So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Jones, A. R.; Bubb, W. A.; Murdoch, S. R.; Stevenson, D. A. researched the compound: (2S)-(+)-3-Chloropropane-1,2-diol( cas:60827-45-4 ).Reference of (2S)-(+)-3-Chloropropane-1,2-diol.They published the article 《Inhibition of fructolytic enzymes in boar spermatozoa by (S)-α-chlorohydrin and 1-chloro-3-hydroxypropanone》 about this compound( cas:60827-45-4 ) in Australian Journal of Biological Sciences. Keywords: fructolysis enzyme sperm chlorohydrin isomer; chlorohydroxypropane sperm chlorolactaldehyde enzyme inhibition. We’ll tell you more about this compound (cas:60827-45-4).
When boar spermatozoa were incubated with (S)-α-chlorohydrin [60827-45-4], glyceraldehyde-3-phosphate dehydrogenase (GPD) [9001-50-7] activity was inhibited. The (R)-isomer had no effect whereas (R,S)-3-chlorolactaldehyde [84709-24-0] also inhibited GDP and lactate dehydrogenase [9001-60-9]. The in vitro production of (S)-3-chlorolactaldehyde [86747-03-7], the active metabolite of (S)-α-chlorohydrin, was attempted by incubating boar spermatozoa with 1-chloro-3-hydroxypropanone [24423-98-1]. Preliminary results indicated that this compound is converted into (S)-3-chlorolactaldehyde as well as to another metabolite which is an inhibitor of other enzymes within the fructolytic pathway.
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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com