Month: November 2022

Palav, Amey published the artcileNCBSI/KI: A Reagent System for Iodination of Aromatics through In Situ Generation of I-Cl, Safety of 4-Iodo-2-nitrophenol, the main research area is arene chlorophenylsulfonyl benzenesulfonamide potassium iodide iodination green chem; iodoarene preparation.

In-situ iodine monochloride (I-Cl) generation followed by iodination of aromatics using NCBSI/KI system was developed. The NCBSI reagent required no activation due to longer bond length, lower bond dissociation energy, and higher absolute charge d. on nitrogen. The system was adequate for mono- and diiodination of a wide range of moderate to highly activated arenes with good yield and purity. Moreover, the precursor N-(benzenesulfonyl)benzenesulfonamide was recovered and transformed to NCBSI and made the protocol eco-friendly and cost-effective.

Journal of Organic Chemistry published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 21784-73-6 belongs to class iodides-buliding-blocks, name is 4-Iodo-2-nitrophenol, and the molecular formula is C6H4INO3, Safety of 4-Iodo-2-nitrophenol.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Yusubov, Mekhman S. published the artcileSolvent-free iodination of arenes using iodine-silver nitrate combination, Synthetic Route of 2100-25-6, the main research area is arene iodination iodine silver nitrate reagent solvent free; aryl iodide preparation.

A simple and environmentally safe general method of iodination of aromatic substrates under solvent-free conditions using the I2/AgNO3 combination in a solid state is reported. Both activated and deactivated aromatic compounds afford the resp. aryl iodides in generally high yields (80-90%).

Synthetic Communications published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 2100-25-6 belongs to class iodides-buliding-blocks, name is 3-Iodo-1,2,4,5-tetramethylbenzene, and the molecular formula is C10H13I, Synthetic Route of 2100-25-6.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Kahandal, Sandeep S. published the artcileGreener iodination of arenes using sulphated ceria-zirconia catalysts in polyethylene glycol, Safety of 4-Iodo-3-nitroaniline, the main research area is sulfated ceria zirconia catalyst polyethylene glycol arene iodination.

An environmentally benign method for the selective monoiodination of diverse aromatic compounds has been developed using reusable sulfated ceria-zirconia under mild conditions. The protocol provides moderate to good yields and selectively introduces iodine at the para/ortho position in monosubstituted arenes. SO42-/Ce0.07Zr0.93O2 was found to be the best choice for the synthesis of aryl iodides in high yield, presumably due to the maximum number of acid sites (4.23 mmol g-1) among the various compositions of the catalyst system.

RSC Advances published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 105752-04-3 belongs to class iodides-buliding-blocks, name is 4-Iodo-3-nitroaniline, and the molecular formula is C6H5IN2O2, Safety of 4-Iodo-3-nitroaniline.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Cheung, Chi Wai published the artcileMild and Phosphine-Free Iron-Catalyzed Cross-Coupling of Nonactivated Secondary Alkyl Halides with Alkynyl Grignard Reagents, Computed Properties of 939759-26-9, the main research area is secondary alkyl halide alkynyl Grignard iron cross coupling catalyst; alkyne substituted preparation.

A simple protocol for iron-catalyzed cross-coupling of nonactivated secondary alkyl bromides and iodides with alkynyl Grignard reagents at room temperature has been developed. A wide range of secondary alkyl halides and terminal alkynes are tolerated to afford the substituted alkynes in good yields. A slight modification of the reaction protocol also allows for cross-coupling with a variety of primary alkyl halides.

Organic Letters published new progress about Alkynes, internal Role: SPN (Synthetic Preparation), PREP (Preparation). 939759-26-9 belongs to class iodides-buliding-blocks, name is Benzyl 3-iodoazetidine-1-carboxylate, and the molecular formula is C11H12INO2, Computed Properties of 939759-26-9.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Li, Tao published the artcileThree-Component Minisci Reaction with 1,3-Dicarbonyl Compounds Induced by Visible Light, Synthetic Route of 63131-30-6, the main research area is quinoline preparation visible light Minisci dicarbonyl vinyl ether heterocycle; isoquinoline preparation visible light Minisci dicarbonyl vinyl ether heterocycle.

