Month: November 2022

Saleh, Tamer S. published the artcileSonochemical synthesis of novel pyrano[3,4-e][1,3]oxazines: A green protocol, Safety of 4-Iodobenzohydrazide, the publication is Ultrasonics Sonochemistry (2017), 474-480, database is CAplus and MEDLINE.

The atom-efficient and green protocol for formation of pyrano[3,4-e][1,3]oxazines I [R = n-Bu, NHPh, cyclohexyl, etc.] via reaction of di-Me carbonate and 3-(1-(substituted imino)ethyl)-4-hydroxy-6-methyl-2H-pyran-2-ones under ultrasound irradiation in a presence of KF/basic alumina was reported. In general, it was found that ultrasound irradiations enable the reactions to occur which could not be carried out under silent conditions. These remarkable effects appeared in sonicated reactions could be reasonably interpreted in terms of acoustic cavitation phenomenon. This protocol offered several advantages attain many principles of green chem. including, save energy, atom economy, clean reactions, inexpensive green reagent and use catalysts rather than stoichiometric reagents.

Ultrasonics Sonochemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Safety of 4-Iodobenzohydrazide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhao, Fengqian published the artcileCopper-Catalyzed Substrate-Controlled Carbonylative Synthesis of α-Keto Amides and Amides from Alkyl Halides, Synthetic Route of 638-45-9, the publication is Angewandte Chemie, International Edition (2022), 61(17), e202200062, database is CAplus and MEDLINE.

Controllable production of α-keto amides and amides from the same substrates is an attractive goal in the field of transition-metal-catalyzed (double-)carbonylation. A novel copper-catalyzed highly selective double carbonylation of alkyl bromides was developed. Moderate to good yields of α-keto amides were obtained as the only products. In the case of alkyl iodides, double- and mono-carbonylation can be achieved controllably under different conditions.

Angewandte Chemie, International Edition published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C40H35N7O8, Synthetic Route of 638-45-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Morshedy, M. published the artcileInhibition of monoamine oxidase by benzoyl hydrazide derivatives, Recommanded Product: 4-Iodobenzohydrazide, the publication is Alexandria Science Exchange (1986), 7(1), 33-8, database is CAplus.

The in vitro inhibition of mitochondrial rat liver monoamine oxidase (MAO) activity by synthetic benzoyl hydrazide (I) derivatives was studied. The tested compounds were unsubstituted I and 2- and 4-chloro-I, 2-, 3-, and 4-methyl-I, 2- and 4-iodo-I, 4-methoxy- and 2-nitro-I. 4-Methyl- and 4-chloro-I exhibited a strong inhibitory effect for MAO activity, whereas unsubstituted I was the lowest one. On the other hand, all of the substitution in the benzoyl moiety caused good improvement in the inhibitory power of the I derivative, especially the ortho-para director groups or atoms.

Alexandria Science Exchange published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Recommanded Product: 4-Iodobenzohydrazide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Sarver, Patrick published the artcile6-Amino-3-methylpyrimidinones as Potent, Selective, and Orally Efficacious SHP2 Inhibitors, Quality Control of 2055760-88-6, the publication is Journal of Medicinal Chemistry (2019), 62(4), 1793-1802, database is CAplus and MEDLINE.

Protein tyrosine phosphatase SHP2 is an oncoprotein associated with cancer as well as a potential immune modulator because of its role in the programmed cell death PD-L1/PD-1 pathway. In the preceding manuscript, we described the optimization of a fused, bicyclic screening hit for potency, selectivity, and physicochem. properties in order to further expand the chem. diversity of allosteric SHP2 inhibitors. In this manuscript, we describe the further expansion of our approach, morphing the fused, bicyclic system into a novel monocyclic pyrimidinone scaffold through our understanding of SAR and use of structure-based design. These studies led to the identification of SHP394 (1), an orally efficacious inhibitor of SHP2, with high lipophilic efficiency, improved potency, and enhanced pharmacokinetic properties. We also report other pyrimidinone analogs with favorable pharmacokinetic and potency profiles. Overall, this work improves upon our previously described allosteric inhibitors and exemplifies and extends the range of permissible chem. templates that inhibit SHP2 via the allosteric mechanism.

Journal of Medicinal Chemistry published new progress about 2055760-88-6. 2055760-88-6 belongs to iodides-buliding-blocks, auxiliary class Pyrimidine, name is 2-Chloro-5-iodo-3-methylpyrimidin-4(3H)-one, and the molecular formula is C5H4ClIN2O, Quality Control of 2055760-88-6.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Abusaif, Moustafa S. published the artcileEffect of different acceptors on N-hexyl carbazole moiety for dye-sensitized solar cells: design, characterization, molecular structure, and DSSC fabrications, Computed Properties of 638-45-9, the publication is Journal of the Iranian Chemical Society (2021), 18(4), 949-960, database is CAplus.

