The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 696-41-3, name is 3-Iodobenzaldehyde, A new synthetic method of this compound is introduced below., COA of Formula: C7H5IO
A 10 mL Schenk tube was dried in oven and loaded under N2 with K3PO4 (2.37 g,11.16 mmol) and DMA (2.0 mL). 3-iodobenzaldeide (1.85 g, 7.97 mmol) and n- butylacrylate (2.28 mL, 15.94 mmol) were then added by syringe. A solution of EPO Pd(OAc)2 (0.18 g, 0.797 mmol) in DMA (0.5 mL) was further added by syringe. The Schlenk tube was then sealed under nitrogen and placed in a pre-heated oil bath at 140 0C, and the reaction mixture was stirred for 24 h. After cooling to room temperature, the reaction mixture was poured in water (50 mL) and extracted with ethyl acetate (3 x 50 mL). The combined organic extracts were washed with brine, dried (Na2SO4), and concentrated under vacuum to dryness. The crude product was purified by chromatographic column on silica gel, eluting with n- hexane/ethylacetate/methanol 12/3/1 (yield: 47%). 1H NMR (CDCI3) delta: 0.91-0.96 (t, 3H, OCH2CH2CH2CH3), 1.39-1.42 (m, 2H, OCH2CH2CH2CH3), 1.65-1.68 (m, 2H, OCH2CH2CH2CH3), 4.17-4.21 (m, 2H, OCH2CH2CH2CH3), 6.48-6.53 (d, 1 H, ArCH=CHCO), 7.52-7.54 (m, 1 H, benzene H-5), 7.53-7.75 (m, 2H, ArCH=CHCO and benzene H-6), 7.84-7.86 (m, 1 H, benzene H-4), 7.99 (m, 1 H, benzene H-2), 10.01 (s, 1 H1 CHO).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; DAC S.R.L.; WO2006/37761; (2006); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com