Month: May 2021

Some common heterocyclic compound, 90347-66-3, name is Methyl 3-iodo-4-methylbenzoate, molecular formula is C9H9IO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of Methyl 3-iodo-4-methylbenzoate

A mixture of 19 (1366 mg, 4.63 mmol), (S)-tert-butyl piperidin-3-ylcarbamate (1020mg, 4.63 mmol) and K2CO3 (768 mg, 5.56 mmol) in DMF (8 mL) was stirred at roomtemperature overnight. Water was added and the mixture was extracted with EtOAc twice. Thecombined organic layers were washed with brine, dried over Na2SO4 and concentrated. Theresidue was purified by silica gel column chromatography to give 34 (870 mg, 45%) as aslightly yellow solid. LCMS (m/z: m+1): 414.0, 116.1. A suspension of 34 (870 mg, 2.1 mmol),1 (517 mg, 6.3 mmol), K2CO3 (580 mg, 4.2 mmol), CuI (120 mg, 0.63 mmol) and 8-hydroxyquinoline (61 mg, 0.42 mmol) in DMSO (8 mL) was heated at 120C overnight undernitrogen. After cooling, water was added and the mixture was extracted with EtOAc twice. Thecombined organic layers were washed with brine, dried over Na2SO4 and concentrated. Theresidue was purified by silica gel column chromatography to give 35 (630 mg, 72%) as aslightly yellow solid. LCMS (m/z: m+1): 416.3. A mixture of 35 (630 mg, 1.52 mmol) andSnCl2 2H2O (1369 mg, 6.06 mmol) in EtOH (13 ml) was heated at 80C for 1 h. After cooling,silica gel was added to the reaction and the mixture was concentrated to dryness. The residuewas purified by silica gel column chromatography to give 36 (430 mg, 74%) as a slightlyyellow solid. LCMS (m/z: m+1): 386.4. A mixture of 37 (9.5 g, 73.3 mmol), 4-fluorophenylboronic acid (10.3 g, 73.3 mmol), Na2CO3 (15.5 g, 147 mmol), and Pd(PPh3)4 (1.5g) in CH3CN/H2O (2/1, 200 mL) was heated at reflux under N2 for 16 h. After cooling, themixture was diluted with water and extracted with EtOAc twice. The combined organic layerswere washed with brine, dried over Na2SO4, filtered, concentrated and purified by silica gelcolumn chromatography to give 38 (5.1 g, 37%) as a slightly yellow solid. LCMS (m/z: m+1):190.2. A mixture of 38 (5.1 g, 27.0 mmol), 39 (11.2 g, 40.4 mmol), K2CO3 (7.5 g, 54.0 mmol),DMEDA (476 mg, 5.4 mmol) and CuI (1.28 g, 6.7 mmol) in 100 mL of dioxane was stirred at100C under N2 for 24 h. The mixture was filtered, concentrated and purified by columnchromatography to give 40 (1.6 g, 18%) as a slightly yellow solid. LCMS (m/z: m+1): 338.3.To a solution of 40 (1.6 g, 4.74 mmol) in THF/H2O (32/16 mL) was added LiOH (341 mg,14.2 mmol). The reaction was stirred at room temperature overnight and then concentrated. Tothe residue, water was added and then acidified to pH 4 with aqueous KHSO4. The precipitatewas filtered and washed with water and EtOAc. The cake was collected and dried to give 41(1.3 g, 85%) as an off-white solid. LCMS (m/z: m+1): 324.1. A mixture of 36 (130 mg, 0.34mmol), 41 (109 mg, 0.34 mmol), HATU (257 mg, 0.68 mmol) and DIEA (218 mg, 1.69 mmol)in DMF (2 mL) was heated at 70C overnight. After cooling, the reaction mixture was directlypurified by reverse prep-HPLC and then silica gel prep-TLC to give 42 (33 mg, 14%) as aslightly yellow solid. LCMS (m/z: m+1): 691.3. To a solution of 42 (33 mg, 0.048 mmol) inCH2Cl2 (2 mL) was added TFA (1 mL) and the reaction was stirred at room temperature for 4h before being concentrated under reduced pressure. The residue was treated with water,basified with 0.5 N NaOH and extracted with CH2Cl2/MeOH (15/1) 3 times. The combinedorganic layers were dried over Na2SO4, filtered, concentrated and purified by reverse prep-HPLC to give 2a (14 mg, 50%) as an off-white solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 90347-66-3, its application will become more common.