Hexyl carbazole derivatives are one of the most prominent dye scaffolds in the dye-sensitized solar cells (DSSCs). New substituted carbazole dyes such as DRA-HC, DCA-HC, and DTC-HC were synthesized for DSSCs. These dyes are containing hexyl moiety as electron donor and rhodanine-3-acetic acid, cyanoacetic acid and tetracyanoethylene as an electron acceptor linked to carbazole moiety. The relation between dye structures, photophys./electrochem., mol. structure and DSSC manufacturing had been discussed. All structures showed more pos. ground-state oxidation potential than I-/I-3 and more neg. excited state oxidation potential than the conduction band edge of the semiconductor. The highest efficiency of the DSSCs was obtained in the case of DCA-HC dye (η = 1.41%, VOC = 708 mV, FF = 0.81, and JSC = 2.45 mA cm^-2 with 100 mW cm^-2) compared to other synthesized dyes.

Journal of the Iranian Chemical Society published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Computed Properties of 638-45-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Hossan, Aisha published the artcileSynthesis, self-assembly and optical properties of novel fluorescent alkoxy-substituted fluoroaryl 1, 3, 4-oxadiazole organogelator, Safety of 1-Iodohexane, the publication is Arabian Journal of Chemistry (2022), 15(5), 103771, database is CAplus.

A series of fluoroaryl 1,3,4-oxadiazole derivatives I [R = Et, hexyl, decyl] substituted with different para terminal ethers were synthesized using S_NAr chem. to afford fluorescent and thermally reversible low mol. weight organogelators (LMWOs). S_NAr was used to synthesize these highly fluorinated organogelators in high purity and good yields starting from pentafluorobenzoic acid and 4′-hydroxy-4-biphenylcarbonitrile. These fluorinated 1,3,4-oxadiazole derivatives were characterized by elemental anal., FTIR and ¹H, ¹³C and ¹⁹F NMR spectroscopy. The photophys. properties of those organogelators were described. Both UV-visible absorption and fluorescence spectral profiles displayed a solvatochromic and solvatofluorochromic properties. The absorption maxima for the developed organogelators were monitored in the range of 260-289 nm, whereas the emission maxima were monitored in the range of 278-305 nm. The best gelation properties were monitored for the compound I [R = hexyl] in different solvents with critical gel concentrations in the range of 1.86-5.07 mM. The self-assembly process was monitored to occur via van der Waals forces and π-π stacks to result in gelation of solvents. Scanning electron microscope (SEM) demonstrated nanofiber-like structures (350-550 nm). The thermal stability of the compound I [R = hexyl] was monitored at 48°C. Both cytotoxicity and antimicrobial activity of the produced fluoroaryl 1,3,4-oxadiazole derivatives were explored to verify their potential use for biomedical applications, such as drug delivery and bioimaging.

Arabian Journal of Chemistry published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Safety of 1-Iodohexane.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

El-Deen Mohamed, Naglaa Salah published the artcileSynthesis, spectroscopic and antimicrobial studies of some novel cyanine dyes based on bis-coumarin heterocycles derivatives, Synthetic Route of 606-55-3, the publication is European Journal of Chemistry (2016), 7(1), 66-72, database is CAplus.

Novel sym. and unsym. cyanine dyes, incorporating merocyanine monomethine like, pentamethine cyanine, monomethine-meso-substituted-pentamethine and mono-5[2(4)]-methine cyanine dye were prepared through the synthesis of new starting compound derivatives named as 1,3-bis-(2-oxo-2H-chromen-3-yl) propane-1,3-dione and (3-oxo1,3-bis(2-oxo-2H-chromen-3-yl)prop-1-enyloxy) copper, cobalt and nickel chloride salt complexes. Structure determination of the new compounds has been characterized on the basis of elemental anal., IR, ¹H NMR and MS spectra. Structure photosensitization relationship of new dyes have been discussed on the basis of their spectral behavior as criteria of photosensitizing effect through the UV visible-absorption spectra of all synthesized dyes which investigated in 95% ethanol. Antimicrobial properties of some selected cyanine dyes have been investigated against Streptococcus sp, Staphylococcus sp, Salmonella sp. and Shigella sp.

European Journal of Chemistry published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Synthetic Route of 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Qurrat-ul-Ain published the artcileMulti-activity tetracoordinated pallado-oxadiazole thiones as anti-inflammatory, anti-Alzheimer, and anti-microbial agents: Structure, stability and bioactivity comparison with pallado-hydrazides, Application In Synthesis of 39115-95-2, the publication is Biomedicine & Pharmacotherapy (2022), 112561, database is CAplus and MEDLINE.

