrate displays. With these synthetic pathways elucidated, chemical reactivity can be exquisitely controlled by the judicious selection of protecting groups to achieve high stereocontrol in step-economical processes.

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In an article, author is Voronkov, M. G., once mentioned the application of 19094-56-5, Safety of 2-Chloro-5-iodobenzoic acid, Name is 2-Chloro-5-iodobenzoic acid, molecular formula is C7H4ClIO2, molecular weight is 282.46, MDL number is MFCD00079731, category is iodides-buliding-blocks. Now introduce a scientific discovery about this category.

Acyl iodides in organic synthesis: XI. Unusual N-C bond cleavage in tertiary amines

Acyl iodides reacted with excess primary and secondary amines in a way similar to acyl chlorides, yielding the corresponding carboxylic acid amide and initial amine hydroiodide. Reactions of tertiary amines with acyl iodides were accompanied by cleavage of the N-C bond with formation of the corresponding N,N-di(hydrocarbyl)carboxamide and alkyl iodide. In the presence of excess tertiary amine the latter was converted into quaternary tetra(hydrocarbyl)ammonium iodide.

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Synthetic Route of 19094-56-5, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 19094-56-5, Name is 2-Chloro-5-iodobenzoic acid, SMILES is O=C(O)C1=CC(I)=CC=C1Cl, belongs to iodides-buliding-blocks compound. In a article, author is Abdullah, AH, introduce new discover of the category.

Infrared reflection spectra of ammonium iodide at high pressure

IR reflection spectra for ammonium iodide at low temperature and at high pressure were used to study different stable phases of ammonium iodide and the transition regions between these stable phases. A modified Kramers-Kronig technique was used to analyze the reflection spectra. The IR reflection spectra of ammonium iodide at high pressure are reported here for the first time, and some of the new insights provided by this data, particularly for the transition regions are discussed.

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Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.19094-56-5, Name is 2-Chloro-5-iodobenzoic acid, SMILES is O=C(O)C1=CC(I)=CC=C1Cl, belongs to iodides-buliding-blocks compound. In a document, author is Skadauskiene, OP, introduce the new discover, Product Details of 19094-56-5.

Kinetic determination of iodide by the oxidation reaction of benzidine with chloramine B

A kinetic method was developed for the determination of iodides by their catalytic effect on the oxidation of benzidine with Chloramine B. The determination limit of iodide is 2 x 10(-4) mug/mL. it was demonstrated that the proposed method can be used for the determination of iodides in water, soil, and kelp.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 19094-56-5 is helpful to your research. Product Details of 19094-56-5.

Chemistry is an experimental science, Product Details of 60166-93-0, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 60166-93-0, Name is Iopamidol, molecular formula is C17H22I3N3O8, belongs to iodides-buliding-blocks compound. In a document, author is HUANG, TS.

IODIDE BINDING BY HUMIC-ACID

Iodide binding by humic acid was studied. The reaction was dose, temperature and pH dependent. A maximum binding of 88% was reached with 2 mg humic acid in 0.15 M Tris buffer. The efficiency of iodide binding by the buffer becomes higher whenever the buffer is slightly alkaline. Iodide binding by humic acid at 60-degrees-C is more efficient than that at room temperature or 4-degrees-C. The reaction was very rapid and reached equilibrium in 2 h. There are two binding sites for iodide in humic acid. The iodide binding by humic acid is inhibited by depletion of oxygen. The reaction was also inhibited by superoxide dismutase, catalase, thiourea, glutathione and dithiothreitol, but butylated hydroxytoluene and ascorbic acid did not inhibit it. In conclusion: (a) Humic acid can bind iodide efficiently in various buffers, (b) the binding is probably a reaction of oxidation reduction, (c) free radicals are involved in the reaction and (d) free radicals are present in the humic acid.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 60166-93-0, in my other articles. Product Details of 60166-93-0.