Reference:
Article; Bonnar, James; Dixon, Ian; Evison, Benny J.; Kelly, Graham E.; Kumar, Sanjay; Lambert, Gilles; Nativel, Brice; Palmer, James T.; Parmar, Jasneet; Rathi, Anuj Kumar; Suchowerska, Alexandra K.; Tang, Wei; Teng, Yanfen; Treutlein, Herbert; Wang, Jie; Xu, Yanfeng; Zeng, Jun; Zhu, Qing; Chemello, Kevin; Bioorganic and medicinal chemistry; vol. 28; 6; (2020);,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 672293-33-3, name is Methyl 4-amino-5-iodo-2-methylbenzoate, A new synthetic method of this compound is introduced below., Quality Control of Methyl 4-amino-5-iodo-2-methylbenzoate

To a solution of methyl 4-amino-5-iodo-2-methylbenzoate 2 (0.84 g, 2.90 mmol, 1 eq.) in DMF (10 mL), 2-oxobutyric acid (1.48 g, 14.5 mmol, 5 eq.) and DABCO (0.975 g, 8.7 mmol, 3 eq.) were added. The solution was stirred for 5 min and then palladium (II) diacetate (0.03 g, 0.145 mmol, 0.05 eq.) was added. The mixture was warmed to 105C, stirred during 16 h and then concentrated. The resulting solid was dissolved in AcOEt (150 mL) and washed with water (150 mL). The organic layer was dried over anhydrous Na2SO4 and concentrated in vacuuo to obtain dark brown solid which was purified by trituration in AcOEt to give the desired indole 6 as grey powder (358 mg, 1.45 mmol, 50%); Mp : 280-282C (Dec.); Rf = 0.61 (SiO2, Cyc/AcOEt, 5/5); 1H NMR (400 MHz, CD3OD) 8.30 (s, 1H, H-4), 7.25 (s, 1H, H-7), 3.99 (s, 3H, CH3), 2.65 (s, 3H, CH3), 2.59 (s, 3H, CH3); 13C NMR (100 MHz, CD3OD) 168.1 (C=O), 165.3 (C=O), 139.6 (C), 137.2 (C), 128.0 (C), 127.7 (C), 125.6 (CH), 122.3 (C), 118.9 (C), 114.8 (CH), 52.1 (CH3), 22.9 (CH3), 9.94 (CH3); HR-ESIMS: [M-H]- m/z calcd for C13H12NO4 246.0766 found 246.0777.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Vogrig, Alexandre; Boucherle, Benjamin; Deokar, Hemantkumar; Thomas, Isabelle; Ripoche, Isabelle; Lian, Lu-Yun; Ducki, Sylvie; Bioorganic and Medicinal Chemistry Letters; vol. 21; 11; (2011); p. 3349 – 3353;,
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These common heterocyclic compound, 51839-15-7, name is Dimethyl 5-iodoisophthalate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of Dimethyl 5-iodoisophthalate

