Month: March 2021

Reference of 450412-29-0, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 450412-29-0, Name is 1-Bromo-3-fluoro-2-iodobenzene, SMILES is FC1=CC=CC(Br)=C1I, belongs to iodides-buliding-blocks compound. In a article, author is Serrano-Nascimento, Caroline, introduce new discover of the category.

Excess iodide downregulates Na+/I- symporter gene transcription through activation of PI3K/Akt pathway

Transcriptional mechanisms associated with iodide-induced downregulation of NIS expression remain uncertain. Here, we further analyzed the transcriptional regulation of NIS gene expression by excess iodide using PCCl3 cells. NIS promoter activity was reduced in cells treated for 12-24 h with 10(-5) to 10(-3) M NaI. Site-directed mutagenesis of Pax8 and NF-kappa B cis-acting elements abrogated the iodide induced NIS transcription repression. Indeed, excess iodide (10(-3) M) excluded Pax8 from the nucleus, decreased p65 total expression and reduced their transcriptional activity. Importantly, p65-Pax8 physical interaction and binding to NIS upstream enhancer were reduced upon iodide treatment. PI3K/Akt pathway activation by iodide-induced ROS production is involved in the transcriptional repression of NIS expression. In conclusion, the results indicated that excess iodide transcriptionally represses NIS gene expression through the impairment of Pax8 and p65 transcriptional activity. Furthermore, the data presented herein described novel roles for PI3K/Akt signaling pathway and oxidative status in the thyroid autoregulatory phenomenon. 2016 Elsevier Ireland Ltd. All rights reserved.

Reference of 450412-29-0, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 450412-29-0 is helpful to your research.

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 619-58-9, Name is 4-Iodobenzoic acid, molecular formula is C7H5IO2, belongs to iodides-buliding-blocks compound. In a document, author is Ai, Han-Jun, introduce the new discover, Quality Control of 4-Iodobenzoic acid.

Palladium-catalyzed Heck reaction of in-situ generated benzylic iodides and styrenes

A palladium-catalyzed Heck reaction of in-situ generated benzylic iodides and styrenes has been achieved. The reaction proceeds in a one-pot manner through 1) addition perfluoroalkyl iodides to styrenes to give benzylic iodides, 2) followed by a palladium-catalyzed Heck coupling of the resulting benzylic iodides with the same alkenes in high regio- and stereoselectivity. A variety of perfluoroalkylated alkenes were obtained in moderate to excellent yields. (C) 2017 Elsevier Ltd. All rights reserved.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 619-58-9. Quality Control of 4-Iodobenzoic acid.

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Category: iodides-buliding-blocks, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 19094-56-5, Name is 2-Chloro-5-iodobenzoic acid, molecular formula is C7H4ClIO2. In an article, author is Rodriguez, AM,once mentioned of 19094-56-5.

Identification and characterization of a putative human iodide transporter located at the apical membrane of thyrocytes

Iodide transport by thyrocytes is a two step process involving transporters located either in the basal or in the apical membranes of the cell. The sodium iodide symporter (NIS) is localized in the basolateral membrane facing the bloodstream and mediates iodide accumulation into thyrocytes. Pendrin has been proposed as an apical transporter. In order to identify new iodide transporters, we developed a PCR cloning strategy based on NI sequence homologies. From a human kidney cDNA library, we characterized a gene, located on chromosome 12q23, that encodes a 610 amino acid protein sharing 46 % identity (70 % similarity) with the human NIS. Functional analysis of the protein expressed in mammalian cells indicates that it catalyzes a passive iodide transport. The protein product was immunohistochemically localized at the apical pole of the thyroid cells facing the colloid lumen. These results suggest that this new identified protein mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. It was designated hAIT for human Apical Iodide Transporter.

If you¡¯re interested in learning more about 19094-56-5. The above is the message from the blog manager. Category: iodides-buliding-blocks.

Chemistry is an experimental science, Computed Properties of C7H5IO2, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 619-58-9, Name is 4-Iodobenzoic acid, molecular formula is C7H5IO2, belongs to iodides-buliding-blocks compound. In a document, author is BHATTACHARYYA, DK.

