Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 33348-34-4, name is 4-Amino-3-iodobenzonitrile, A new synthetic method of this compound is introduced below., category: iodides-buliding-blocks
To a round bottomed flask equipped with an addition funnel, thermometer, reflux condenser, and nitrogen inlet were added 4-cyano-2-iodoaniline (7.88 g), acetonitrile (24 ml_), and triethylamine (4.5 ml_). Trifluoroacetic anhydride (5.0 ml.) was added to the suspension while maintaining the temperature below 35-40 0C. Note: exothermic addition is addition-rate controlled. The reaction was stirred for 30 min, diluted with water (31.5 ml_). Note: initial portion of addition is exothermic and is addition-rate controlled. The slurry was held at 15-200C for 60 min. The product was isolated by filtration. The solid was washed with 80% aqueous acetonitrile, and dried in vacuo to give the title compound as a colorless solid (9.9 g); 1H NMR (300 MHz, CDCI3) delta 8.49 (1 H, br s), 8.45 (1 H, d), 8.15 (1 H, s), 7.75 (1 H, d)
The synthetic route of 33348-34-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXO GROUP LIMITED; WO2009/127678; (2009); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com