In 2022,Uppalabat, Thikhamporn; Tapdara, Anyawan; Khaikate, Onnicha; Worakul, Thanapat; Surawatanawong, Panida; Leowanawat, Pawaret; Soorukram, Darunee; Reutrakul, Vichai; Meesin, Jatuporn; Kuhakarn, Chutima published an article in New Journal of Chemistry. The title of the article was 《Synthesis of indolo- and benzothieno[3,2-c]quinolines via POCl3 mediated tandem cyclization of o-alkynylisocyanobenzenes derived from o-alkynyl-N-phenylformamides》.Name: 4-Chloro-2-iodoaniline The author mentioned the following in the article:
A synthesis of indolo[3,2-c]quinolines and benzothieno[3,2-c]quinolines has been developed employing o-alkynyl-N-phenylformamide derivatives as the substrates. The reaction proceeded via a tandem process involving POCl3-assisted intramol. cyclization of the firstly formed o-alkynylisocyanobenzenes, leading to the desired products in moderate to high yields. Furthermore, the reaction is efficient on a gram-scale and the products were structurally modified by amination, Suzuki-Miyaura reaction and Heck cross-coupling. Photophys. properties of several selected indolo[3,2-c]quinolines were studied by UV-Visible and fluorescence spectroscopy and rationalized using time-dependent DFT calculations The experimental process involved the reaction of 4-Chloro-2-iodoaniline(cas: 63069-48-7Name: 4-Chloro-2-iodoaniline)
4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Name: 4-Chloro-2-iodoaniline
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com