Month: November 2022

Lima, Eurico published the artcilePicolylamine-functionalized benz[e]indole squaraine dyes: Synthetic approach, characterization and in vitro efficacy as potential anticancer phototherapeutic agents, Application of 1-Iodohexane, the publication is European Journal of Medicinal Chemistry (2022), 114071, database is CAplus and MEDLINE.

Squaraine dyes are a family of compounds known for their relevant photophys. and photochem. properties potentially useful as photosensitizing agents. Since pyridines have been introduced into the skeleton of several families of compounds to enhance their pharmacol. activity, and this approach had not yet been performed on squaraines, novel dyes derived from benz[e]indole functionalized with picolyl- and dipicolylamine and N-Et and -hexyl chains were designed and synthesized. After being fully characterized, their interaction with human albumin was in vitro and in silico evaluated. Dyes were further assessed for their phototoxicity activity, and the most interesting ones were studied regarding cell localization and induction of morphol. cell changes, genotoxicity, apoptosis and cell cycle arrest. The mols. with N-Et chains showed the greatest in vitro light-dependent cytotoxic effects, particularly the zwitterionic squaraine dye and the one bearing a single pyridine unit, which also exhibited a more significant interaction with human albumin. Phenotypically, the cells incubated with these squaraines became smaller and rounded after irradiation, the effects varying with the tested concentration Genotoxic effects were observed even without irradiation, being more evident for the N-Et picolylamine-derived dye. The fluorescence emitted by Rhodamine 123 largely coincided with that emitted by the dyes, suggesting that they are found preferentially in mitochondria. After irradiation, an increase in the subG1 population was verified by propidium iodide-staining anal. by flow cytometry, indicative of cell death by apoptosis.

European Journal of Medicinal Chemistry published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Application of 1-Iodohexane.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Mason, Stephen J. published the artcileSolid-phase catch, activate, and release synthesis of cyanine dyes, Recommanded Product: 1-Ethyl-2-methylquinolin-1-ium iodide, the publication is Organic Letters (2002), 4(24), 4261-4264, database is CAplus and MEDLINE.

Trimethine cyanine dyes were synthesized by capture and activation of a hemicyanine intermediate on a sulfonyl chloride resin followed by reaction and concomitant cleavage by a heterocyclic carbon nucleophile. A small array of dyes was synthesized and characterized to demonstrate the versatility of this chem. for a number of hemicyanines and heterocyclic nucleophiles.

Organic Letters published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Recommanded Product: 1-Ethyl-2-methylquinolin-1-ium iodide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Tseng, Chih-Chung published the artcileThe Trifluoromethyl Group as a Bioisosteric Replacement of the Aliphatic Nitro Group in CB₁ Receptor Positive Allosteric Modulators, HPLC of Formula: 101420-79-5, the publication is Journal of Medicinal Chemistry (2019), 62(10), 5049-5062, database is CAplus and MEDLINE.

3-Nitroalkyl-2-phenylindoles were prepared as analogs of known CB₁ receptor pos. allosteric modulators; related 3-(trifluoroalkyl)-2-phenylindoles such as I were prepared to test if the trifluoromethyl group could act as a bioisostere of the nitro group. The trifluoromethyl-bearing compounds were generally more potent than their nitro equivalent and also showed improved in vitro metabolic stability. The racemate of I has similar activity to the known CB₁ receptor pos. allosteric modulator (±)-ZCZ011, with both showing promising efficacy in a mouse model of neuropathic pain.

Journal of Medicinal Chemistry published new progress about 101420-79-5. 101420-79-5 belongs to iodides-buliding-blocks, auxiliary class Nitrile,Nitro Compound,Iodide,Benzene,Benzene Compounds, name is 4-Iodo-3-nitrobenzonitrile, and the molecular formula is C6H8O4, HPLC of Formula: 101420-79-5.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Liu, Zhiru published the artcileStructure-property relationship of poly(2,6-dimethyl-1,4-phenylene oxide) anion exchange membranes with pendant sterically crowded quaternary ammoniums, Recommanded Product: 1-Iodohexane, the publication is Journal of Membrane Science (2021), 119693, database is CAplus.

