The author of 《Synthesis of Pyrimido[5′,4′:4,5]pyrrolo[1,2-f]phenanthridines by a One-Pot C-N-Coupling/Hydroamination/C-H-Arylation Sequence》 were Ngo, Nghia Pham; Ali Salman, Ghazwan; Belattar, Nadjah; Tuan, Thanh Dang; Ehlers, Peter; Langer, Peter. And the article was published in European Journal of Organic Chemistry in 2017. Product Details of 83410-16-6 The author mentioned the following in the article:
A modular and atom-economic synthetic pathway towards 11,13-dimethylpyrimido[5′,4′:4,5]pyrrolo[1,2-f]phenanthridines is described. The protocol features a chemoselective Sonogashira reaction of a 4,5-dihalopyrimidine followed by a domino C-N coupling/hydroamination and C-H arylation that can be achieved in a one-pot process. The yields vary from moderate to good.4-Chloro-5-iodo-2,6-dimethylpyrimidine(cas: 83410-16-6Product Details of 83410-16-6) was used in this study.
4-Chloro-5-iodo-2,6-dimethylpyrimidine(cas: 83410-16-6) is one of organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Product Details of 83410-16-6
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com