Month: November 2022

Suzuki, Hitomi published the artcileThe reaction of polysubstituted aromatics. LVI. The copper(I) iodide-assisted reaction of nonactivated aryl iodides with some alkali metal pseudohalides, Formula: C10H13I, the main research area is aryl iodide substitution pseudohalide; azide substitution polymethylaryl iodide; selenocyanate substitution polymethylaryl iodide; tellurocyanate reaction polymethylaryl iodide; cyanide reaction polymethylaryl iodide; cyanide aryl.

CuI dissolves in warm (O)P(NMe2)3 to give a black solution in which polymethylated iodobenzenes undergo nucleophilic attack by azide and selenocyanate ions, giving the corresponding aryl azides and selenocyanates in low to good yields. In the absence of Cu(I) salt, however, the reaction does not take place. Cyanide, cyanate, thiocyanate, and fluoride ions cause a decoloration of the reaction mixture and no displacement reactions ensue, while the tellurocyanate ion gives the corresponding aryl cyanides while liberating elemental Te.

Bulletin of the Chemical Society of Japan published new progress about Aryl iodides Role: RCT (Reactant), RACT (Reactant or Reagent). 2100-25-6 belongs to class iodides-buliding-blocks, name is 3-Iodo-1,2,4,5-tetramethylbenzene, and the molecular formula is C10H13I, Formula: C10H13I.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Xiao, Li-Jun published the artcilePdII-Catalyzed Enantioselective C(sp3)-H Arylation of Cyclobutyl Ketones Using a Chiral Transient Directing Group, COA of Formula: C5H2F2IN, the main research area is arylcyclobutyl ketone regioselective diastereoselective enantioselective preparation; palladium catalyst stereoselective arylation cyclobutyl ketone transient directing group; C−H activation; arylation; palladium; pyridone ligands; transient directing groups.

In the presence of Pd(OAc)2, 3-nitro-5-trifluoromethyl-2-pyridone, and D-valine as a transient directing group reagent, cyclobutyl ketones such as I (R = H) underwent regioselective, diastereoselective, and enantioselective arylation with aryl iodides R1I (R1 = 4-MeO2CC6H4, 4-O2NC6H4, 4-MeCOC6H4, 4-NCC6H4, 4-F3CC6H4, 3-O2NC6H4, 3-PhCOC6H4, 3,4,5-F3C6H2, 3,5-Br2C6H3, 3-Br-5-ClC6H3, 4-Me-3-O2NC6H3, 2-Br-5-FC6H3, 6-F-3-pyridinyl, 2-F3C-4-pyridinyl, 6-Cl-5-F3C-3-pyridinyl, 6-Br-3-pyridinyl, 2,6-F2-4-pyridinyl, 2,6-F2-3-pyridinyl, 2,6-Cl2-4-pyridinyl, 5-acetyl-2-thienyl) to yield arylcyclobutyl ketones such as I (R = 4-MeO2CC6H4, 4-O2NC6H4, 4-MeCOC6H4, 4-NCC6H4, 4-F3CC6H4, 3-O2NC6H4, 3-PhCOC6H4, 3,4,5-F3C6H2, 3,5-Br2C6H3, 3-Br-5-ClC6H3, 4-Me-3-O2NC6H3, 2-Br-5-FC6H3, 6-F-3-pyridinyl, 2-F3C-4-pyridinyl, 6-Cl-5-F3C-3-pyridinyl, 6-Br-3-pyridinyl, 2,6-F2-4-pyridinyl, 2,6-F2-3-pyridinyl, 2,6-Cl2-4-pyridinyl, 5-acetyl-2-thienyl). In the presence of either L-valine as a transient directing group reagent or when silver trifluoroacetate, acetate, carbonate, or oxide were used as bases, enantiomeric arylcyclobutyl ketones were formed. A sequential diarylation was performed to yield diastereomeric diarylcyclobutyl ketones enantioselectively.

Angewandte Chemie, International Edition published new progress about Aryl iodides Role: RCT (Reactant), RACT (Reactant or Reagent). 685517-67-3 belongs to class iodides-buliding-blocks, name is 2,6-Difluoro-3-iodopyridine, and the molecular formula is C5H2F2IN, COA of Formula: C5H2F2IN.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Obeid, Naim M. published the artcile(Oligo)aromatic species with one or two conjugated Si:Si bonds: near-IR emission of anthracenyl-bridged tetrasiladiene, Product Details of C10H13I, the main research area is disilene preparation crystal structure DFT calculation fluorescence; tetrasiladiene paraarylene bridged preparation crystal structure DFT calculation fluorescence; crystal structure disilene paraarylene bridged tetrasiladiene; mol structure disilene paraarylene bridged tetrasiladiene.