Steric hindrance engineering is of great significance to the preparation of new stable organic cations and durable polymeric anion exchange membrane materials. In this work, we presented a study of the structure-property relationship in quaternized poly (2,6-dimethyl-1,4-phenylene oxide) containing bulky Pr, iso-Pr, or cyclohexyl-functionalized quaternary ammonium moieties. To our surprise, PPO-iP membranes possessing isopropyl-based QA cations showed higher water uptake than n-propyl- and cyclohexyl-containing analogs (PPO-nP and PPO-CH), in which obvious microphase-separated morphol. was found. Thus, PPO-iP membranes displayed the highest hydroxide conductivity at 20°C in water (37.3 mS/cm, IEC = 1.90 mmol/g). A standard protocol (1 M or 2 M NaOH at 60°C) was used to determine the chem. stability of model cations and membranes both having sterically crowded QAs. Minor loss (<2%) in conductivity was observed for PPO-CH membranes after the treatment in 2 M NaOH at 60°C for 216 h, highlighting the excellent alk. stability, while significant degradation of PPO-iP and PPO-nP was confirmed by NMR characterization of the aged samples. In addition, the prepared PPO-based AEMs having sterically crowded QA cations were compared in alk. H₂/O₂ fuel cells, demonstrating that the highly conductive PPO-iP membrane exhibited a peak power d. of 182 mW/cm² under optimized testing conditions.

Journal of Membrane Science published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Recommanded Product: 1-Iodohexane.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Schuiten, Eva D. published the artcilePromiscuous dehalogenase activity of the epoxide hydrolase CorEH from Corynebacterium sp. C12, Related Products of iodides-buliding-blocks, the publication is ACS Catalysis (2021), 11(10), 6113-6120, database is CAplus.

Haloalkane dehalogenases and epoxide hydrolases are phylogenetically related and structurally homologous enzymes that use nucleophilic aspartate residues for an S_N2 attack on their substrates. Despite their mechanistic similarities, no enzymes are known that exhibit both epoxide hydrolase and dehalogenase activity. We screened a subset of epoxide hydrolases, closely related to dehalogenases, for dehalogenase activity and found that the epoxide hydrolase CorEH from Corynebacterium sp. C12 exhibits promiscuous dehalogenase activity. Compared to the hydrolysis of epoxides like cyclohexene oxide (1.41μmol min^-1 mg^-1), the dehalogenation of haloalkanes like 1-bromobutane (0.25 nmol min^-1 mg^-1) is about 5000-fold lower. In addition to the activity with 1-bromobutane, dehalogenase activity was detected with other substrates like 1-bromohexane, 1,2-dibromoethane, 1-iodobutane, and 1-iodohexane. This study shows that dual epoxide hydrolase and dehalogenase activity can be present in one naturally occurring protein scaffold.

ACS Catalysis published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is 0, Related Products of iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Cartagenova, Daniele published the artcileHighly selective Suzuki reaction catalyzed by a molecular Pd-P-MOF catalyst under mild conditions: role of ligands and palladium speciation, Category: iodides-buliding-blocks, the publication is Catalysis Science & Technology (2022), 12(3), 954-961, database is CAplus.

A molecularly-defined heterogeneous palladium catalyst based on a phosphine-metal-organic framework (P-MOF) ligand system was reported. This catalyst performed Suzuki reactions of aryl bromides and Ph boronic acid to afford biaryls R-R¹ [R = Ph; R¹ = 3-MeC₆H₄, 3-OMeC₆H₄, 3-pyridyl, etc.] in exceptionally mild conditions while displayed a unique selectivity, higher than that achieved using Pd(PPh₃)₄, a standard homogeneous catalyst. The new palladium P-MOF catalyst was active for a wide range of substrates. Determination of the palladium speciation showed that molecularly-defined palladium-phosphine sites catalyzed the Suzuki cross-coupling with very high selectivity, and that, when formed, palladium nanoparticles promoted hydrodehalogenation. The fraction of molecularly defined palladium was maximized by having excess of phosphine ligand in the system.

Catalysis Science & Technology published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C10H9IO4, Category: iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Patnaik, Anup published the artcileDiscovery of a novel indole pharmacophore for the irreversible inhibition of myeloperoxidase (MPO), Application of 4-Iodo-3-(trifluoromethyl)-1H-pyrazole, the publication is Bioorganic & Medicinal Chemistry (2020), 28(12), 115548, database is CAplus and MEDLINE.