Step A and B: Cross-coupling and Saponification. To a solution of dimethyl 5-iodoisophthalate (13 g, 40.6 mmol) in 100 mL THF was added 2-cyano-phenyl zinc bromide (97.5 mL, 48.7 mmol, 0.5 M THF) and tetrakis(triphenylphosphine) palladium (214 mg, 0.2 mmol) and the reaction mixture was stirred at room temperature for 2 h. The precipitated solid was filtered, the filtrate was diluted with MeOH to provide after filtration a second crop for a total of 10.1 g of dimethyl 5-(2-cyanophenyl)isophthalate which was hydrolyzed to the corresponding monoacid 2′-cyano-5-(methoxycarbonyl)-1,1′-biphenyl-3-carboxylic acid following a similar procedure as described in intermediate B preparation, step C: 1H NMR (400 MHz, d6-DMSO) delta 13.55 (br s, 1H), 8.60-8.55 (m, 1H), 8.38-8.31 (m, 2H), 8.02 (d, J=8.3 Hz, 1H), 7.85 (td, J=8.3 Hz, 1.5 Hz 1H), 7.75 (d, J=8.3 Hz, 1H), 7.66 (td, J=8.3 Hz, 1.5 Hz 1H), 3.93 (s, 3H).

The synthetic route of Dimethyl 5-iodoisophthalate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Barrow, James C.; Coburn, Craig A.; Nantermet, Philippe G.; Selnick, Harold G.; Stachel, Shawn J.; Stanton, Matthew G.; Stauffer, Shaun R.; Zhuang, Linghang; Davis, Jennifer R.; US2007/142634; (2007); A1;,
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Synthetic Route of 6213-88-3,Some common heterocyclic compound, 6213-88-3, name is (E)-Methyl 3-iodoacrylate, molecular formula is C4H5IO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Method 1: To a dry Schlenk flask was added Pd(OAc)2 (36 mg,0.16 mmol), P(o-tol)3 (0.10 g, 0.33 mmol) and AgOAc (0.601 g,3.60 mmol). The flask was purged with argon, and dry, degassed MeCN (10 mL) was added. 4,4,6-Trimethyl-2-vinyl-1,3,2-dioxaborinane (0.655 mL, 3.80 mmol) was then added, followed by methyl (2E)-3-iodoprop-2-enoate (0.704 g, 3.32 mmol). The vessel was purged further with argon, and the reaction mixture was then heated to 50 C with vigorous stirring for 2 days. The mixture was allowed to cool, then diluted with Et2O (280 mL) and passed through a short Celite/silica plug. The organic extracts were washed with 5% HCl (40 mL), H2O (80 mL) and brine (80 mL), dried over MgSO4, filtered and evaporated to yield 0.98 g of crude product as an orange oil. The crude product was purified by silica gel chromatography, eluent 10% EtOAc in hexane elution. Pure fractions were evaporated to yield (2E,4E)-5-(4,4,6-trimethyl-[1,3,2-dioxaborinan-2-yl]-penta-2,4-dienoic acid methyl ester as a yellow oil (0.404 g, 51%). 