Month: November 2022

Bovonsombat, Pakorn published the artcileRing halogenations of polyalkylbenzenes with N-halosuccinimide and acidic catalysts, Computed Properties of 2100-25-6, the main research area is ring halogenation polyalkylbenzene; benzene halo; pyrrolidinedione halo halogenation polyalkylbenzene.

1-Bromo-2,5-pyrrolidinedione (NBS) and 1-chloro-2,5-pyrrolidinedione (NCS) with catalytic quantities of p-toluenesulfonic acid have been used for ring halogenations of polyalkylbenzenes. [Hydroxy(tosyloxy)iodo]benzene was effective as a catalyst with NBS but not NCS. Competition experiments with 1-iodo-2,5-pyrrolidinedione (NIS) were run to indicate selectivities in substrates, halogen sources and catalysts. With this information a mixed halogenated compound, 2-bromo-4-iodo-1,3,5-trimethylbenzene was prepared in high yield.

Synthesis published new progress about Halogenation. 2100-25-6 belongs to class iodides-buliding-blocks, name is 3-Iodo-1,2,4,5-tetramethylbenzene, and the molecular formula is C10H13I, Computed Properties of 2100-25-6.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Katoh, Taisuke published the artcileFacile preparation of 3-substituted-2,6-difluoropyridines: application to the synthesis of 2,3,6-trisubstituted pyridines, Application In Synthesis of 685517-67-3, the main research area is substituted pyridine preparation; halopyridine fluorination nucleophilic substitution.

We report a facile method for the difluorination of 3-substituted-2,6-dichloropyridines using cesium fluoride as a fluorination reagent in DMSO. It is proposed that this method for preparing 3-substituted-2,6-difluoropyridines is simpler and easier than those reported in previous literature. To examine the utility of 3-substituted-2,6-difluoropyridines in synthetic chem., we also demonstrate a subsequent conversion to 2,3,6-trisubstituted pyridines by a tandem nucleophilic aromatic substitution.

Tetrahedron Letters published new progress about Fluorination. 685517-67-3 belongs to class iodides-buliding-blocks, name is 2,6-Difluoro-3-iodopyridine, and the molecular formula is C5H2F2IN, Application In Synthesis of 685517-67-3.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Oshikawa, Yuji published the artcileCell Surface-Anchored Fluorescent Probe Capable of Real-Time Imaging of Single Mast Cell Degranulation Based on Histamine-Induced Coordination Displacement, COA of Formula: C6H4INO3, the main research area is cell surface fluorescence probe imaging mast degranulation histamine coordination.

Mast cells secrete histamine upon degranulation triggered by various stimuli. Herein, we report the new detection method of mast cell degranulation using the fluorescent probe capable of detection of the released histamine. The probe was designed as the Co(II) complex of a cyanine dye, which shows a turn-on fluorescence signal based on a histamine-induced coordination displacement mechanism. Fluorescence imaging using the cell surface-anchored fluorescent probe enabled the real-time detection of mast cell degranulation induced by various secretagogues.

Analytical Chemistry (Washington, DC, United States) published new progress about Fluorescence. 21784-73-6 belongs to class iodides-buliding-blocks, name is 4-Iodo-2-nitrophenol, and the molecular formula is C6H4INO3, COA of Formula: C6H4INO3.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Knipe, Peter C. published the artcileRemote conformational control of a molecular switch via methylation and deprotonation, Recommanded Product: 4-Iodo-3-nitroaniline, the main research area is arylcarboxamido benzamido phenylethynylbenzoate preparation conformation hydrogen bonding; dependence conformation arylcarboxamido benzamido phenylethynylbenzoate methylation deprotonation; mol crystal structure arylcarboxamido benzamido phenylethynylbenzoate.

