Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons-Smith reaction (cyclopropanation using iodomethane), 1120-90-7, formula is C5H4IN, Name is 3-Iodopyridine. Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction. Category: iodides-buliding-blocks.
Oseka, Maksim;Laudadio, Gabriele;van Leest, Nicolaas P.;Dyga, Marco;Bartolomeu, Aloisio de A.;Goossen, Lukas J.;de Bruin, Bas;de Oliveira, Kleber T.;Noel, Timothy research published 《 Electrochemical Aziridination of Internal Alkenes with Primary Amines》, the research content is summarized as follows. An electrochem. approach, which realizes this concept via an oxidative coupling between alkenes RCH=CR1R2 (R = 4-methoxyphenyl, Ph, thiophen-2-yl, etc.; R1 = Ph, Me; R2 = H, Me, Ph), 7-methoxy-2,2-dimethyl-2H-chromene and 9-(phenylmethylidene)-9H-fluorene and primary alkylamines R3NH2 (R3 = H, Me, benzyl, cyclohexyl, etc.) were reported. The reaction is carried out in an electrochem. flow reactor leading to short reaction/residence times (5 min), high yields, and broad scope. At the cathode, hydrogen is generated, which can be used in a second reactor to reduce the aziridine, yielding the corresponding hydroaminated products I. Mechanistic investigations and DFT calculations revealed that the alkene is first anodically oxidized and subsequently reacted with the amine coupling partner.
Category: iodides-buliding-blocks, 3-Iodopyridine is a heteroaryl halide. It undergoes microwave-assisted coupling with heterocyclic compounds (pyrazole, imidazole, pyrrole and indole) to afford the corresponding N-3-pyridinyl-substituted heterocyclic compounds.
3-Iodopyridine is a useful research chemical used as a reactant in the copper-catalyzed coupling of alkylamines and aryl iodides.
3-Iodopyridine is an isomeric compound that can be synthesized by cross-coupling reactions. This compound has been shown to have nicotinic acetylcholine receptor binding properties and may be useful in the treatment of Alzheimer’s disease. 3-Iodopyridine is a primary amino acid that can be used for the synthesis of amines, which are nitrogen nucleophiles. It has been crystallized with halides and its x-ray structures have been determined. The nmr spectra of 3-iodopyridine show that it contains phosphorus and nitrogen atoms. 3-Iodopyridine is also able to take up nitrate ions from solution, which may be due to its uptake properties., 1120-90-7.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com