Month: April 2021

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 34683-73-3, name is 1-Chloro-6-iodohexane, A new synthetic method of this compound is introduced below., HPLC of Formula: C6H12ClI

Example 6 Compound (6) is prepared as follows : Step 6. 1 : 5-(6-chlorohexyl)-2,2′-bithiophene; To a stirred solution of 2, 2′-bithiophene (10.0 g, 60.24 mmol) in anhydrous THF (150 mi) is added n-butyllithium (2.5 M in hexanes, 20.0 ml, 50.0 mmol) dropwise at-78 C under nitrogen. After complete addition, the mixture is allowed to warm to room temperature, with stirring, over 2 h, followed by the addition of 1- chloro-6-iodohexane (14.55 g, 50.0 mmol). The resultant mixture is stirred overnight at room temperature. The reaction is quenched with sat. aq. NH4Ci, and the reaction mixture is extracted with ethyl acetate (3 x 100 ml). The combined organic extracts are washed with water, brine, and dried over sodium sulphate. The solvent is removed under reduced pressure and the residue is purified by column chromatography on silica, eluting with petroleum ether, to give 5- (6- chlorohexyl)-2, 2′-bithiophene as a white solid (7.73 g, 54 %). H NMR (300 MHz, CDCl3) : 8 (ppm) 7.14 (d, J = 5.3 Hz, 1.3 Hz, 1 H, Ar-H), 7. 08 (dd, J = 3.5 Hz, 1.1 Hz, 1 H, Ar-H), 6.97 (m, 2H, Ar-H), 6.66 (d, J = 3.5 Hz, 1 H, Ar-H), 3.51 (d, J = 6.6 Hz, 2H, CICH2), 2.78 (t, J = 7.1 Hz 2H, ArCH2), 1.61-1. 81 (m, 4H, CH2), 1.35-1. 51 (m, 4H, CH2) ; MS (m/e) : 282 (M+, 2 %), 166 (8), 123 (39), 110 (22), 97 (100).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 645-00-1, name is 1-Iodo-3-nitrobenzene, A new synthetic method of this compound is introduced below., Quality Control of 1-Iodo-3-nitrobenzene

General procedure: SAC (300mg) and NaBH4 (4.0mmol) were added to a solution of nitroarenes (1.0mmol) in EtOH/water (1/1) (20ml). The reaction mixture was stirred for 4h at the temperature indicated in Table3. At the end of the reaction, the catalyst was removed by filtering and the filtrate was extracted with 3×70ml EtOAc. The combined organic layers were dried over MgSO4 and concentrated in a vacuum.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Synthetic Route of 2401-21-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2401-21-0, name is 1,2-Dichloro-3-iodobenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

I. 17alpha-Chloro-17beta-Methylsulfinyl-11beta-Hydroxy-1,4-Androstadiene-3-One In a manner similar to that described in Example 2A, react 0.475 gm. 17alpha-methylthio-11beta-hydroxy-1,4-androstadiene-3-one, 12 ml. of pyridine, 3 ml. of water and 1.17 gm. of iodobenzene dichloride. Purify the residue by utilizing thin layer silica gel chromatography, developing with acetone/ethyl acetate/chloroform (6:47:47), and eluding with ethyl acetate. Crystallize from acetone/hexane to obtain the title compound; m.p. 230°-233° C. (decomp.); nmr (dmso-d6) delta 1.40 (C10 and C13 –CH3, s), 2.47 (SCH3, s), 4.28 (11alpha-H, mult.), 5.94 (C4 –H, d), 6.16 (C2 –H, dd), 7.29 (C1 –H, d).

