Month: November 2022

Nie, Zaicheng published the artcileCopper-Catalyzed Radical Enantioselective Carbo-Esterification of Styrenes Enabled by a Perfluoroalkylated-PyBox Ligand, Related Products of iodides-buliding-blocks, the publication is Angewandte Chemie, International Edition (2022), 61(28), e202202077, database is CAplus and MEDLINE.

Chiral lactones are found in many natural products. The reaction of simple alkenes with iodoacetic acid is a powerful method to build lactones, but the enantioselective version of this reaction has not been implemented to date. Herein, the efficient catalytic radical enantioselective carbo-esterification of styrenes enabled by a newly developed CuI-perfluoroalkylated PyBox system was reported. Simple styrenes have been converted to useful chiral lactones, whose synthetic applications are showcased. Mechanistic studies reveal that this reaction is a rare example of an efficient ligand-decelerated system, in which the ligand decelerates the reaction, but the reaction is still efficient with reduced amounts of ligand. This uncommon catalytic system may inspire further consideration of the effect of ligands in asym. catalysis.

Angewandte Chemie, International Edition published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Related Products of iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Yu, Bole published the artcileRhodium-catalyzed C-H activation of hydrazines leads to isoquinolones with tunable aggregation-induced emission properties, Recommanded Product: 4-Iodobenzohydrazide, the publication is Chemical Communications (Cambridge, United Kingdom) (2015), 51(76), 14365-14368, database is CAplus and MEDLINE.

Using an internally oxidizing directing group (DG) strategy, the authors report a Rh^III-catalyzed synthesis of isoquinolones via C-H activation/annulation of benzoylhydrazines and alkynes. Tunable double cascade cyclization of benzoylhydrazines with two equivalent of alkynes led to tetracyclic amides. These N-heterocycles demonstrated adjustable AIE properties.

Chemical Communications (Cambridge, United Kingdom) published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C42H63O3P, Recommanded Product: 4-Iodobenzohydrazide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Yu, Gang published the artcileSynthesis and bioactivity of sulfide derivatives containing 1,3,4-oxadiazole and pyridine, Category: iodides-buliding-blocks, the publication is Turkish Journal of Chemistry (2019), 43(4), 1075-1085, database is CAplus.

A series of novel sulfide derivatives containing 1,3,4-oxadiazole and pyridine were synthesized, characterized, and tested for their antibacterial activity against tobacco bacterial wilt and rice bacterial blight and for insecticidal activity toward diamondback moth. The results showed that some compounds had good insecticidal and bactericidal activity, e.g., the activities of compounds 6e and 6g-6j toward tobacco bacterial wilt were much better than those of com. thiodiazole-copper, and some of the synthesized compounds possessed good insecticidal activity against Plutella xylostella. Compounds 6d, 6h, 6j, 6l, 6p, 6r, and 6p displayed over 93% activity at 500 mg L^-1.

Turkish Journal of Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H5ClN2S, Category: iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Feng, Zhang published the artcileCopper Catalyzed Cross-Coupling of Iodobenzoates with Bromozinc-difluorophosphonate, HPLC of Formula: 165534-79-2, the publication is Organic Letters (2012), 14(7), 1938-1941, database is CAplus and MEDLINE.

A Cu-catalyzed cross-coupling of iodobenzoates with bromozinc-difluorophosphonate, generated from di-Et bromodifluoromethylphosphonate and Zn in dioxane, is reported. The notable features of this reaction are its high reaction efficiency, excellent functional group compatibility, and operational simplicity. This protocol provides a useful and facile access to aryldifluorophosphonates of interest in life science.

Organic Letters published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C10H9IO4, HPLC of Formula: 165534-79-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Bao, Wenhu published the artcileSynthesis of 2-Amino-1,3,4-oxadiazoles through Elemental Sulfur Promoted Cyclization of Hydrazides with Isocyanides, Related Products of iodides-buliding-blocks, the publication is Chinese Journal of Chemistry (2017), 35(10), 1611-1618, database is CAplus.