IODIDE MODULATION OF THE EDTA-INDUCED IODINE REDUCTASE-ACTIVITY OF HORSERADISH-PEROXIDASE BY INTERACTION AT OR NEAR THE EDTA-BINDING SITE

Horseradish peroxidase (HRP) catalyses the reduction of iodinium ion (I+) to iodide by H2O2 in the presence of EDTA. I+ reduction occurs optimally at pH 6 whereas the enzyme catalyses iodide oxidation optimally at pH 3.5. Thus the two activities reside on the same enzyme with two characteristic pH optima. Iodide modulates the expression of the reductase activity by EDTA. Higher concentrations of iodide inhibit the reductase activity by EDTA. Nitrite, an electron donor, acts similarly to iodide. Both EDTA and nitrite competitively inhibit iodide oxidation, indicating that they compete with iodide for the same binding site for electron flow to the haem iron group. However, unlike iodide, EDTA converts compound I, not into the native enzyme. but into a compound absorbing at 416 nm which reduces I+ and then returns to the native form. The apparent equilibrium dissociation constant, K(D), for the formation of the EDTA-HRP complex (15 mM) is doubled in the presence of iodide, indicating interference with EDTA binding by iodide. EDTA binds away from the haem iron centre and not through intramolecular Ca2+. The pH-dependence of EDTA binding indicates that an ionizable group of the enzyme with pK(a) 5.8, presumably a distal histidine, controls the binding. The data suggest that iodide competes with EDTA for compound I and modulates the iodine reductase activity by limiting the formation of the 416 nm-absorbing active compound.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 619-58-9, in my other articles. Computed Properties of C7H5IO2.

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Quality Control of 2-Iodoacetamide144-48-9, Name is 2-Iodoacetamide, SMILES is NC(=O)CI, belongs to iodides-buliding-blocks compound. In a article, author is Bay, L, introduce new discover of the category.

Electrochemical reaction rates in a dye-sensitised solar cell-the iodide/tri-iodide redox system

The electrochemical reaction rate of the redox couple iodide/tri-iodide in acetonitrile is characterised by impedance spectroscopy. Different electrode materials relevant for the function of dye-sensitised solar cells (DSSC) are investigated. Preferably, the reaction with the iodide/tri-iodide couple should be fast at the counter electrode, i.e. this electrode must have a high catalytic activity towards the redox couple, and the same reaction must be slow on the photo electrode. The catalytic activity is investigated for platinum, poly(3,4-ethylenedioxythiophene) (PEDOT), polypyrrole (PPy), and polyaniline (PANI)-all deposited onto fluorine-doped tin oxide (FTO) glass. Both Pt and PEDOT are found to have sufficiently high catalytic activities for practical use as counter electrodes in DSSC. The reaction resistance on FTO and anatase confirmed the beneficial effect of a compact anatase layer on top of the FTO glass in lowering the tri-iodide reduction rate. (c) 2005 Elsevier B.V. All rights reserved.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 144-48-9. Quality Control of 2-Iodoacetamide.

144-48-9, Name is 2-Iodoacetamide, molecular formula is C2H4INO, Application In Synthesis of 2-Iodoacetamide, belongs to iodides-buliding-blocks compound, is a common compound. In a patnet, author is Feng, Xiujuan, once mentioned the new application about 144-48-9.

Copper-catalyzed conversion of aryl and heteroaryl bromides into the corresponding iodide

An efficient method for the synthesis of aryl and heteroaryl iodides is described in this study. The reactions of aryl and heteroaryl bromides with potassium iodide proceeded smoothly in the presence of a copper catalyst under mild reaction conditions to produce the corresponding iodides in satisfactory to excellent yields. (C) 2016 Elsevier B.V. All rights reserved.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 144-48-9. The above is the message from the blog manager. Application In Synthesis of 2-Iodoacetamide.

Electric Literature of 144-48-9, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 144-48-9, Name is 2-Iodoacetamide, SMILES is NC(=O)CI, belongs to iodides-buliding-blocks compound. In a article, author is Zhang, L, introduce new discover of the category.

Nonradioactive iodide effectively induces apoptosis in genetically modified lung cancer cells

We assessed a nonradioactive approach to induce apoptosis in non-small cell lung cancer by a novel iodide uptake and retention mechanism. To enhance tumor apoptosis, we transduced non-small cell lung cancer cells with retroviral vectors containing the sodium iodide symporter (NIS) and thyroperoxidase (TPO) genes. Expression of NIS and TPO facilitated concentration of iodide in tumors. As a consequence of the marked increase in intracellular levels of iodide, apoptosis was seen in >95% of NIS/TPO-modified lung cancer cells. Intraperitoneal injection of potassium iodide resulted in significant tumor volume reduction in NIS/TPO-modified tumor xenografts without apparent adverse effects in SCID mice. Iodide induced an increase in the level of reactive oxygen species. Iodide-induced apoptosis is sensitive to N-acetylcysteine inhibition, suggesting an important role by reactive oxygen species in this apoptotic process. In addition, iodide-induced apoptosis is associated with overexpression of CDKN1A (p21/Waf1) and down-regulation of survivin at both mRNA and protein levels. This is the first report demonstrating that a therapeutic dose of nonradioactive iodide has potent efficacy and high selectivity against lung cancer when used in combination with genetic modification of cancer cells to express the NIS/TPO genes.