1H NMR (400 MHz, CDCl3): delta 1.35-1.24 (9H, m), 1.5-1.47 (1H, m), 1.81 (1H, dd, J = 14.0, 2.9 Hz), 3.75 (3H, s), 4.24 (1H, dqd, J = 12.3, 6.2, 2.9 Hz), 5.99-5.86 (2H, m), 6.97 (1H, ddd, J = 17.3, 11.0, 0.7 Hz), 7.33-7.21 (1H, m); 11B NMR (128 MHz, CDCl3): delta 25.52; 13C NMR (101 MHz, CDCl3): delta 23.58, 28.62, 31.65, 46.41,52.12, 65.52, 71.67, 123.17, 143.89, 146.54, 167.93; IR (upsilonmax, cm-1) 2974.3 (w) 1719.5 (s) inter alia; LCMS (ESI) 239.2; HRMS (ESI) calculated [C12H19BO4H] 238.1470, found 238.1491. Method 2: To a dry flask was added methyl (2E)-3-iodoprop-2-enoate (2.82 g, 13.3 mmol), Pd(OAc)2 (0.150 g, 0.67 mmol), P(otol)3 (0.408 g, 1.34 mmol) and AgOAc (2.41 g, 14.4 mmol). The flask was purged with argon, and dry, degassed MeCN (80 mL) wasadded. 4,4,6-Trimethyl-2-vinyl-1,3,2-dioxaborinane (2.6 mL,15 mmol) was then added, the vessel was purged further with argon, and the reaction mixture was then heated to 50 C with vigorous stirring for 23h. The mixture was allowed to cool, then diluted with Et2O (200 mL) and passed through a short Celite/silicaplug. The organic extracts were washed with NH4Cl (200 mL), H2O(200 mL) and brine (200 mL), dried over MgSO4, filtered and evaporated to give crude product as a yellow oil (2.65 g, 83%). The compound was taken on to the next stage without any further purification or characterisation. Method 3: To a dry flask was added methyl (2E)- 3-iodoprop-2-enoate (2.82 g, 13.3 mmol), Pd(OAc)2 (0.15 g, 0.67 mmol), P(o-tol)3(0.408 g, 1.34 mmol) and AgOAc (2.41 g, 14.4 mmol). The flask was purged with argon, and dry, degassed MeCN (72 mL) was added. 4,4,6-Trimethyl-2-vinyl-1,3,2-dioxaborinane (2.6 mL, 15 mmol) was then added, the vessel was purged further with argon, and the reaction mixture was then heated to 30 C with vigorous stirring for 19 h. The mixture was allowed to cool, then diluted with Et2O (200 mL) and passed through a short Celite/silica plug. The solvent was evaporated to give crude product as a yellow oil (2.84 g, 89%).The compound was taken on to the next stage without any further purification or characterisation. Method 4: To a dry flask was added methyl (2E)-3-iodoprop-2-enoate (1.0 g, 4.7 mmol), Pd(OAc)2 (0.011 g, 0.047 mmol), tri(2-furyl)phosphine (0.022 g, 0.094 mmol) and AgOAc (0.851 g, 5.11 mmol). The flask was purged with argon, and dry, degassed MeCN (28 mL) was added. 4,4,6-Trimethyl-2-vinyl-1,3,2-dioxaborinane (0.93 mL, 5.4 mmol) was then added, the vessel was purged further with argon, and the reaction mixture was stirred vigorously at room temperature for 3 days. The mixture was diluted with Et2O (71 mL) and passed through a short Celite/silica plug. The solvent was evaporated to give crude product as a pale yellow oil (1.18 g, 99%). The compound was taken on to the next stage without any further purification or characterisation.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (E)-Methyl 3-iodoacrylate, its application will become more common.