Aryl disilenes Tip2Si:Si(Tip)Ar (2a-d) and para-arylene bridged tetrasiladienes, Tip2Si:Si(Tip)-LU-Si(Tip):SiTip2 (3a-d) were synthesized by the transfer of the Tip2Si:SiTip unit to aryl halides and dihalides by nucleophilic disilenides Tip2Si:SiTipLi (Tip = 2,4,6-iPr3C6H2, Ar = aryl substituent, LU = para-arylene linking unit). The scope of the nucleophilic Si:Si transfer reaction is demonstrated to also include substrates of considerable steric bulk such as mesityl or duryl halides Ar-X (Ar = Mes = 2,4,6-Me3C6H2; Ar = Dur = 2,3,5,6-Me4C6H, X = Br or I). Bridged tetrasiladienes Tip2Si:Si(Tip)-LU-Si(Tip):SiTip2 with more extended linking units surprisingly exhibit fluorescence at room temperature, albeit weak. DFT calculations suggest that partial charge transfer character of the excited state is a possible explanation.

Dalton Transactions published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 2100-25-6 belongs to class iodides-buliding-blocks, name is 3-Iodo-1,2,4,5-tetramethylbenzene, and the molecular formula is C10H13I, Product Details of C10H13I.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Scheipers, Ina published the artcilePalladium-Catalyzed Decarboxylative γ-Arylation for the Synthesis of Tetrasubstituted Chiral Allenes, Synthetic Route of 2100-25-6, the main research area is alkynoic acid aryl iodide enantioselective palladium catalyst decarboxylative arylation; chiral tetrasubstituted allene stereoselective preparation; allenes; asymmetric synthesis; chirality transfer; cross-coupling; palladium.

An enantiospecific palladium-catalyzed decarboxylative coupling of acyclic β,γ-alkynoic acids with various aryl iodides to chiral tetrasubstituted allenes is described. The coupling reaction comprises a decarboxylative γ-palladation of α,α-disubstituted carboxylic acids to provide the tetrasubstituted allenes with complete point-to-axial chirality transfer in excellent yields.

Angewandte Chemie, International Edition published new progress about Allenes Role: SPN (Synthetic Preparation), PREP (Preparation). 2100-25-6 belongs to class iodides-buliding-blocks, name is 3-Iodo-1,2,4,5-tetramethylbenzene, and the molecular formula is C10H13I, Synthetic Route of 2100-25-6.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Lu, Xiao-Yu published the artcileTrisubstituted olefin synthesis via Ni-catalyzed hydroalkylation of internal alkynes with non-activated alkyl halides, Formula: C11H12INO2, the main research area is alkene preparation stereoselective regioselective; internal alkyne alkyl halide nickel catalyst hydroalkylation.

Ni-catalyzed regio- and stereo-selective hydroalkylation of internal alkynes R1CCR2 [R1 = Ph, pyridin-3-yl, (CH2)2CH3, etc.; R2 = Me, Ph, (CH2)3CH3, etc.] with non-activated alkyl halides XR3 (R3 = cyclohexyl, butan-2-yl, 1-[(4-methylbenzene)sulfonyl]pyrrolidin-3-yl, etc.; X = I, Br) was reported. This method does not use any sensitive organometallic reagents and shows good functional group compatibility, which enables the efficient synthesis of many tri-substituted olefins R1CH=C(R2)(R3) from readily available coupling partners. It also provides a straightforward method for the modification of bioactive organic mols.

Chemical Communications (Cambridge, United Kingdom) published new progress about Alkenes Role: SPN (Synthetic Preparation), PREP (Preparation). 939759-26-9 belongs to class iodides-buliding-blocks, name is Benzyl 3-iodoazetidine-1-carboxylate, and the molecular formula is C11H12INO2, Formula: C11H12INO2.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wei, Jiao Jiao published the artcileN,N-dimethyl-D-glucosamine as an efficient ligand for copper-catalyzed Ullmann-type coupling of N-H heterocycles with aryl halides, Recommanded Product: Ethyl 3-(4-iodophenyl)-3-oxopropanoate, the main research area is nitrogen heterocycle halobenzene glucosamine copper catalyst Ullmann coupling; arylated nitrogen heterocycle preparation green chem.

A new N,N-dimethyl-D-glucosamine ligand was developed for the copper-catalyzed Ullmann-type coupling of N-H heterocycles (e.g., indoles, benzimidazoles, pyrazoles and triazoles) with aryl halides. This method was accomplished not only featuring excellent yields, mild reaction conditions and simple operation, but also showing eco-friendly and broad-spectrum substrates and could be widely used in the construction of N-aryl heterocyclic systems.