Electric Literature of 144-48-9, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 144-48-9.

Synthetic Route of 619-58-9, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 619-58-9, Name is 4-Iodobenzoic acid, SMILES is O=C(O)C1=CC=C(I)C=C1, belongs to iodides-buliding-blocks compound. In a article, author is Shimada, Minami, introduce new discover of the category.

PREPARATION AND REACTION OF QUINOLINYL (OR PYRIDINYL)PHOSPHONIUM SALTS WITH BASE AND PIVALALDEHYDE

alpha- and gamma-Heteroaryltriphenylphosphonium iodides were prepared by reaction of the corresponding heteroaryl iodides with triphenylphosphine. Reaction of beta-heteroaryl iodides with triphenylphosphine in the presence of a palladium catalyst gave beta-heteroaryltriphenylphosphonium iodides. Elimination of the heteroaryl group was achieved by treating the heteroaryltriphenylphosphonium iodides with a base. Further, the heteroaryl group was trapped with pivalaldehyde to introduce a pivaloyl substituent onto the heteroaromatic ring.

Synthetic Route of 619-58-9, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 619-58-9.

Electric Literature of 3058-39-7, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 3058-39-7, Name is 4-Iodobenzonitrile, SMILES is N#CC1=CC=C(I)C=C1, belongs to iodides-buliding-blocks compound. In a article, author is Kwak, MK, introduce new discover of the category.

Anodic differential pulse voltammetric analysis of iodide with a cinchonine-modified carbon paste electrode

The stripping voltammetric determination of iodide ions has been completed using a cinchonine modified carbon paste electrode. Iodide ions were deposited onto a carbon paste electrode containing cinchonine via the ion pairing reaction in an acidic medium. The oxidation peak potential of the iodide ion is +0.65 V. The analytical conditions for the determination of the iodide ion were optimized by cyclic voltammetry. The optimal composition of CMCPE and pH of the solution on the deposition of iodide are 40% (w/w) and 2.15, respectively. Differential pulse voltammetry was applied to determine the calibration plot and detection limit. The detection limit was 8.0 x 10(-8) M for 20 min of deposition time and relative standard deviation (5 determinations) was +/- 4.2% at a 7.0 x 10(-7) M iodide solution. The interferences of anions anions and cations were investigated. The thiosulfate ion interferes with the oxidation current of the iodide ion by about 12%. Cl-, Br-, SCN-, C2O42-, ClO4-, NO3-, Co2+, Fe(CN)(6)(3-), Ni2+, Cu2+, Cd2+, Pb2+, and Hg2+ do not interfere with the determination for the iodide ion. The applicability of the CMCPE: tcs the determination of iodide in a disinfectant has also been investigated.

Electric Literature of 3058-39-7, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 3058-39-7 is helpful to your research.

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 619-58-9, Name is 4-Iodobenzoic acid, molecular formula is , belongs to iodides-buliding-blocks compound. In a document, author is Gervay, J, Name: 4-Iodobenzoic acid.

Mechanistic studies on the stereoselective formation of glycosyl iodides: First characterization of beta-D-glycosyl iodides

Treatment of glycosyl acetates with one equivalent of iodotrimethylsilane at low temperature results in the quantitative formation of glycosyl iodides. Carbohydrates that possess a participating group at the C-2 position initially form beta-D-glycosyl iodides, which quickly equilibrate to the alpha-iodo anomers. The beta anomer of peracetylated glucose reacts faster than the alpha anomer, presumably because the C-2 acetate can assist in displacing the silylated anomeric acetate. In contrast, the alpha anomer reacts faster than the beta anomer in substrates lacking a participating group at C-2. For example, activation of 1-O-acetyl-2,3,4,6-tetra-O-benzyl-alpha-D-glucopyranose leads to formation of the beta iodide, while the corresponding beta acetate produces the alpha iodide. Although the beta iodides quickly equilibrate to the alpha anomers, they can be prepared in sizable quantities at low temperatures where equilibration is slow. This report describes the first stereoselective formation and characterization of P-D-glycosyl iodides. (C) 1997 Elsevier Science Ltd.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 619-58-9, in my other articles. Name: 4-Iodobenzoic acid.