Month: June 2021

These common heterocyclic compound, 31827-94-8, name is 2-Bromo-1-(4-iodophenyl)ethanone, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C8H6BrIO

General procedure: All 1-substituted 2-hydroxy-2-aryl-2,3-dihydro-imidazo[1,2-a]pyrimidinium salts were synthesized by using previously described protocols.41 A general procedure is described below (with compound 79 as an example): In a 30 mL microwave vial were successively brought acetonitrile (15 mL), N-(1,3-benzodioxol-5-ylmethyl)pyrimidin-2-amine (1.15 g, 5 mmol), 4-fluorophenacylbromide (1.3 g, 6 mmol, 1.2 equiv), and a catalytic amount of4-dimethylaminopyridine (6 mg, 0.05 mmol). The reaction tube was sealed and irradiated in a microwave reactor at a ceiling temperature of 80 C at 150 W maximum power for 30 min. After the reaction mixture was cooled with an air flow for 15 min, the precipitate was washed with acetone (25 mL), ether (20 mL) and dried in vacuum to afford 79 (1.98 g, 89% yield) as a white powder.

The synthetic route of 2-Bromo-1-(4-iodophenyl)ethanone has been constantly updated, and we look forward to future research findings.

Reference:
Article; Steenackers, Hans P.L.; Ermolat’Ev, Denis S.; Savaliya, Bharat; Weerdt, Ami De; Coster, David De; Shah, Anamik; Van Der Eycken, Erik V.; De Vos, Dirk E.; Vanderleyden, Jozef; De Keersmaecker, Sigrid C.J.; Bioorganic and Medicinal Chemistry; vol. 19; 11; (2011); p. 3462 – 3473;,
Iodide – Wikipedia,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 19718-49-1, name is Methyl 4-amino-3-iodobenzoate, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 19718-49-1

A combined suspension of methyl 4-amino-3-iodobenzoate (2,72 g, 9.83 mmol), copper (_) iodide (37 mg, 0.20 mmol), bis(triphenylphosphine)palladium(II) dichloride (138 mg, 0.20 mmol), and tert-butyl((4-ethynylbenzyl)oxy)dimethylsilane (2.91 g, 11.79 mmol) were stirred in toluene and TEA (1/1, 82 mL) at ambient temperature for overnight. The reaction solvent was evaporated under reduced pressure, and the residue was purified by column chromatography with hexane/ethyl acetate (7/1, v/v) to obtain the compound 62 as a brown solid (3.89 g, quant. yield):

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 19718-49-1.

Reference:
Patent; BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM; DALBY, Kevin N.; EDUPUGANTI, Ramakrishna; TALIAFERRO, Juliana; LEE, Juhyeon; (0 pag.)WO2018/160967; (2018); A1;,
Iodide – Wikipedia,
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Related Products of 6940-76-7, These common heterocyclic compound, 6940-76-7, name is 1-Chloro-3-iodopropane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of ethyl 3-oxobutanoate (1.95 g, 14.98 mmol) in tetrahydrofuran (20 mL) was added dropwise to a stiired 1 M solution of lithium diisopropylamine (30 mL, 30 mmol) at-78 C. The solution was stirred for an additional hour at-78 C, and then a solution of 1-chloro-3-iodopropane (3.07 g, 15.02 mmol) in tetrahydrofuran (50 mL) was added. The resulting solution was allowed to warm to room temperature and stirred for an additional two hours. Water was added, and the mixture was extracted twice with ethyl acetate. The combined organic layers were dried (Na2SO4) and concentrated. The resulting residue was purified via MPLC eluting with a gradient of 20-50% ethyl acetate in petroleum ether to afford ethyl 7-chloro-3-oxoheptanoate (2.8 g, 90%) as an oil.

The synthetic route of 6940-76-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LYCERA CORPORATION; AICHER, Thomas, Daniel; TAYLOR, Clarke, B.; VANHUIS, Chad, A.; WO2015/171610; (2015); A2;,
Iodide – Wikipedia,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 148836-41-3, name is 1-Bromo-4-chloro-2-iodobenzene, A new synthetic method of this compound is introduced below., Product Details of 148836-41-3