The synthetic route of 1,2-Dichloro-3-iodobenzene has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 181765-86-6, name is Methyl 5-bromo-2-iodobenzoate, A new synthetic method of this compound is introduced below., category: iodides-buliding-blocks

2-methyl-thiophene 3.6g (17.3mmol) at -78C reacted with n-butyl lithium and triethyl borate, 5-methyl-thiophen-2-yl boronic acid to 4.42g (yield: 85%) was formed . 4.42g of 5-methyl-thiophen-2-yl boronic acid react with 5-bromo-2-iodo-benzoic acid methyl ester and 80C by the Suzuki coupling (Suzuki coupling) 7.78g of Intermediate 1 (yield: 80 %) it was synthesized. Intermediate 1 react with CH3MgCl by cyclization (cyclization) with the 3.14g (yield: 40%) intermediate 2 was synthesized . intermediate 2 was reacted with 9-phenyl-anthracene boronic acid and by Suzuki coupling compound 1 (3.3g, yield: 60%) was obtained. Compound 1 was confirmed by 1HNMR and MS.

The synthetic route of 181765-86-6 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6940-76-7, name is 1-Chloro-3-iodopropane, A new synthetic method of this compound is introduced below., Product Details of 6940-76-7

A solution of LDA in THF/heptane/ethylbenzene (2.0 M, 137 mL, 274 mmol) was added slowly over 90 min to a stirring solution of N,N’-diisopropyl-2,3-butanediimine (20.0 g, 119 mmol) in distilled THF (180 mL) under N2, maintained at -78 C and stirred for an additional 5 h. A solution of 1-chloro-3-iodopropane (57.4 g, 280 mmol) in distilled THF (20 mL) was added over 15 min and the mixture was stirred at -78 C under N2. After 15 h, aqueous HCl (1M, 600 mL) was added and the mixture was allowed to stir at room temperature (RT) for 5 h. THF was removed under reduced pressure, and CH2Cl2 (160mL x 3) was used to extract the product from the remaining aqueous layer. The organic layers were combined and washed with HCl (1M, 60mL), H2O (120 mL) and sat. NaHCO3 (120mL), and the organic layer was then dried over MgSO4. The mixture was filtered and the filtrate was concentrated under reduced pressure to yield a crude orange oil. The oil was purified by distillation (133-137 C/0.08 mmHg) to give 6 (22.5 g, 94.1 mmol, 79%) as a yellow oil. 1H NMR (500 MHz,CDCl3): 3.55 (t, J = 6.3, 4H), 2.79 (t, J = 7.1, 4H), 1.85-1.70 (m, 8H). 13C NMR (125MHz, CDCl3): 198.9, 44.4, 35.1, 31.7, 20.2. ESI-MS: m/z 241 ([M + H]+, calcd for C10H1735Cl37ClO2 , 241.17554).

The synthetic route of 6940-76-7 has been constantly updated, and we look forward to future research findings.

Electric Literature of 26670-89-3,Some common heterocyclic compound, 26670-89-3, name is 2-Bromo-4-iodo-1-methylbenzene, molecular formula is C7H6BrI, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a 1 L four-necked round bottom flask equipped with a stirrer, Erlin condenser, nitrogen inlet tube, and thermometer, 19.3 g (91.0 mmol) of 4-dibenzofuran boronic acid of Synthesis Example 8, 2 (100.0 mmol) of bromo-4-iodotoluene, 300 mL of toluene, 150 mL of ethanol, 25.1 g (181.5 mmol) of potassium carbonate and 90 mL of water, and the mixture was stirred at room temperature for 30 minutes under a nitrogen stream. Subsequently, 0.10 g (0.45 mmol) of palladium acetate and 0.27 g (0.91 mmol) of tri (o-tolyl) phosphine were added and heated, followed by stirring at a reflux temperature for 2 hours. The resulting reaction solution was cooled to room temperature, the aqueous layer was separated, and extracted twice with 100 mL of ethyl acetate. Next, the organic layers were combined, washed with 100 mL of saturated brine, dried over magnesium sulfate, magnesium sulfate was removed by suction filtration, and the solvent was distilled off under reduced pressure. Subsequently, the obtained oily matter was separated by silica gel column chromatography with a mixed solvent of n-heptane and toluene to obtain 23.3 g (yield: 75.9%) of the desired bromide.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Bromo-4-iodo-1-methylbenzene, its application will become more common.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 755027-18-0, name is 1-Bromo-4-iodo-2-methoxybenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 1-Bromo-4-iodo-2-methoxybenzene

