《Palladium-catalyzed carbonylative cyclization of 2-alkynylanilines and aryl iodides to access N-acyl indoles》 was written by Yao, Lingyun; Shang, Yan; Wang, Jian-Shu; Pan, Ailin; Ying, Jun; Wu, Xiao-Feng. Electric Literature of C6H4ClI And the article was included in Organic Chemistry Frontiers in 2021. The article conveys some information:
A palladium-catalyzed carbonylative synthesis of N-acyl indoles I (R = Ph, 2-methylphenyl, 4-chloropenyl, 3,4-dimethylphenyl, etc.; R1 = Ph, 3-methylphenyl, 4-methylphenyl, 4-methoxyphenyl, 4-fluorophenyl; R2 = H, F) from 2-alkynylanilines 2-NH25-R2C6H3CCR1 and aryl iodides RI has been developed. Using benzene-1,3,5-triyl triformate (TFBen) as the CO source, the reaction produced a variety of N-acyl indoles I in a facile manner with high yields. After reading the article, we found that the author used 1-Chloro-3-iodobenzene(cas: 625-99-0Electric Literature of C6H4ClI)
1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides.Electric Literature of C6H4ClI The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com