Myeloperoxidase (MPO) activity and subsequent generation of hypochlorous acid has been associated with the killing of host-invading microorganisms (e.g. bacteria, viruses, and fungi). However, during oxidative stress, high MPO activity can damage host tissue and is linked to several chronic inflammatory conditions. Herein, we describe the development of a novel biaryl, indole-pyrazole series of irreversible mechanism-based inhibitors of MPO. Derived from an indole-containing high-throughput screen hit, optimization efforts resulted in potent and selective 6-substituted indoles with good oral bioavailability and in vivo activity.

Bioorganic & Medicinal Chemistry published new progress about 866638-72-4. 866638-72-4 belongs to iodides-buliding-blocks, auxiliary class Trifluoromethyl,Pyrazole,Fluoride,Iodide, name is 4-Iodo-3-(trifluoromethyl)-1H-pyrazole, and the molecular formula is C4H2F3IN2, Application of 4-Iodo-3-(trifluoromethyl)-1H-pyrazole.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Denny, William A. published the artcilePotential antitumor agents. Part 38. 3-Substituted 5-carboxamido derivatives of amsacrine, Recommanded Product: 2-Chloro-4-iodobenzoic acid, the publication is Journal of Medicinal Chemistry (1983), 26(11), 1619-25, database is CAplus and MEDLINE.

The title compounds I (R = Cl, NH₂, NO₂, Me, or MeO; R¹ = CONH₂, CONHMe, CONHCH₂CONH₂, or p-CO₂C₆H₄NO₂) as the HCl salt prepared by the reaction of a halobenzoic acid with an aminobenzoate ester, ring closure of the half ester formed with polyphosphate ester to an acridanone ester, slow hydrolysis to the acid, conversion to the appropriate chloro derivative and reaction with 4-aminomethanesulfon-m-anisidide  [57165-06-7], and I (R = H, Br, Cl, I, NH₂, NO₂, Me, or MeO; R¹ = H, CONH₂, CONHMe) were evaluated for in vivo activity against animal leukemia models. Structure-activity relations are discussed.

Journal of Medicinal Chemistry published new progress about 145343-76-6. 145343-76-6 belongs to iodides-buliding-blocks, auxiliary class Chloride,Iodide,Carboxylic acid,Benzene, name is 2-Chloro-4-iodobenzoic acid, and the molecular formula is C7H4ClIO2, Recommanded Product: 2-Chloro-4-iodobenzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Shaikh, Zara published the artcileChemistry and antioxidant properties of titanium(IV) complexes, COA of Formula: C7H7IN2O, the publication is Transition Metal Chemistry (Dordrecht, Netherlands) (2015), 40(6), 665-671, database is CAplus.

The synthesis of Ti(IV) complexes with biol. active hydrazide ligands was carried out. The complexes were characterized by spectroscopic methods (IR, ¹H NMR and ¹³C NMR), elemental anal. and conductivity studies. These studies suggest bidentate coordination of the ligands through carbonyl O and primary amine N, resulting in octahedral geometries. Hydrazides with pyridyl substituents displayed 1:2 metal-to-ligand ratio, and hydrazides with imino substituents exhibited 1:3 metal-to-ligand ratio resulting in an outer sphere complex. The remaining complexes displayed inner sphere coordination with 1:1 metal-to-ligand ratio. These complexes exhibit varying degrees of radical scavenging properties against DPPH, superoxide and nitric oxide free radicals. The free ligands showed inhibition against DPPH, but were inactive against superoxide and nitric oxide free radicals. The structure-activity relations of the complexes are discussed.

Transition Metal Chemistry (Dordrecht, Netherlands) published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C6H8O4, COA of Formula: C7H7IN2O.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Jamal, Rifat Ara published the artcile4-Iodobenzohydrazide, Formula: C7H7IN2O, the publication is Acta Crystallographica, Section E: Structure Reports Online (2008), 64(11), o2188, o2188/1-o2188/7, database is CAplus and MEDLINE.

In the structure of the title compound, C₇H₇IN₂O, the hydrazide group is inclined at 13.3 (3)° with respect to the benzene ring. The structure is stabilized by intermol. N-H···N and N-H···O hydrogen bonds involving the hydrazide group, resulting in six- and ten-membered rings with R₂²(6) and R₂²(10) graph-set notations, resp. Crystallog. data are given.

Acta Crystallographica, Section E: Structure Reports Online published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Formula: C7H7IN2O.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com