Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 34683-73-3, name is 1-Chloro-6-iodohexane, A new synthetic method of this compound is introduced below., HPLC of Formula: C6H12ClI
Example 6 Compound (6) is prepared as follows : Step 6. 1 : 5-(6-chlorohexyl)-2,2′-bithiophene; To a stirred solution of 2, 2′-bithiophene (10.0 g, 60.24 mmol) in anhydrous THF (150 mi) is added n-butyllithium (2.5 M in hexanes, 20.0 ml, 50.0 mmol) dropwise at-78 C under nitrogen. After complete addition, the mixture is allowed to warm to room temperature, with stirring, over 2 h, followed by the addition of 1- chloro-6-iodohexane (14.55 g, 50.0 mmol). The resultant mixture is stirred overnight at room temperature. The reaction is quenched with sat. aq. NH4Ci, and the reaction mixture is extracted with ethyl acetate (3 x 100 ml). The combined organic extracts are washed with water, brine, and dried over sodium sulphate. The solvent is removed under reduced pressure and the residue is purified by column chromatography on silica, eluting with petroleum ether, to give 5- (6- chlorohexyl)-2, 2′-bithiophene as a white solid (7.73 g, 54 %). H NMR (300 MHz, CDCl3) : 8 (ppm) 7.14 (d, J = 5.3 Hz, 1.3 Hz, 1 H, Ar-H), 7. 08 (dd, J = 3.5 Hz, 1.1 Hz, 1 H, Ar-H), 6.97 (m, 2H, Ar-H), 6.66 (d, J = 3.5 Hz, 1 H, Ar-H), 3.51 (d, J = 6.6 Hz, 2H, CICH2), 2.78 (t, J = 7.1 Hz 2H, ArCH2), 1.61-1. 81 (m, 4H, CH2), 1.35-1. 51 (m, 4H, CH2) ; MS (m/e) : 282 (M+, 2 %), 166 (8), 123 (39), 110 (22), 97 (100).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.