Lee, Jin Young’s team published research in Angewandte Chemie, International Edition in 45 | CAS: 31253-08-4

Angewandte Chemie, International Edition published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, Application of Ethyl 2-Iodopropionate.

Lee, Jin Young published the artcileRadical alkylation of bis(silyloxy)enamine derivatives of organic nitro compounds, Application of Ethyl 2-Iodopropionate, the publication is Angewandte Chemie, International Edition (2006), 45(37), 6182-6186, database is CAplus and MEDLINE.

Alkylation β to a nitro group by radical chem. is made possible by initial conversion of the organic nitro compound into a bis(silyloxy)enamine (TBSOTf = tert-butyldimethylsilyl trifluoromethanesulfonate). E.g., reaction of Me2CHNO2 with TBSOTf gave (TBSO)2NCMe:CH2. Irradiation of a solution of the latter, ICH2SO2Ph, and hexamethylditin gave oxime ether (E)-PhSO2CH2CH2CMe:NOTBS in 71% yield. Hydrolysis of the latter gave ketone PhSO2CH2CH2COMe in 91% yield. An advantage of the method is the simultaneous conversion of the nitro group into a synthetically useful oxime ether group.

Angewandte Chemie, International Edition published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, Application of Ethyl 2-Iodopropionate.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com