(Arylcarboxamido)(benzamido)phenylethynylbenzoates I (R = H, Me; R1 = H, Me) were prepared and the changes in their conformations due to changes in the chemoselectivity of intramol. hydrogen bonding (whether the ester moiety accepts a hydrogen bond from the unsubstituted or substituted benzamide) were determined relative to compounds in which the benzamides cannot hydrogen bond or in which they are fully hydrogen-bonded. Removal of the Me groups led to increasing hydrogen bonding between the substituted benzamide and the ester moieties. Addition of base to I (R = H; R = Me) yielded a salt in which only the unsubstituted benzamide hydrogen bonded to the ester moiety because of the formation of a stronger hydrogen bond between the phenolate and the substituted benzamide. The structures of I (R = H, Me; R1 = Me) and of the tetrabutylammonium salt of monodeprotonated I (R = H; R1 = Me) were determined by X-ray crystallog., while the structure of the anion of monodeprotonated I (R = H; R1 = Me) was determined by calculation

Organic & Biomolecular Chemistry published new progress about Conformation. 105752-04-3 belongs to class iodides-buliding-blocks, name is 4-Iodo-3-nitroaniline, and the molecular formula is C6H5IN2O2, Recommanded Product: 4-Iodo-3-nitroaniline.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Jones, Ian M. published the artcileRedox-dependent conformational switching of diphenylacetylenes, COA of Formula: C6H5IN2O2, the main research area is benzamido diphenylacetylene ferrocene conformation hydrogen bond mol switch.

Herein we describe the design and synthesis of a redox-dependent single-mol. switch. Appending a ferrocene unit to a diphenylacetylene scaffold gives a redox-sensitive handle, which undergoes reversible one-electron oxidation, as demonstrated by cyclic voltammetry anal. 1H-NMR spectroscopy of the partially oxidized switch and control compounds suggests that oxidation to the ferrocenium cation induces a change in hydrogen bonding interactions that results in a conformational switch.

Molecules published new progress about Conformation. 105752-04-3 belongs to class iodides-buliding-blocks, name is 4-Iodo-3-nitroaniline, and the molecular formula is C6H5IN2O2, COA of Formula: C6H5IN2O2.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Xie, Caixia published the artcileAn efficient route for the synthesis of N-(1H-benzo[d]imidazol-2-yl)benzamide derivatives promoted by CBr4 in one pot, Name: Ethyl 3-(4-iodophenyl)-3-oxopropanoate, the main research area is benzoimidazolyl benzamide preparation.

A metal-free one-pot method for the synthesis of N-(1H-benzo[d]imidazol-2-yl)benzamide derivatives such as I [R1 = Ph, 4-MeC6H4, 1-naphthyl, etc.; R2 = Me, Et, Ph] and N-(1H-imidazol-2-yl)benzamide derivatives II [R3 = 4-ClC6H4, 4-MeOC6H4, 4-CF3C6H4, etc.; R4 = Et, Me] was proposed mediated by CBr4. The reaction went through ring formation and opening processes with only two protons leaving and the thermodynamically favorable products were selectively formed in moderate to good yields. Easily accessible starting materials, simple operations and high atom economy made this strategy a potential and useful method in organic and pharmaceutical chem.

Tetrahedron published new progress about Atom economy. 63131-30-6 belongs to class iodides-buliding-blocks, name is Ethyl 3-(4-iodophenyl)-3-oxopropanoate, and the molecular formula is C11H11IO3, Name: Ethyl 3-(4-iodophenyl)-3-oxopropanoate.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Song, Zi-Long published the artcileSynthesis of Dithiolethiones and Identification of Potential Neuroprotective Agents via Activation of Nrf2-Driven Antioxidant Enzymes, SDS of cas: 63131-30-6, the main research area is dithiolethione preparation neuroprotective antioxidant; Nrf2 activation; PC12 cells; antioxidant genes; dithiolethiones; oxidative stress.

Oxidative stress is implicated in the pathogenesis of a wide variety of neurodegenerative disorders, and accordingly, dietary supplement of exogenous antioxidants or/and upregulation of the endogenous antioxidant defense system are promising for therapeutic intervention or chemoprevention of neurodegenerative diseases. Nrf2, a master regulator of the cellular antioxidant machinery, cardinally participates in the transcription of cytoprotective genes against oxidative/electrophilic stresses. Herein, we report the synthesis of 59 structurally diverse dithiolethiones and evaluation of their neuroprotection against 6-hydroxydopamine- or H2O2-induced oxidative damages in PC12 cells, a neuron-like rat pheochromocytoma cell line. Initial screening identified compounds I (X = F, or Cl) having low cytotoxicity but conferring remarkable protection on PC12 cells from oxidative-mediated damages. Further studies demonstrated that both compounds upregulated a battery of antioxidant genes as well as corresponding genes’ products. Significantly, silence of Nrf2 expression abolishes cytoprotection of I (X = F, or Cl), indicating targeting Nrf2 activation is pivotal for their cellular functions. Taken together, the two lead compounds discovered here with potent neuroprotective functions against oxidative stress via Nrf2 activation merit further development as therapeutic or chemopreventive candidates for neurodegenerative disorders.