Step B: Preparation of l -Bromo-4-chloro-2-(3,3,3-triethoxyprop- l -ynyl)benzene; [08941 lambda mixture of l -bromo-4-chloro-2-iodoben/cne ( 1 0 g. 32 mmol) in 100 mL degassed ACN and TEA (29 g. 284 mmol), was treated with 3.3,3- triethoyprop- l -ync (6.0 g, 35 mmol), copper(l) iodide (0.60 g. 3.2 mmol), and dichltheta.Obis(triphenylphosphine)palladium(H) ( 1. 1 g, 1 .6 mmol). The mixture was stirred at room temperature for 2 hours at room temperature (the mixture turned dark green after 5 minutes). TLC showed that all starting material was converted, and a new spot was produced. The mixture was concentrated in vacuo. The residue was diluted with 100 ml. ether, washed with H2O (2 20 mL), 5% ammonia water (2 x 20 ml.), brine (20 ml.), dried over anhydrous Na2SO4, and concentrated in vacuo. The crude product was purified by column chromatography pretreated with TEA and eluted with 0-15 % EtOAc/hexane to give 7.6 g of the product as a pale yellow oil. The oil solidified after it was stored in the refrigerator.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; AMGEN INC.; WO2008/76427; (2008); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of 20555-91-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 20555-91-3, name is 1,2-Dichloro-4-iodobenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: A mixture of 8-aminoquinoline (0.4mmol), an appropriate carbonyl chloride (0.4mmol), an appropriate aryl iodide (0.16-0.24mmol, 4-6 equiv), Pd(OAc)2 (10mol %) and Ag2CO3 (0.6-0.8mmol, 1.5-2 equiv) was heated in o-xylene (2mL) at 110 C for an appropriate reaction period (12-36 h). Then, reaction mixture was cooled to rt and the solvent evaporated in vacuo to give the crude product, which was purified by chromatography to give the corresponding C-H arylated products (see the respective Tables 1-4/Scheme 2 for the specific entries and reaction conditions).

The synthetic route of 1,2-Dichloro-4-iodobenzene has been constantly updated, and we look forward to future research findings.

Reference:
Article; Mohan, Sruthi; Gopalakrishnan, Bojan; Babu, Srinivasarao Arulananda; Tetrahedron; vol. 72; 39; (2016); p. 5853 – 5863;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 77317-55-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 77317-55-6, name is Methyl 2-amino-5-iodobenzoate belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A mixture of CuI (110 mg, 0.58 mmol), Pd(OAc)2 (60 mg, 0.27 mmol), and Ph3P (130 mg, 0.49 mmol) in MeCN (30 mL) deaerated (UST) under argon atmosphere was stirred at 20 C for 20 min. Iodide 6 (1.39 g, 5.0 mmol), Et3N (1.53 g, 15.11 mmol, 2.1 mL), H2O (0.15 g, 8.33 mmol), and finely ground CaC2 (1.0 g, 15.60 mmol) were then added. The reaction mixture was stirred for 7 h and concentrated in vacuo; the residue was extracted with hot EtOAc. The extract was filtered and concentrated in vacuo, the residue was purified by chromatography on SiO2 using gradient elution of PhH -> PhH/EtOAc (4 : 1). Diarylalkyne 2a (0.57 g, 70%) was isolated as yellow crystals, m.p. 245-249 C. HRMS (ESI), found m/z: 325.1179, 347.0997; C18H16N2O4; calculated 325.1183 [M + H]+, 347.1002 [M + Na]+. IR (KBr), nu/cm-1:788, 834, 985, 1103, 1162, 1235, 1300, 1430, 1506-1663, 1688, 2342, 2361, 2838-3033, 3367, 3464. 1H NMR (DMSO-d6), delta: 3.82 (s, 6 H, 2 MeO); 6.75 (d, 2 H, HC(5), HC(5), J = 8.6 Hz); 7.26 (dd, 2 H, HC(4), HC(4), J = 8.6 Hz, J = 1.9 Hz); 7.83 (d, 2 H, HC(2), HC(2), J = 1.9 Hz). 13C NMR (DMSO-d6), delta: 51.3 (Me, Me); 86.9 (CC); 108,8 (C(5), C(5)); 109.0 (C(3), C(3)); 116.9 (C(1), C(1)); 133.9 (C(2), C(2)); 136.0 (C(4), C(4)); 150.8 (C(6), C(6)); 167.1 (CO, CO).

The synthetic route of Methyl 2-amino-5-iodobenzoate has been constantly updated, and we look forward to future research findings.