A novel sulfur-promoted cyclization of hydrazides and isonitriles to produce 1,3,4-oxadiazoles has been developed. The method is operationally simple and compatible with a wide scope of substrates and various 2-amino-1,3,4-oxadiazoles are efficiently obtained in good yields.

Chinese Journal of Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Related Products of iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Niranjan, M. S. published the artcileSynthesis of 1,3,4-oxadiazole incorporated thiofibrates from substituted benzoic acids, Category: iodides-buliding-blocks, the publication is World Journal of Pharmacy and Pharmaceutical Sciences (2017), 6(11), 1085-1093, database is CAplus.

The present article describes the synthesis of 1,3,4-oxadiazole incorporated thiofibrates I (R = 4-NO₂, 4-Cl, 4-I, 3-Br, 4-Br) from substituted benzoic acids. Substituted benzoic acids reacted with methanol to obtain corresponding Me esters which was further converted into hydrazides by refluxing with hydrazine hydrate. Reaction of the above hydrazides with carbon disulfide in 10% potassium hydroxide yielded corresponding thiophenols incorporated with 1,3,4-oxadiazole. Ethyl-2-bromoisobutyrate in DMF converts these thiophenols into thiofibrates in presence of anhydrous potassium carbonate.

World Journal of Pharmacy and Pharmaceutical Sciences published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Category: iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Kornblum, Nathan published the artcileThe reaction of silver nitrite with α-halo esters, Recommanded Product: Ethyl 2-Iodopropionate, the publication is Journal of the American Chemical Society (1955), 6654-5, database is CAplus.

MeCHICO₂Et (I), b₇ 49°, n_D²⁰ 1.4963, (68.7 g.) added dropwise with stirring to 92.4 g. AgONO suspended in 500 cc. dry Et₂O during 1.5 h., the mixture stirred 48 h. at room temperature, and filtered, the filter residue washed with dry Et₂O, the combined filtrate and washings evaporated, and the residual pale blue oil distilled yielded 35.3 g. MeCH(NO₂)CO₂Et, b₉ 75-6°, n_D²⁰ 1.4210; it was readily recovered in 90% yield from a solution in saturated aqueous NaHCO₃ by acidification with aqueous AcOH containing urea. ICH₂CO₂Et, b₃ 60° n_D²⁰ 1.5045, yielded similarly during 48 h. 77% O₂NCH₂CO₂Et, b₃ 71-2°, n_D²⁰ 1.4245. EtCHICO₂Et, b₁ 46°, n_D²⁰ 1.4923, gave in the same manner during 54 h. 75% EtCH(NO₂)CO₂Et, b₈ 82-3%, n_D²⁰ 1.4233. BuCHICO₂Et, b₄ 84°, n_D²⁰ 1.4873, gave during 144 h. 84% BuCH(NO₂)CO₂Et, b₃ 80-1°, n_D²⁰ 1.4302. Me₂CHI (5.95 g.) and 200 cc. Et₂O stirred with cooling in ice, after 1 h. 1-cc. samples in duplicate withdrawn to give the initial concentration of iodide, the solution treated with 53.9 g. AgONO as rapidly as possible, and the reaction followed by converting the unreacted Me₂CHI in 1-cc. aliquots with Raney Ni to ionic iodide and titrating as such with AgNO₃; the reaction was 50% completed in 8 min. The similar reaction of I with AgONO was 50% over in 4860 min. BrCH₂CO₂Et (50.1 g.) treated 6.5 days with 48.5 g. AgONO at 25-8° gave 40.1 g. unreacted I.

Journal of the American Chemical Society published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, Recommanded Product: Ethyl 2-Iodopropionate.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Longobardo, Luigi published the artcileNovel thiol- and thioether-containing amino acids: cystathionine and homocysteine families, Synthetic Route of 161370-66-7, the publication is Amino Acids (2013), 44(2), 443-448, database is CAplus and MEDLINE.