Tetrahedron published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 63131-30-6 belongs to class iodides-buliding-blocks, name is Ethyl 3-(4-iodophenyl)-3-oxopropanoate, and the molecular formula is C11H11IO3, Recommanded Product: Ethyl 3-(4-iodophenyl)-3-oxopropanoate.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Awad, Hacan published the artcileDeprotonation of fluoro aromatics using lithium magnesates, Recommanded Product: 2,6-Difluoro-3-iodopyridine, the main research area is deprotonation fluoro aromatic lithium magnesate.

3-Fluoropyridine was deprotonated on treatment with 1/3 equiv of Bu3MgLi in THF at -10 °C. The lithium arylmagnesate formed was either trapped with electrophiles or involved in a palladium-catalyzed cross-coupling reaction with 2-bromopyridine. The use of a less nucleophilic lithium-magnesium-dialkylamide, (TMP)3MgLi (TMP = 2,2,6,6-tetramethylpiperidino) allowed the reaction of 3-fluoroquinoline, giving the 2,2′-dimeric derivative 2-Fluoropyridine and 2,6-difluoropyridine were deprotonated using 1/3 equiv of the highly coordinated magnesate Bu4MgLi2 in THF at -10 °C in the presence of a substoichiometric amount of 2,2,6,6-tetramethylpiperidine. 1,3-Difluorobenzene reacted similarly when treated with Bu3MgLi; the reactivity of the base proved to be enhanced by the presence of TMEDA.

Tetrahedron Letters published new progress about Aryl fluorides Role: RCT (Reactant), RACT (Reactant or Reagent). 685517-67-3 belongs to class iodides-buliding-blocks, name is 2,6-Difluoro-3-iodopyridine, and the molecular formula is C5H2F2IN, Recommanded Product: 2,6-Difluoro-3-iodopyridine.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Sumi Mitra, S. published the artcilePolymer-bound benzyltriethylammonium polyhalides: recyclable reagents for the selective iodination of amines and phenols, Formula: C6H5IN2O2, the main research area is polymer bound benzyltriethylammonium halide iodination agent; phenol iodination polymer bound benzyltriethylammonium halide; amine iodination polymer bound benzyltriethylammonium halide.

Polymer-bound benzyltriethylammonium dichloroiodate, tetrachloroiodate, and dibromoiodate reagents were developed as new recyclable solid-phase reagents. The use of these polymeric polyhalides for the iodination of activated benzene and naphthalene derivatives such as amines and phenols is described. The spent reagents after the synthetic reactions were easily removed by filtration and were regenerated for further use. The efficiency of these reagents towards mono-selectivity in aromatic iodination and the variation of reactivity of the iodinating reagents as a function of the nature of solvent, effective molar concentration and temperature were investigated.

Reactive & Functional Polymers published new progress about Aromatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 105752-04-3 belongs to class iodides-buliding-blocks, name is 4-Iodo-3-nitroaniline, and the molecular formula is C6H5IN2O2, Formula: C6H5IN2O2.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Muathen, Hussni A. published the artcileMild and efficient iodination of aromatic compounds with pyridine-iodine monochloride complex (PylCl), Application of 4-Iodo-2-nitrophenol, the main research area is aromatic hydrocarbon iodination; benzene iodination pyridine iodine monochloride complex.

A wide range of aromatic compounds (e.g., C6H6) have been effectively iodinated with a pyridine-iodine monochloride complex (I). Condensed polycyclic iodides, which are not readily obtained via direct iodination, can be prepared indirectly via their corresponding organomercurials in 1 step. Some benzoid and nonbenzoid heterocycles (e.g., indole) are iodinated with I.

Journal of Chemical Research, Synopses published new progress about Aromatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 21784-73-6 belongs to class iodides-buliding-blocks, name is 4-Iodo-2-nitrophenol, and the molecular formula is C6H4INO3, Application of 4-Iodo-2-nitrophenol.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Yang, Han published the artcileSynthesis of 2-Aryl Azetidines through Pd-Catalyzed Migration/Coupling of 3-Iodoazetidines and Aryl Boronic Acids, Application In Synthesis of 939759-26-9, the main research area is aryl azetidine preparation regioselective; iodoazetidine boronic acid migration cross coupling reaction palladium.

A palladium-catalyzed cross-coupling of 3-iodoazetidines and nonheteroaryl boronic acids was reported. The [1,1′-biphenyl]-2-yldicyclohexylphosphane ligand enabled the reaction that favored the formation of 2-aryl azetidines. The control experiments indicated that the reaction can proceed through either a palladium-hydride/dihydroazete complex or free dihydroazete intermediate followed by hydropalladation.

Organic Letters published new progress about Arylboronic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 939759-26-9 belongs to class iodides-buliding-blocks, name is Benzyl 3-iodoazetidine-1-carboxylate, and the molecular formula is C11H12INO2, Application In Synthesis of 939759-26-9.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com