A three-component Minisci reaction coupling of 1,3-dicarbonyl compounds with vinyl ethers and quinolines or isoquinolines under visible light is developed. The 1,3-dicarbonyl compound undergoes single-electron oxidation to afford an electrophilic 1,3-dicarbonyl radical under visible light irradiation Due to the polarity of the free radical, the electrophilic radical adds to the electron-rich olefin to afford the nucleophilic radical. It coupled with the heteroarene to afford the three-component coupling products.

Organic Letters published new progress about 1,3-Dicarbonyl compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 63131-30-6 belongs to class iodides-buliding-blocks, name is Ethyl 3-(4-iodophenyl)-3-oxopropanoate, and the molecular formula is C11H11IO3, Synthetic Route of 63131-30-6.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ton, Thi My Uyen published the artcileCopper(II) triflate catalyzed amination and aziridination of 2-alkyl substituted 1,3-dicarbonyl compounds, Synthetic Route of 63131-30-6, the main research area is aziridine preparation; aminomethyl dicarbonyl compound preparation; alkyl dicarbonyl compound aziridination amination copper triflate catalyst.

A method to prepare α-acyl-β-amino acid and 2,2-diacyl aziridine derivatives efficiently from Cu(OTf)2 + 1,10-phenanthroline (1,10-phen)-catalyzed amination and aziridination of 2-alkyl substituted 1,3-dicarbonyl compounds with PhI=NTs is described. By taking advantage of the orthogonal modes of reactivity of the substrate through slight modification of the reaction conditions, a divergence in product selectivity was observed In the presence of 1.2 equiv of the iminoiodane, amination of the allylic C-H bond of the enolic form of the substrate, formed in situ through coordination to the Lewis acidic metal catalyst, was found to selectively occur and give the β-aminated adduct. On the other hand, increasing the amount of the nitrogen source from 1.2 to 2-3 equiv was discovered to result in preferential formal aziridination of the C-C bond of the 2-alkyl substituent of the starting material and formation of the aziridine product.

Journal of the American Chemical Society published new progress about 1,3-Dicarbonyl compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 63131-30-6 belongs to class iodides-buliding-blocks, name is Ethyl 3-(4-iodophenyl)-3-oxopropanoate, and the molecular formula is C11H11IO3, Synthetic Route of 63131-30-6.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Sandzhieva, M. A. published the artcileOxidation of Iodo- and Bromo-Substituted Polymethylbenzenes in the System PbO2-CF3COOH-CH2Cl2, Application In Synthesis of 2100-25-6, the main research area is iodo bromo polymethylbenzene oxidation lead oxide trifluoroacetic acid dichloromethane.

The oxidation of mono- and diiodo- and -bromo-substituted polymethylbenzenes (mesitylene and durene) in the system PbO2-CF3COOH-CH2Cl2 at room temperature (2-70 h) leads mainly to the formation of iodo- and bromobenzyl alcs. as result of oxidation of Me group. The reaction involves intermediate formation of haloarene radical cations. ESR study of these radical cations made it possible to determine the structure of their singly occupied MOs a2 or b1 and interpret their reactivity.

Russian Journal of Organic Chemistry published new progress about Benzenoid aromatic compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 2100-25-6 belongs to class iodides-buliding-blocks, name is 3-Iodo-1,2,4,5-tetramethylbenzene, and the molecular formula is C10H13I, Application In Synthesis of 2100-25-6.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Juarez-Ornelas, Kevin A. published the artcileIodine(III)-Catalyzed Electrophilic Nitration of Phenols via Non-Bronsted Acidic NO2+ Generation, Recommanded Product: 4-Iodo-2-nitrophenol, the main research area is nitrophenol preparation iodine catalyzed electrophilic nitration phenol.