Reference:
Article; Madden, Katrina S.; Knowles, Jonathan P.; Whiting, Andrew; Tetrahedron; vol. 75; 45; (2019);,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 112671-42-8, name is 4-Bromo-1-iodo-2-nitrobenzene, This compound has unique chemical properties. The synthetic route is as follows., Safety of 4-Bromo-1-iodo-2-nitrobenzene

Intermediate M2-b (4.8 g, 15 mmol), 2-iodo-5-bromonitrobenzene (5.9 g, 18 mmol),Sodium tert-butoxide (2.9 g, 30 mmol), 50 mL of toluene, protected with nitrogen,0.17 g of d2(dba)3, tri-tert-butylphosphine (11 ml, 10% in toluene),The stirring was started, and the mixture was heated to reflux at 100 C for 12 hours.The reaction solution is washed with water, and the organic phase is concentrated and passed through a silica gel column.The eluent is petroleum ether: ethyl acetate = 50:1, concentrated eluent,Obtaining intermediate M2-c(6.6 g, yield 84.6%).

According to the analysis of related databases, 112671-42-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Beijing Dingcai Technology Co., Ltd.; Gu’an Dingcai Technology Co., Ltd.; Fan Hongtao; Zhang Yaguang; Zhang Xianghui; Ren Xueyan; (39 pag.)CN108341824; (2018); A;,
Iodide – Wikipedia,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1219741-79-3, name is 4-Bromo-5-fluoro-2-iodoaniline belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 4-Bromo-5-fluoro-2-iodoaniline

To a vial was added, 4-bromo-5-fluoro-2-iodoaniline (5.67 g, 17.95 mmol), PdOAc2 (0.201 g, 0.897 mmol), sodium bicarbonate (3.77 g, 44.9 mmol), ethyl acrylate (2.049 ml, 18.85 mmol) and DMF (12.0 ml). The reaction was heated for 3 hour at 100 C. The reaction was cooled to RT, diluted with water and extracted with DCM (3*). The combined organics were washed with water and brine, dried over magnesium sulfate, filtered and concentrated. The resulting material was triturated with heptane overnight and then filtered to afford (E)-ethyl 3-(2-amino-5-bromo-4-fluorophenyl)acrylate (4.00 g, 13.88 mmol, 77% yield) as a light yellow solid. m/z (ESI) 288.0 (M+H)+.

The synthetic route of 1219741-79-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Amgen Inc.; Weiss, Matthew; Boezio, Alessandro; Boezio, Christiane; Butler, John R.; Chu-Moyer, Margaret Yuhua; Dimauro, Erin F.; Dineen, Thomas; Graceffa, Russell; Guzman-Perez, Angel; Huang, Hongbing; Kreiman, Charles; La, Daniel; Marx, Isaac E.; Milgrim, Benjamin Charles; Nguyen, Hanh Nho; Peterson, Emily; Romero, Karina; Sparling, Brian; US9212182; (2015); B2;,
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Reference of 52807-27-9,Some common heterocyclic compound, 52807-27-9, name is 4-Chloro-2-iodoanisole, molecular formula is C7H6ClIO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

4-Chloro-2-iodophenol; 109.4g (0.436mol) of boron tribromide were added over 10 minutes to a stirred solution of 9Og (0.335mol) of 4-chloro-2-iodoanisole in dichloromethane (900ml) at -780C under nitrogen. Cooling was removed and allowed to warm to room temperature and stirred for 5 hours. Poured onto ice and diluted with a further 800ml of water. The organic phase was separated, the aqueous extracted with dichloromethane and the combined organics washed with saturated sodium bicarbonate, dried and evaporated to give 84.87g of off- white solid; Sodium 6-r(5-chloro-2-fr(4-chloro-2-fluorophenyl)methvnoxy)phenyl)methvn-2- pyridinecarboxylate (Alternative route 2); 4-Chloro-2-iodophenol; Boron tribromide (1349g) was added to a solution of 4-chloro-2-iodoanisole (1025g) in dichloromethane (10.3L) under nitrogen at such a rate that the temperature remained at 0- 5C The solution was then warmed to 200C and stirred for c. 19h until the reaction was complete by HPLC. This organic solution was added to water (8.2L) and the mixture was cooled to 5C to 10C. DCM (770ml) was added and the resuting biphasic mixture was then stirred at 50C for 15 min before being warmed to 220C and then finally stirred at 22C for 20 min before separating the phases. The separated organic phase was washed with aqueous saturated sodium bicarbonate (3.1L), water (3.1L) and then evaporated on a Buchi to give the title compound. (963.6g)

The synthetic route of 52807-27-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GLAXO GROUP LIMITED; WO2006/66968; (2006); A1;,
Iodide – Wikipedia,
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Adding a certain compound to certain chemical reactions, such as: 7681-82-5, name is Sodium iodide, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7681-82-5, Recommanded Product: 7681-82-5

