Tan, Derek S. published the artcileStereoselective Synthesis of over Two Million Compounds Having Structural Features Both Reminiscent of Natural Products and Compatible with Miniaturized Cell-Based Assays, Synthetic Route of 101-29-1, the publication is Journal of the American Chemical Society (1998), 120(33), 8565-8566, database is CAplus.
A combinatorial library of 2.18 million octahydrobenzoisoxazoles I (R = 2-I, 3-I, 4-I, 2-R4CC, 3-R4CC, 4-R4CC; R1 = alkyl, cycloalkyl, arylalkyl; R2 = alkyl, cycloalkyl, aryl, arylalkyl, heteroaryl; R3 = NH2, CH2CONH2, (CH2)5CONH2; R4 = alkyl, aryl, arylalkyl) has been generated to give a set rigid, stereochem. defined, and structurally diverse mols. The libraries are prepared in six steps from either enantiomer of oxacycloheptane II by linking to a solid support with one of three linkers, esterification and dipolar cycloaddition with arylmethyl glycine nitrones, Sonogashira coupling of the product iodoaryl derivatives with alkynes, lactone cleavage with amines, acylation of the free alcs. with acids and acyl coupling reagents, and photochem. cleavage from the resin. Sublibraries of I were prepared to test the reactivity of alkynes, amines, and acids in the preparative sequence towards I and the purity of the products generated. Libraries generated by this sequence are spatially separated and encoded, allowing for controlled release of libraries into solution and for cell-based testing of the libraries.
Journal of the American Chemical Society published new progress about 101-29-1. 101-29-1 belongs to iodides-buliding-blocks, auxiliary class Pyridine,Iodide,Carboxylic acid,Ketone, name is 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid, and the molecular formula is C4H10OS, Synthetic Route of 101-29-1.
Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com