Some common heterocyclic compound, 886762-71-6, name is 1-Fluoro-3-iodo-2-nitrobenzene, molecular formula is C6H3FINO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 1-Fluoro-3-iodo-2-nitrobenzene
K2CO3 [5.20 g, 37.7mmoi] was added to a stirred suspension of compound 3 [7.0 g, 34 mmol] in EtOH (230 mL) under ice cold condition. After addition reaction mixture was left to stir vigorously for half an hour under cold condition. Finally, compound 2 [9.16 g, 34.3 mmol] was added portion wise to the reaction mixture at 0 C, after addition reaction mixture was brought to room temperature and heated at 80 C for 40 h. After completion, EtOH were evaporated, crude was diluted with water [200 mL] and extracted with EI2O [200 L] Organic part was separated; pH of the aqueous part was slowly adjusted to 2-3 using 1 (N) aqueous HC1 under ice cooled condition and immediately extracted with EtOAc [2×200 mL] Organic part was separated, dried [MgSOr] and concentrated under reduced pressure to afford compound 4 [10.6 g, 68 4 %] as dark red floppy solid. Mass [ESI]: ra/z 451.21 j .1 – l 1.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 886762-71-6, its application will become more common.
Reference:
Patent; CYTOSITE BIOPHARMA INC.; BILCER, Geoffrey, Malcolm; KELLY, Terence, Alfred; (190 pag.)WO2019/160916; (2019); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com