Month: November 2022

Tu, Jia-Lin published the artcileRadical Aza-Cyclization of α-Imino-oxy Acids for Synthesis of Alkene-Containing N-Heterocycles via Dual Cobaloxime and Photoredox Catalysis, Name: Ethyl 3-(4-iodophenyl)-3-oxopropanoate, the main research area is radical aza cyclization alpha iminooxy acid; dual cobaloxime photoredox catalysis; alkene heterocycle stereoselective dihydropyrrole preparation.

Nitrogen-containing heterocycles are prevalent in both naturally and synthetically bioactive mols. We report herein an unprecedented protocol for radical aza-cyclization of α-imino-oxy acids with pendant alkenes via synergistic photoredox and cobaloxime catalysis. With or without alkenes as the intermol. cross-coupling partners, the transformation provides a variety of corresponding alkene-containing dihydropyrrole products in satisfactory yields. In the presence of external alkenes, the tandem reaction generates E-selective coupling products with excellent chemo- and stereoselectivity.

Organic Letters published new progress about Diastereoselective synthesis. 63131-30-6 belongs to class iodides-buliding-blocks, name is Ethyl 3-(4-iodophenyl)-3-oxopropanoate, and the molecular formula is C11H11IO3, Name: Ethyl 3-(4-iodophenyl)-3-oxopropanoate.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Satish, Gandhesiri published the artcileI2Cu-mediated self-sorting domino reaction of aryl β-ketoesters into symmetrical 2-carboalkoxy-1,4-enediones: application to synthesis of pyrazine, β-carboline and quinoxalines, Recommanded Product: Ethyl 3-(4-iodophenyl)-3-oxopropanoate, the main research area is enedione preparation stereoselective; ketoester domino reaction iodine copper acetate catalyst; quinoxaline carboline pyrazine preparation; diamine aryl enedione preparation nucleophilic addition iodine catalyst.

A self-sorting domino reaction of aryl β-ketoesters RC6H4C(O)CH2C(O)OCH2CH3 into sym. E:Z mixture of 1,4-enediones RC(O)C(CO2CH2CH3):CHC(O)R was reported by an I2/Cu system. The reaction proceeds through tandem iodination, self-dimerization and Krapcho dealkoxycarbonylation in one pot under open air condition. Further, E:Z mixture of 1,4-enediones RC(O)C(CO2CH2CH3):CHC(O)R were successfully employed for the synthesis of bioactive pyrazine, β-carboline and quinoxalines I via aza-Michael addition, intramol. cyclization and C-C bond cleavage of 1,3-dicarbonyl unit under mild reaction condition.

RSC Advances published new progress about Diastereoselective synthesis. 63131-30-6 belongs to class iodides-buliding-blocks, name is Ethyl 3-(4-iodophenyl)-3-oxopropanoate, and the molecular formula is C11H11IO3, Recommanded Product: Ethyl 3-(4-iodophenyl)-3-oxopropanoate.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wang, Yu-Hao published the artcileA formal [3 + 3] cycloaddition of allenyl imide and activated ketones for the synthesis of tetrasubstituted 2-pyrones, HPLC of Formula: 63131-30-6, the main research area is pyrone preparation; allenyl imide ketoester cycloaddition; diketone allenyl imide cycloaddition; ketonitrile allenyl imide cycloaddition.

CsOH.H2O-catalyzed formal [3 + 3] cycloadditions of allenyl imide with β-ketoesters RC(O)CH2C(O)OR1 (R = Ph, cyclohexyl, 2-thienyl, Me, etc.; R1 = Me, Et), 1,3-diketones R2C(O)CH2R3 [R2 = Ph, 3-fluorophenyl, 2-iodophenyl, etc; R3 = C(O)C6H5, C(O)(3-CH3C6H4), C(O)(3-(CH3O)C6H4), C(O)(3-(CF3)C6H4)] or β-ketonitriles R2C(O)CH2R3 (R3 = CN) for the synthesis of tetrasubstituted 2-pyrone derivatives I, II have been demonstrated. The allenyl imide was utilized as a C3-synthon, and a ketenyl intermediate was proposed via the process of 1,4-addition of carbon anion to allene followed by elimination of the 2-oxazolidinyl group.