A solution of 1-bromo-4-iodo-2-methoxybenzene (0.63 g, 2.01 mmol) dissolved in toluene (15.7 mL) was treated with 2-methoxy-N-methylethanamine (179 mg, 2.01 mmol), sodium tert-butoxide (232 mg, 2.42 mmol), Xantphos (0.116 g, 0.20 mmol) and tris(dibenzylideneacetaone)dipalladium (0) (46 mg, 0.05 mmol) under a nitrogen atmosphere. The resulting mixture was stirred at 80 C in a sealed tube for 2 hours. The reaction mixture was diluted with water (200 mL), and extracted with EtOAc (200 mL). The organic layerwas dried over MgSO4, filtered and evaporated to afford the crude product. The crudeproduct was purified by flash silica chromatography eluting with 50% Et2O in heptane. Purefractions were evaporated to dryness to afford 4-bromo-3-methoxy-N-(2-methoxyethyl)-Nmethylaniline(231 mg, 42%) as a brown solid.

The synthetic route of 755027-18-0 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4387-36-4, name is 2-Iodobenzonitrile, A new synthetic method of this compound is introduced below., Product Details of 4387-36-4

Weigh 0.02 mM halogenated aromatic hydrocarbon in a reaction flask, add 1 mL of solvent, and fill the reaction flask with nitrogen.Deoxygenation was performed for 10 minutes and 15 yL of triethylamine was added during the deoxygenation.After that, the reaction vessel was sealed, placed over a light-emitting diode (LED) with a wavelength of 400 nm and a power of 0.5 W, and the reaction was stirred at room temperature for 12 hours.After that, the dehalogenation reaction yield was characterized by gas chromatography-mass spectrometry.The yield of o-phenylacetonitrile was 80.7percent, and the characterization results of the gas chromatography and mass spectrometry were shown in Figure 2. The halogenated aromatic hydrocarbon waso-Iodobenzeneacetonitrile, the solvent is tetrahydrofuran.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 98-61-3, name is 4-Iodobenzenesulfonyl chloride, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 98-61-3

(R) – [3- [3- (3-fluoro-4-morpholinophenyl) -2-oxo-5-oxazolidinyl] methyl alcohol (3.9 g, 13.16 mmol) ,CH2Cl2, triethylamine (3.67 mL, 26.13 mmol).A solution of p-iodobenzenesulfonyl chloride (15.8 mmol) in CH2Cl2 was added dropwise,Reaction at room temperature for 18 hours.TLC monitoring, the reaction is completed, the reaction solution water washing, saturated NaCl solution washing,Dried over anhydrous Na2SO4, filtered, dried to give the crude product,Recrystallization gave the product (R) -N- [3- (3-fluoro-4-morpholinophenyl) -2-oxo-5-oxazolidinyl] methyl p-iodobenzenesulfonic acidEster 6.1 g,Yield: 82.5%, chemical purity: 98.9%

According to the analysis of related databases, 98-61-3, the application of this compound in the production field has become more and more popular.

Adding a certain compound to certain chemical reactions, such as: 54435-09-5, name is 2-Iodo-4-methoxybenzoic acid, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 54435-09-5, Application In Synthesis of 2-Iodo-4-methoxybenzoic acid

(c) K2 CO3 (13.94 g, 0.101 mol) was dissolved in water (67 ml) and then 2-iodo-4-methoxybenzoic acid (25.3 g, 0. 091 mol) was added, followed by 5-amino-1-ethylpyrazole (11.2 g, 0.101 mol) and finally copper (2.7 g). The reaction mixture was refluxed for 20 hours, cooled to room temperature and then water (350 ml) was added and the mixture was refluxed for 0.75 hours. The reaction mixture was cooled, and the product was collected by filtration, recrystallized from ethanol, and dried in an oven at 40 C. to afford 13.37 g (56%) of N-(1-ethylpyrazol-5-yl) -4-methoxyanthranilic acid, m.p. 130-135 C.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Iodo-4-methoxybenzoic acid, other downstream synthetic routes, hurry up and to see.