Reference:
Article; Lozanova; Stepanov; Mel?nik; Zlokazov; Veselovsky; Russian Chemical Bulletin; vol. 68; 1; (2019); p. 64 – 67; Izv. Akad. Nauk, Ser. Khim.; 1; (2019); p. 64 – 67,4;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 452-82-4,Some common heterocyclic compound, 452-82-4, name is 1-Fluoro-2-iodo-4-methylbenzene, molecular formula is C7H6FI, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 8A 4-fluoro-3-iodobenzaldehyde A mixture of 4-fluoro-3-iodotoluene (5.0 g, 21.2 mmol) and NBS (4.2 g, 23.3 mmol) in 50 mL of CCl4 was refluxed under N2 with benzoyl peroxide (250 mg, 1.03 mmol) was heated for 3 hours. The reaction mixture was cooled to room temperature and filtered through celite, washed with benzene. The filtrate was evaporated and pumped to give the benzylbromide as a crude light brown oil.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Fluoro-2-iodo-4-methylbenzene, its application will become more common.

Reference:
Patent; Xin, Zhili; Liu, Gang; Pei, Zhonghua; Szczepankiewicz, Bruce G.; Serby, Michael D.; Zhao, Hongyu; US2004/167188; (2004); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 887266-99-1, name is 3-Fluoro-4-iodobenzonitrile, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 887266-99-1, COA of Formula: C7H3FIN

General procedure: The tetrazole compounds were prepared by a modified literature reported protocol.3 Thus, the aromatic nitrile (1.0 equiv), TBAF.3H2O (0.5 equiv) and TMS-N3 (1.5 equiv) were taken in a screw capped vial equipped with a magnetic stirrer and the resulting mixture was stirred vigorously at 85 oC. The reaction mixture was then transferred to a seperatory funnel and TBAF was removed by washing the organic phase with 1M aqueous HCl solution (20 ml). The organic phase was separated, washed with brine (20 ml) and dried over Na2SO4 and then concentrated in a rotary evaporator. The products were then purified by silica-gel (60-120 mesh) column chromatography or for some cases by recystallisation. Compound 2L was used as a crude mixture for further reaction. The compounds were then characterized by IR, NMR spectroscopy and mass spectrometry. Compounds 2A-B and 2H are reported compounds3 whereas 2C- 2G and 2I- 2L are new.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Bag, Subhendu Sekhar; Talukdar, Sangita; Anjali; Bioorganic and Medicinal Chemistry Letters; vol. 26; 8; (2016); p. 2044 – 2050;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 608-28-6, name is 2-Iodo-1,3-dimethylbenzene, This compound has unique chemical properties. The synthetic route is as follows., Safety of 2-Iodo-1,3-dimethylbenzene

General procedure: Heck coupling reactions were carried out using aryl iodides (3a-j) (1 mmol), 2-Vinyl-N-Boc-piperidine (2) (1.2 mmol), and Et3N as base (2 mmol) dissolved in 10 ml of aq.ethanol (water/ethanol = 9:1). An appropriate amount of NHC precursor (i) (0.1 mmol), Pd(OAc)2 (0.05 mmol), and TBAB (0.025 mmol) were added to this mixture. The reaction mixture was heated to 80 C for 5 hrs. The coupled product was extracted with DCM (2 x 20 ml). The combined organic layers were dried (anhydrous Na2SO4) and evaporated under reduced pressure to afford a crude product which was subjected to column chromatography to afford pure E-Olefins (4a-j).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 608-28-6.

Reference:
Article; Kankala, Shravankumar; Kankala, Ranjith Kumar; Balaboina, Ramesh; Thirukovela, Narasimha Swamy; Vadde, Ravinder; Vasam, Chandra Sekhar; Bioorganic and Medicinal Chemistry Letters; vol. 24; 4; (2014); p. 1180 – 1183;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 98-61-3,Some common heterocyclic compound, 98-61-3, name is 4-Iodobenzenesulfonyl chloride, molecular formula is C6H4ClIO2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a mixture of 7 (1.0 eq) and triethylamine (3.5 eq) in dichloromethane (10 volume), substituted sulphonyl chloride (1.2 eq) was added at 5-10 C and stirred overnight at room temperature.The completion of the reaction was confirmed by TLC. The reaction mixture was poured into separating funnel washed with water followed by brine solution, dried over anhydrous sodium sulphate and concentrated to syrup. Crude syrup was purified by crystallization using dichloromethane and petroleum ether to yield the oxadiazole substituted sulfonamide as white to white solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Iodobenzenesulfonyl chloride, its application will become more common.

Reference:
Article; Harish, Kikkeri P.; Mohana, Kikkeri N.; Mallesha, Lingappa; Prasanna Kumar, Basavapatna N.; European Journal of Medicinal Chemistry; vol. 65; (2013); p. 276 – 283;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com