RSC Advances published new progress about [3+3] Cycloaddition reaction. 63131-30-6 belongs to class iodides-buliding-blocks, name is Ethyl 3-(4-iodophenyl)-3-oxopropanoate, and the molecular formula is C11H11IO3, HPLC of Formula: 63131-30-6.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Chen, Rongxiang published the artcileIn situ generation of nitrile oxides from copper carbene and tert-butyl nitrite: synthesis of fully substituted isoxazoles, COA of Formula: C11H11IO3, the main research area is keto ester diazoacetate cycloaddition copper nitrite; isoxazole preparation; nitrile oxide in situ copper carbene nitrite.

A [3 + 2] cycloaddition reaction of β-keto esters with nitrile oxides, which were generated in situ from copper carbene and tert-Bu nitrite, is reported. This three-component reaction provides methodol. for the direct synthesis of fully substituted isoxazole derivatives, featuring mild reaction conditions, readily accessible starting materials and simple operation. The exptl. studies and DFT calculations suggest that the reaction starts with the generation of the key intermediate nitrile oxides, followed by a [3 + 2] cycloaddition reaction of β-keto esters to give the final isoxazole products.

Organic & Biomolecular Chemistry published new progress about [3+2] Cycloaddition reaction. 63131-30-6 belongs to class iodides-buliding-blocks, name is Ethyl 3-(4-iodophenyl)-3-oxopropanoate, and the molecular formula is C11H11IO3, COA of Formula: C11H11IO3.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Orlov, V. Yu. published the artcileEffect of the electronic structure of the radical anions of 4-substituted 1,2- and 1,3-dinitrobenzenes on the regioselectivity of reduction of the nitro groups, Name: 4-Iodo-3-nitroaniline, the main research area is selective reduction dinitrobenzene regioselectivity nitro group.

Theor. and exptl. regularities of the regioselectivity of the reduction of one of the two nitro groups in unsym. dinitrobenzenes were studied. It was found that the regioselectivity of the formation of isomeric nitroanilines depends on the structure of the substrate and the nature of the reducing agent. The reduction regioselectivity model was verified, according to which radical anion protonation is the major reaction direction.

Russian Journal of General Chemistry published new progress about AM1 (molecular orbital method). 105752-04-3 belongs to class iodides-buliding-blocks, name is 4-Iodo-3-nitroaniline, and the molecular formula is C6H5IN2O2, Name: 4-Iodo-3-nitroaniline.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Gundoju, Narayanarao published the artcileBetulinic acid derivatives: a new class of α-glucosidase inhibitors and LPS-stimulated nitric oxide production inhibition on mouse macrophage RAW 264.7 cells, Name: 4-Iodo-3-nitroaniline, the main research area is betulinic acid alpha glucosidase inhibitor; LPS-stimulated nitric oxide production inhibition; betulinic acid; α-glucosidase inhibition.

Chem. manipulation studies were conducted on betulinic acid, twenty-one new rationally designed analogs of betulinic acid with modifications at C-28 were synthesized for their evaluation of inhibitory effects on α-glucosidase and LPS-stimulated nitric oxide production in mouse macrophage RAW 264.7 cells. 2-Oxo-2-morpholinoethyl 3β-hydroxylup-20(29)-en-28-oate (2; IC50 = 5.4 μM) exhibited an almost 1.4-fold increase in α-glucosidase inhibitory activity on yeast α-glucosidase while analogs (IC50 16.4 μM) and (IC50 16.6 μM) exhibited a 2-fold enhanced inhibitory activity on NO-production than betulinic acid.

Natural Product Research published new progress about Structure-activity relationship. 105752-04-3 belongs to class iodides-buliding-blocks, name is 4-Iodo-3-nitroaniline, and the molecular formula is C6H5IN2O2, Name: 4-Iodo-3-nitroaniline.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Hutton, Harold M. published the artcileDetermination of substituent effects by factor analysis and multiple linear regression for the carbon-13 nuclear magnetic resonance chemical shifts in 4-substituted phenols and 2-nitrophenols, Product Details of C6H4INO3, the main research area is LFER NMR phenol derivative.

13C NMR chem. shifts are reported for a series of 4-substituted phenols and 2-nitrophenols in Me2SO. For chem. shift correlations, it was found by factor anal. and iterative multiple linear regression that the para chem. shifts require two substituent factors whereas the ipso, ortho, and meta chem. shifts require 3 factors. Regression analyses were performed using the field and resonance parameters (σF, σR0) and the appropriate ipso, ortho, and meta parameters determined by Reynolds. Good correlations were obtained except for the 3 meta carbon analyses, where the correlation coefficients range from 0.877 to 0.963.