Natural L-homocysteine and L,L-cystathionine, along with a series of unnatural analogs, have been prepared from L-aspartic and L-glutamic acids. Manipulation of the protected derivatives provided ω-iodoamino acids, which were used in thioalkylation reactions of sulfur nucleophiles, such as the ester of L-cysteine and potassium thioacetate.

Amino Acids published new progress about 161370-66-7. 161370-66-7 belongs to iodides-buliding-blocks, auxiliary class Chiral,Iodide,Amine,Aliphatic hydrocarbon chain,Ester,Amide, name is (S)-tert-Butyl 2-((tert-butoxycarbonyl)amino)-4-iodobutanoate, and the molecular formula is C13H24INO4, Synthetic Route of 161370-66-7.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Gnocchi, Davide published the artcileXanthenylacetic Acid Derivatives Effectively Target Lysophosphatidic Acid Receptor 6 to Inhibit Hepatocellular Carcinoma Cell Growth, Related Products of iodides-buliding-blocks, the publication is ChemMedChem (2021), 16(13), 2121-2129, database is CAplus and MEDLINE.

Despite the increasing incidence of hepatocellular carcinoma (HCC) worldwide, current pharmacol. treatments are still unsatisfactory. We have previously shown that lysophosphatidic acid receptor 6 (LPAR6) supports HCC growth and that 9-xanthenylacetic acid (XAA) acts as an LPAR6 antagonist inhibiting HCC growth without toxicity. Here, we synthesized four novel XAA derivatives, (±)-2-(9H-xanthen-9-yl)propanoic acid (compound 4 – MC9), (±)-2-(9H-xanthen-9-yl)butanoic acid (compound 5 – MC6), (±)-2-(9H-xanthen-9-yl)hexanoic acid (compound 7 – MC11), and (±)-2-(9H-xanthen-9-yl)octanoic acid (compound 8 – MC12, sodium salt) by introducing alkyl groups of increasing length at the acetic α-carbon atom. Two of these compounds were characterized by X-ray powder diffraction and quantum mech. calculations, while mol. docking simulations suggested their enantioselectivity for LPAR6. Biol. data showed anti-HCC activity for all XAA derivatives, with the maximum effect observed for MC11. Our findings support the view that increasing the length of the alkyl group improves the inhibitory action of XAA and that enantioselectivity can be exploited for designing novel and more effective XAA-based LPAR6 antagonists.

ChemMedChem published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Related Products of iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Perez-Ojeda, M. Eugenia published the artcileCarbon nano-onions: Potassium intercalation and reductive covalent functionalization, COA of Formula: C6H13I, the publication is Journal of the American Chemical Society (2021), 143(45), 18997-19007, database is CAplus and MEDLINE.

Herein we report the synthesis of covalently functionalized carbon nano-onions (CNOs) via a reductive approach using unprecedented alkali-metal CNO intercalation compounds For the first time, an in situ Raman study of the controlled intercalation process with potassium has been carried out revealing a Fano resonance in highly doped CNOs. The intercalation was further confirmed by electron energy loss spectroscopy and X-ray diffraction. Moreover, the exptl. results have been rationalized with DFT calculations Covalently functionalized CNO derivatives were synthesized by using Ph iodide and n-hexyl iodide as electrophiles in model nucleophilic substitution reactions. The functionalized CNOs were exhaustively characterized by statistical Raman spectroscopy, thermogravimetric anal. coupled with gas chromatog. and mass spectrometry, dynamic light scattering, UV-vis, and ATR-FTIR spectroscopies. This work provides important insights into the understanding of the basic principles of reductive CNOs functionalization and will pave the way for the use of CNOs in a wide range of potential applications, such as energy storage, photovoltaics, or mol. electronics.

Journal of the American Chemical Society published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, COA of Formula: C6H13I.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com