Extracurricular laboratory: Synthetic route of 1,5-Diiodopentane

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 628-77-3.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 628-77-3, name is 1,5-Diiodopentane, This compound has unique chemical properties. The synthetic route is as follows., Safety of 1,5-Diiodopentane

Example 19. (1 laS, 1 ia?S)-8,8-(pentane- 1 ,5-diylbis(oxy))bis(7-methoxy-2-methylene-23-dihydro- 1H-benzo[e]pyrrolo[ 1 ,2-aj [1 ,4jdiazepin-5( 11 aH)-one) (97) To a stirred suspended solution of Cs2CO3 (0.761 g, 2.33 mmol) in butanone (8 ml) were added (S)-8-hydroxy-7-methoxy-2-methyiene-2,3-dihydro- 1 H-benzo[e]pyrroio[ 1,2- aj[1,4jdiazepin-5(1 laH)-one (401 mg, 1.55 mmol) and 1,5-diiodopentane (240 mg, 0.740mmol). The mixture was stirred at RT overnight, concentrated, and purified on Si02 chromatography eluted with EtOAc/CH2C12 (1:10) to afford 337 rng (78% yield) of the title producL ElMS mlz 607.2 ([Mj+Na).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 628-77-3.