In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 755027-18-0, name is 1-Bromo-4-iodo-2-methoxybenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 1-Bromo-4-iodo-2-methoxybenzene
A solution of 1-bromo-4-iodo-2-methoxybenzene (0.63 g, 2.01 mmol) dissolved in toluene (15.7 mL) was treated with 2-methoxy-N-methylethanamine (179 mg, 2.01 mmol), sodium tert-butoxide (232 mg, 2.42 mmol), Xantphos (0.116 g, 0.20 mmol) and tris(dibenzylideneacetaone)dipalladium (0) (46 mg, 0.05 mmol) under a nitrogen atmosphere. The resulting mixture was stirred at 80 C in a sealed tube for 2 hours. The reaction mixture was diluted with water (200 mL), and extracted with EtOAc (200 mL). The organic layerwas dried over MgSO4, filtered and evaporated to afford the crude product. The crudeproduct was purified by flash silica chromatography eluting with 50% Et2O in heptane. Purefractions were evaporated to dryness to afford 4-bromo-3-methoxy-N-(2-methoxyethyl)-Nmethylaniline(231 mg, 42%) as a brown solid.
The synthetic route of 755027-18-0 has been constantly updated, and we look forward to future research findings.