Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Comparative Study, Article, Research Support, Non-U.S. Gov’t, Contraception called The action of (S)-α-chlorohydrin and 6-chloro-6-deoxyglucose on the metabolism of guinea pig spermatozoa, Author is Jones, A. R.; Ford, S. A., which mentions a compound: 60827-45-4, SMILESS is OC[C@H](O)CCl, Molecular C3H7ClO2, Product Details of 60827-45-4.
(S)-α-Chlorohydrin [60827-45-4] inhibited the conversion of D-fructose [57-48-7] to lactate [50-21-5] by mature guinea pig spermatozoa in vitro. At 2 mM, there was a specific inhibition of glyceraldehyde-phosphate dehydrogenase [9001-50-7], resulting in the accumulation of fructose 1,6-bisphosphate [488-69-7], dihydroxyacetone 3-phosphate [57-04-5], and glyceraldehyde 3-phosphate [591-59-3] and a concomitant decrease in the concentration of endogenous lactate. (R,S)-[3-36Cl]-α-chlorohydrin was metabolized by the spermatozoa to 3-chlorolactaldehyde [84709-24-0] of unknown configuration. Exogenous (R,S)-3-chlorolactaldehyde [84709-24-0] (2 mM) was an inhibitor of glyceraldehyde-phosphate dehydrogenase in guinea pig spermatozoa, whereas (R)-α-chlorohydrin [57090-45-6] (10 mM) had no significant effect on the metabolism of fructose. 6-Chloro-6-deoxyglucose [40656-44-8] (10 mM) inhibited glyceraldehyde-phosphate dehydrogenase in guinea pig spermatozoa in vitro and was metabolized to 3-chlorolactaldehyde which was presumably the (S)-isomer. The antiglycolytic actions of (S)-α-chlorohydrin and 6-chloro-6-deoxyglucose in guinea pig spermatozoa are probably due to the action of a common metabolite, (S)-3-chlorolactaldehyde [86747-03-7].
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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com