The first catalytic procedure for the electrophilic nitration of phenols was developed using iodosylbenzene as an organocatalyst based on iodine(III) and aluminum nitrate as a nitro group source. This atom-economic protocol occurs under mild, non-Bronsted acidic and open-flask reaction conditions with a broad functional-group tolerance including several heterocycles. D. functional theory (DFT) calculations at the (SMD:MeCN)Mo8-HX/(LANLo8+f,6-311+G*) level indicated that the reaction proceeds through a cationic pathway that efficiently generates the NO2+ ion, which is the nitrating species under neutral conditions.

Organic Letters published new progress about Aromatic nitro compounds Role: SPN (Synthetic Preparation), PREP (Preparation). 21784-73-6 belongs to class iodides-buliding-blocks, name is 4-Iodo-2-nitrophenol, and the molecular formula is C6H4INO3, Recommanded Product: 4-Iodo-2-nitrophenol.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhang, Dacheng published the artcileEnantio-Relay Catalysis Constructs Chiral Biaryl Alcohols over Cascade Suzuki Cross-Coupling-Asymmetric Transfer Hydrogenation, Application of Ethyl 3-(4-iodophenyl)-3-oxopropanoate, the main research area is chiral biaryl alc green preparation cascade enantio relay catalysis; haloacetophenone arylboronic acid Suzuki cross coupling asym transfer hydrogenation.

The use of an imidazolium-based organopalladium-functionalized organic-inorganic hybrid silica and ethylene-coated chiral organoruthenium-functionalized magnetic nanoparticles to catalyze a cascade Suzuki cross-coupling-asym. transfer hydrogenation reaction to prepare chiral biaryl alcs. in a two-step, one-pot process is reported. As expected, the site-isolated active species, salient imidazolium phase-transfer character and high ethylene-coated hydrophobicity can synergistically boost the catalytic performance. Furthermore, enantio-relay catalysis has the potential to efficiently prepare a variety of chiral biaryl alcs. This synthetic strategy is a general method that shows the potential of developing enantio-relay catalysis towards environmentally benign and sustainable organic synthesis.

Scientific Reports published new progress about Alcohols, chiral Role: SPN (Synthetic Preparation), PREP (Preparation) (biaryl). 63131-30-6 belongs to class iodides-buliding-blocks, name is Ethyl 3-(4-iodophenyl)-3-oxopropanoate, and the molecular formula is C11H11IO3, Application of Ethyl 3-(4-iodophenyl)-3-oxopropanoate.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wang, Lei published the artcileModification of the aminopyridine unit of 2′-deoxyaminopyridinyl-pseudocytidine allowing triplex formation at CG interruptions in homopurine sequences, Quality Control of 25391-56-4, the main research area is aminopyridine derive sequence synthesis CG inversion site.

The antigene strategy based on site-specific recognition of duplex DNA by triplex DNA formation has been exploited in a wide range of biol. activities. However, specific triplex formation is mostly restricted to homo-purine strands within the target duplex DNA, due to the destabilizing effect of CG and TA inversion sites where there is an absence of natural nucleotides that can recognize the CG and TA base pairs. Hence, the design of artificial nucleosides, which can selectively recognize these inversion sites with high affinity, should be of great significance. Recently, we determined that 2-amino-3-methylpyridinyl pseudo-dC (3MeAP-VdC) possessed significant affinity and selectivity toward a CG inversion site and showed effective inhibition of gene expression. We now describe the design and synthesis of new modified aminopyridine derivatives by focusing on small chem. modification of the aminopyridine unit to tune and enhance the selectivity and affinity toward CG inversion sites. Remarkably, we have newly found that 2-amino-4-methoxypyridinyl pseudo-dC (4OMeAP-VdC) could selectively recognize the CG base pair in all four adjacent base pairs and form a stable triplex structure against the promoter sequence of the human gene including multiple CG inversion sites.

Nucleic Acids Research published new progress about Aminopyridines Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 25391-56-4 belongs to class iodides-buliding-blocks, name is 3-Iodo-5-nitropyridin-2-amine, and the molecular formula is C5H4IN3O2, Quality Control of 25391-56-4.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com