NaI (73 mg, 0.487 mmol) in CH2Cl2 (5 ml) was added to[Ni(Cl2(Lbenz)] 3a (90 mg, 121 mmol) in CH2Cl2 (10 ml). The mixturewas stirred 24 h, was filtered over Celite and was concentrated by volume to afford 100mg (90%) of 3c as a red solid that was isolatedby filtration. 1H NMR (CDCl3): d 7.62 (d, J 7.2, ortho, 4H, -C6H5),7.40 (t, J 7.6, meta, 4H, -C6H5), 7.31 (t, J 7.6, para, 2H, -C6H5),7.19e7.22 (m, 4H, benzimi -CH]CH), 7.13e7.15 (m, 4H, benzimi),5.29 (bs, 8H, -benzimi-NCH2), 3.75 (s, 4H, -NCH2Ph), 3.11 (bs, 8H,PhCH2CH2CH2), 2.59 (t, J 5.6, 8H, CH2NCH2Ph). 13C NMR (CD2Cl2):d 190.4, 141, 136, 129.5, 128.8, 127, 122, 109.6, 60, 54, 46, 30, 28. 13CNMR (CDCl3): d 190, 140, 136, 129, 128.7, 127, 122, 109, 59.5, 53, 46,27. HR FT-ICR MS: found 462.0680 (calcd for C40H46I2N6NiH, m/z[3c H]2 462.0686).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Thapa, Rajesh; Kilyanek, Stefan M.; Journal of Organometallic Chemistry; vol. 901; (2019);,
Iodide – Wikipedia,
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Electric Literature of 105202-02-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 105202-02-6, name is 2-Iodo-5-(trifluoromethyl)aniline, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: PdCl2(PPh3)2 (35.1 mg, 0.05 mmol), CuI (9.5 mg, 0.05 mmol), PPh3 (13.1 mg, 0.05 mmol) and iodoaniline derivatives (1.00 mmol) were stirred under N2 in a mixed solvent with CH3CN (5 mL) and Et3N (1 mL). The alkyne (1.20 mmol) was added to the mixture and stirred in reflux. The reaction was monitored by TLC. After completion, H2O (10 mL) was added to the reaction mixture and extracted with ethyl acetate (3 × 10 mL). The combined organic solution was washed with brine, dried over anhydrous MgSO4, concentrated at the reduced pressure. And the crude product was purified by column chromatography to give 2-alkynylanilines.

The chemical industry reduces the impact on the environment during synthesis 2-Iodo-5-(trifluoromethyl)aniline. I believe this compound will play a more active role in future production and life.

Reference:
Article; Zhang, Sheng-Yan; Sun, Shan-Gang; Guo, Yu-Shuang; Lu, Xiao-Fan; Guo, Dian-Shun; Tetrahedron Letters; vol. 59; 41; (2018); p. 3719 – 3723;,
Iodide – Wikipedia,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 35453-19-1, name is 5-Amino-2,4,6-triiodoisophthalic acid belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C8H4I3NO4

Synthesis of 5-Amino-2,4,6-triiodo-isophthaloyl dichloride (1)5-Amino-2,4,6-triiodo-isophthalic acid (30 g, 0.054 mol) (commercially available from Aldrich), thionyl chloride (8.2 ml, 0.113 mol) and pyridine (0.2 ml) in 1 ,2 dichloroethane (20 ml) were heated to 70 0C. A portion of thionyl chloride (15.2 ml, 0.21 mol) was added dropwise during VA to 2 hrs, and the mixture was heated to 85 0C for 6 hrs. After cooling the reaction mixture to room temperature, it was poured into 30Og of ice-water. The yellow precipitate that formed was filtered off, air dried and then washed with water until washings showed a pH of ca 5. The filter cake was then dried in a vacuum oven at 500C for 3 hrs. A light yellow powder was obtained 31 g (~ quant.) as the desired product.13C NMR (DMSOd6) 66, 78.4, 148.9, 149.2, 169MS (ES-) found 593.5 [M-H+], expected 593.7

The synthetic route of 35453-19-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GE HEALTHCARE AS; WO2009/5364; (2009); A1;,
Iodide – Wikipedia,
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