Canadian Journal of Chemistry published new progress about Linear free energy relationship. 21784-73-6 belongs to class iodides-buliding-blocks, name is 4-Iodo-2-nitrophenol, and the molecular formula is C6H4INO3, Product Details of C6H4INO3.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Chen, Qiwei published the artcileSteering On-Surface Reactions by a Self-Assembly Approach, SDS of cas: 685517-67-3, the main research area is on surface synthesis functional nanostructure preparation; difluoropyridnyl terphenyl self assembly mediated reaction gold surface; scanning tunneling microscopy assessment self assembly reaction gold surface; density functional theory calculation self assembly reaction gold surface; self assembly reaction gold surface scanning tunneling microscopy; dehydrocyclization coupling reaction difluoropyridnyl terphenyl gold surface; dehydrocyclization; density functional theory; on-surface reaction; scanning tunneling microscope; self-assembly.

4,4′-Bis(2,6-difluoropyridin-4-yl)-1,1′:4′,1”-terphenyl (BDFPTP) mols. underwent dehydrocyclization and covalent coupling reactions on Au(111) according to scanning tunneling microscopy measurements and d. functional theory calculations Self-assembly of the reactants in well-defined mol. domains prior to reaction greatly enhances the regio-selectivity of the dehydrocyclization reaction and suppressed defluorinated coupling, demonstrating that self-assembly can efficiently steer on-surface reactions. Such a strategy could be greatly important for surface chem. and widely used to control on-surface reactions.

Angewandte Chemie, International Edition published new progress about Coupling reaction (defluorinated). 685517-67-3 belongs to class iodides-buliding-blocks, name is 2,6-Difluoro-3-iodopyridine, and the molecular formula is C5H2F2IN, SDS of cas: 685517-67-3.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Jiang, Xiang-Rong published the artcileSynthesis of Novel Estrogen Receptor Antagonists Using Metal-Catalyzed Coupling Reactions and Characterization of Their Biological Activity, Formula: C11H11IO3, the main research area is estrogen receptor antagonist preparation metal catalyzed coupling antitumor.

Estrogen receptor (ER) antagonists are valuable in the treatment of ER-pos. human breast cancer. In this study, we designed and synthesized nine new derivatives of 17β-estradiol (E2) with a bulky side chain attached to its C-7α position, and determined their ER antagonistic activity using in vitro bioassays. Four of the derivatives showed a strong inhibition of ERα transactivation activity in a luciferase reporter assay and blocked ERα interactions with coactivators. Similarly, these derivatives also strongly inhibited the growth of the ERα-pos. human breast cancer cells. Computational docking anal. was conducted to model the interaction of these antagonists with the human ERα and showed that they could tightly bind to the ERα in a manner similar to that of ICI-182,780, a pure ER antagonist. These results provide an example that attachment of a bulky side chain to the C-7α position of E2 can produce ER antagonists with ER affinity comparable to that of ICI-182,780.

Journal of Medicinal Chemistry published new progress about 1,3-Dipolar cycloaddition reaction. 63131-30-6 belongs to class iodides-buliding-blocks, name is Ethyl 3-(4-iodophenyl)-3-oxopropanoate, and the molecular formula is C11H11IO3, Formula: C11H11IO3.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Tsuda, Susumu published the artcileSynthesis of linked symmetrical [3] and [5]rotaxanes having an oligomeric phenylene ethynylene (OPE) core skeleton as a π-conjugated guest via double intramolecular self-inclusion, Category: iodides-buliding-blocks, the main research area is rotaxane oligomeric phenylene ethynylene cyclodextrin preparation absorption emission photoluminescence; inclusion Huisgen cycloaddition Sonogashira coupling.

Linked sym. [3] and [5]rotaxanes consisting of an oligomeric phenylene ethynylene (OPE) framework as a π-conjugated guest moiety and lipophilic permethylated α-cyclodextrins (PM α-CDs), as macrocyclic hosts have been prepared by double intramol. self-inclusion of an OPE guest unit carrying two PM α-CDs followed by capping with bulky stopper groups using click azide-alkyne Huisgen cycloaddition or Sonogashira coupling. The structures of these linked rotaxanes were determined by MALDI-TOF mass spectrum and two-dimensional NMR spectroscopy.

Tetrahedron Letters published new progress about 1,3-Dipolar cycloaddition reaction. 2100-25-6 belongs to class iodides-buliding-blocks, name is 3-Iodo-1,2,4,5-tetramethylbenzene, and the molecular formula is C10H13I, Category: iodides-buliding-blocks.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com