Journal of Agricultural and Food Chemistry published new progress about Antioxidants. 63131-30-6 belongs to class iodides-buliding-blocks, name is Ethyl 3-(4-iodophenyl)-3-oxopropanoate, and the molecular formula is C11H11IO3, SDS of cas: 63131-30-6.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Bekarek, V. published the artcileCorrelations between proton chemical shifts of hydroxyl groups with intramolecular hydrogen bondings and Hammett substituent constants, Quality Control of 21784-73-6, the main research area is hydrogen bonding intramol; proton chem shift; chem shift proton; shift chem proton; intramol H bonding; hydroxyl group chem shift; Hammett substituent constant.

The dependence of the proton chem. shifts of OH groups on Hammett σ constant is proposed in the form: τ = a + bσ1 + cσ2. bσ1 describes the substituent effect on the proton chem. shift of the OH group across the O-H bond and cσ2 the effect of substituents upon the electron donor involved in the formation of the H bonding. Three series of compounds were used to test the validity of the equation proposed, namely, 0-nitrophenols, salicylaldehydes, and 0-hydroxyazobenzenes. The values of the constant a, b, and c were calculated by the least sqs. method: 0-nitrophenols: -0.57, -1.260, +0.990; salicylaldehydes: -0.93, -1.186, +0.900; and 0-hydroxyazobenzenes: -1.21, -2.040, +2.484. A good agreement was found for substituted 0-nitrophenols. In the case of salicylaldehydes a considerable deviation was found for the 5-NO2 derivative There is an intramol. H bonding under exptl. conditions and such H bonding exists even in 0-hydroxyazobenzene for the data measured in Me2SO.

Collection of Czechoslovak Chemical Communications published new progress about Hydrogen bond. 21784-73-6 belongs to class iodides-buliding-blocks, name is 4-Iodo-2-nitrophenol, and the molecular formula is C6H4INO3, Quality Control of 21784-73-6.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Jin, Xin published the artcilePinning-down molecules in self-assemblies with multiple weak hydrogen bonds of C-H···F and C-H···N, Application In Synthesis of 685517-67-3, the main research area is mol self assembly hydrogen bond.

Two-dimensional self-assemblies of four partially fluorinated mols., 1,4-bis(2,6-difluoropyridin-4-yl)benzene, 4,4′-bis(2,6-difluoropyridin-4-yl)-1,1′-biphenyl, 4,4′-bis(2,6-difluoropyridin-4-yl)-1,1′:4′,1”-terphenyl and 4,4′-bis(2,6-difluoropyridin-3-yl)-1,1′-biphenyl, involving weak intermol. C-H···F and C-H···N hydrogen bonds were systematically investigated on Au(111) with low-temperature scanning tunneling microscopy. The inter-mol. connecting modes and binding sites were closely related to the backbones of the building blocks, i.e., the mol. length determines its binding sites with neighboring mols. in the assemblies while the attaching positions of the N and F atoms dictate its approaching and docking angles. The exptl. results demonstrate that multiple weak hydrogen bonds such as C-H···F and C-H···N can be efficiently applied to tune the mol. orientations and the self-assembly structures accordingly.

Chinese Chemical Letters published new progress about Hydrogen bond. 685517-67-3 belongs to class iodides-buliding-blocks, name is 2,6-Difluoro-3-iodopyridine, and the molecular formula is C5H2F2IN, Application In Synthesis of 685517-67-3.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Tietze, Lutz F. published the artcileStereoselective synthesis of steroids with the Heck reaction, Product Details of C10H13I, the main research area is double Heck reaction stereoselective steroid preparation.

The authors describe a new strategy, based on the synthesis of the B-ring of the steroid structure, via a double Heck reaction between (Z)-2-(2-bromoethenyl)bromobenzene and a hexahydro-1H-indene derivative This novel Pd-catalyzed annelation provides a general and efficient access to steroidal systems.

Angewandte Chemie, International Edition in English published new progress about Heck reaction. 2100-25-6 belongs to class iodides-buliding-blocks, name is 3-Iodo-1,2,4,5-tetramethylbenzene, and the molecular formula is C10H13I, Product Details of C10H13I.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com