Herein, we report a comparative study based on structure, thermal and solution stability, and biopotency against lipoxygenase (LOX), butyrylcholinesterase (BChE) and microbes for Pd(II) compounds of N,O,S bearing 5-(C₅H₄XR)-1,3,4-oxadiazole-2-thiones (L′) of type [PdL′Cl₂] (P′n) and N,O bearing resp. hydrazides (L) of type trans-[PdL₂Cl₂] (Pn) {X = C, R = 4-I, 2-Br, 4-NO₂, 3-NO₂, 2-Cl, 3-Cl (n = 1-6, serially); X = N (n = 7)}. Spectral techniques (IR, EI-MS, NMR) and physicochem. evaluations successfully characterized the new compounds The L′ behaved as bidentate S-N donors bonded through exocyclic sulfur and N-3′ nitrogen, while L acted as amino N donors. UV-vis (solution speciation) and thermal degradation profiles consistently confirmed the greater stability for P′n than Pn compounds These compounds manifested varying degree in vitro potential to inhibit LOX, BChE and several bacteria and fungi, affected mainly by Pd(II) presence, M-L binding mode, nature and position of R, or halo groups electronegativity. Mol. docking with human 5-LOX and BChE further validated the resp. exptl. inhibition findings and explored several putative mechanistic interactions (H-bonding, π-stacking, π-alkyl, π-S, etc.) at the enzyme active sites. Pn generally offered superior antimicrobial and anti-LOX (anti-inflammatory) potential than resp. P′n compounds, with P3/P′5, P(2,3,7)/P′3, and P6 being comparable, better and equivalent to ampicillin, nystatin and baicalein, the reference antibacterial, antifungal and anti-LOX drugs, resp. Contrarily, the anti-BChE activity of P′n was found better than Pn compounds, showing P′2/P1 as the most promising anti-Alzheimer drug candidates. This study bares important structural and mechanistic aspects in optimizing antimicrobial, anti-inflammatory and anti-Alzheimer activities, highlighting some potential future pallado-drug candidates.

Biomedicine & Pharmacotherapy published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Application In Synthesis of 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Koraiem, Ahmed I. published the artcileSynthesis and photophysical characterization of highly stable cyanine dyes based on pyrazolo[5,4-b]pyrido[2,1-c]pyrimidine and pyrazolo [5,4-b]pyrido[2,1-d][1,3,4] triazepine, Recommanded Product: 1-Ethyl-2-methylquinolin-1-ium iodide, the publication is Journal of Applicable Chemistry (Lumami, India) (2018), 7(4), 821-834, database is CAplus.

Outstanding stable cyanine dyes covering the types of monomethine, trimethine, styryl, azastyryl and apocyanines with absorption band reached to 550 nm have been developed and synthesized. These dyes based on high stable N-bridgehead heterocycles namely Pyrazolo[5,4-b]pyrido[2,1-c] pyrimidine, pyrazolo[5,4-b]pyrido[2,1-d][1,3,4] triazepines as precursors for the synthesis of the target dyes. The absorption spectra properties of such selected dyes were investigated in 95% ethanol to attempt and throw some light on the influence of such new heterocyclic nuclei and to compare or evaluate spectral behaviors. Such Heterocyclic precursors and related dyes were identified by elemental and spectral analyzes.

Journal of Applicable Chemistry (Lumami, India) published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Recommanded Product: 1-Ethyl-2-methylquinolin-1-ium iodide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

El Ashry, El Sayed H. published the artcileHeterocycles from carbohydrate precursors. Part XI. Transformation of the hydrazones of 6-chloro-3-(L-threo-2,3,4-trihydroxy-1-oxobutyl)-2-quinoxalinone into other heterocyclic compounds, COA of Formula: C7H7IN2O, the publication is Carbohydrate Research (1978), 67(2), 403-14, database is CAplus.

The difference in reactivity of the two amino groups in 3,4-(H₂N)₂C₆H₃Cl allowed it to react with L–threo-2,3-hexodiulosono-1,4-lactone to give, after further reaction with various hydrazines, quinoxalinones I (R = 4-R¹C₆H₄, 4-R²C₆H₄CO; R¹ = Me, OMe, Br, I, NO₂, SO₂NH₂, R² = H, Me, Cl, I), whose structures were deduced from their reactions, as well as from mass spectrometry of the p-nitrophenylhydrazones. Elimination of one mol of water per mol from these hydrazones gave the 1-aryl-6-chloro-3-(L-glycerol-1-yl)flavazoles; the mass spectrum of one of these flavazoles is discussed. Elimination of two mols of water per mol from I (R = C₆H₄Me-4, C₆H₄Br-4, C₆H₄I-4) occurred with simultaneous cyclization to give 3-[1-aryl-5-(hydroxymethyl)pyrazol-3-yl]-6-chloro-2-quinoxalinones, whose acetylation gave the corresponding monoacetyl derivatives that could also be obtained by the action of boiling Ac₂O on the starting hydrazones. Periodate oxidation of the hydrazones and the flavazole derivatives afforded the corresponding aldehydes.

Carbohydrate Research published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, COA of Formula: C7H7IN2O.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com