Month: November 2022

Sun, Zhenhua published the artcileSyntheses of Pyridine C-Nucleosides as Analogues of the Natural Nucleosides dC and dU, Safety of 6-Fluoro-5-iodopyridin-2-ol, the main research area is hydrogen bond pyridine nucleoside synthesis palladium catalyst coupling; pyridine C nucleoside synthesis Heck palladium catalyst coupling.

The syntheses of four pyrimidine C-nucleosides are described. These derivatives are designed as mimics of dC and dU, and in that respect, each can form two hydrogen bonds with complementary dG or dA residues. The minor groove O2 carbonyl in each derivative is replaced by a fluorine or a Me group. The key carbon-carbon bond connecting the heterocycle to the carbohydrate is formed using a Heck-type palladium-mediated coupling reaction.

Journal of Organic Chemistry published new progress about Coupling reaction. 884660-48-4 belongs to class iodides-buliding-blocks, name is 6-Fluoro-5-iodopyridin-2-ol, and the molecular formula is C5H3FINO, Safety of 6-Fluoro-5-iodopyridin-2-ol.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wang, Liu-Gang published the artcileThieme chemistry journal awardees – where are they now? Synthesis of p-phenylene ethynylene based macrocycles and bimacrocycle through formation of the imine bond, Recommanded Product: 4-Iodo-2-nitrophenol, the main research area is aryl amine aromatic aldehyde imination macrocyclization; macrocyclic phenylene ethynylene imine preparation.

The synthesis of 3 monomacrocycles and 1 bimacrocycle from 2 para-phenylene ethynylene frameworks was described. For 2 of the monomacrocycles, the 2 frameworks were linked by an amide unit, and the macrocyclization involved the intramol. formation of 1 imine bond. For another monomacrocycle and the bimacrocycle, the frameworks contained 2 and 3 NH2 or CHO units, resp., and the macrocyclization involved the intermol. formation of 2 and 3 imine bonds, resp..

Synlett published new progress about Aromatic hydrocarbons, aryl alkynes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 21784-73-6 belongs to class iodides-buliding-blocks, name is 4-Iodo-2-nitrophenol, and the molecular formula is C6H4INO3, Recommanded Product: 4-Iodo-2-nitrophenol.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Mitra, Sudha Sumi published the artcilePolyhalide derivatives of poly[N-(2-aminoethyl)acrylamido]triethylammonium resins as iodinating reagents, Application In Synthesis of 105752-04-3, the main research area is polyacrylamide ammonium polyhalide iodinating reagent preparation; aryl amine iodination polyacrylamide ammonium polyhalide; phenol iodination polyacrylamide ammonium polyhalide; regioselective iodinating reagent aromatic amine phenol; iodo arene preparation.

Poly[N-(2-aminoethyl)acrylamido]triethylammonium dichloroiodate, tetrachloroiodate, and dibromoiodate resins are useful for selective iodination of aromatic amines and phenols. The influence of the various reaction parameters including nature of the solvent, effective molar concentration of the reagent, and temperature were investigated to find out optimum reaction conditions for achieving selectivity for monoiodination.

Macromolecular Chemistry and Physics published new progress about Aryl halides Role: SPN (Synthetic Preparation), PREP (Preparation). 105752-04-3 belongs to class iodides-buliding-blocks, name is 4-Iodo-3-nitroaniline, and the molecular formula is C6H5IN2O2, Application In Synthesis of 105752-04-3.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Patil, Arvind M. published the artcile2-methoxyethanol, a remarkably efficient and alternative reaction medium for iodination of reactive aromatics using iodine and iodic acid, SDS of cas: 105752-04-3, the main research area is aromatic iodination iodine iodic acid methoxyethanol; aryl iodide preparation solvent effect green chem.

Remarkably effective iodination of reactive aromatics carried out using iodine and iodic acid in 2-methoxyethanol as an efficient and alternative reaction medium. The comparison was made by carrying out iodination reaction in acetic acid and ethanol. The 2-methoxyethanol is excellent reaction solvent in terms of clean reaction conditions, short reaction time giving quant. yields of product and no need of further purification

Orbital: The Electronic Journal of Chemistry published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 105752-04-3 belongs to class iodides-buliding-blocks, name is 4-Iodo-3-nitroaniline, and the molecular formula is C6H5IN2O2, SDS of cas: 105752-04-3.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Shinde, Avinash T. published the artcileA practical iodination of aromatic compounds by using iodine and iodic acid, Recommanded Product: 4-Iodo-3-nitroaniline, the main research area is aromatic iodination iodine iodic acid; aryl iodide preparation.

This article described simple and efficient method for the iodination of different aromatic amines, hydroxy aromatic aldehydes, hydroxy acetophenones and phenols using iodine and iodic acid in ethanol as a solvent. Notable advantages include mild reaction condition, no need of catalyst, short reaction time, simple practical procedure, giving excellent yield of the product.

Synthetic Communications published new progress about Aromatic compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 105752-04-3 belongs to class iodides-buliding-blocks, name is 4-Iodo-3-nitroaniline, and the molecular formula is C6H5IN2O2, Recommanded Product: 4-Iodo-3-nitroaniline.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Misal, Balu published the artcileSulfated polyborate-H2O assisted tunable activation of N-iodosuccinimide for expeditious mono and diiodination of arenes, Application In Synthesis of 21784-73-6, the main research area is arene iodosuccinimide sulfated polyborate catalyst regioselective iodination; iodoarene preparation.

Owing to both Lewis and Bronsted acid active sites on sulfated polyborate under homogeneous conditions, iodination protocol of arenes was developed, which can meet the requirement of regioselectivity and higher yield. The sulfated polyborate activated N-iodosuccinimide for mono iodination of highly activated substrates viz. phenols, anilines under anhydrous condition. Water tuned sulfated polyborate to generate more Bronsted acid sites resulting in rapid activation of NIS for diiodination. The protocol was equally applicable to diiodination of 4-hydroxyphenylacetic acid to synthesize 4-hydroxy-3,5-diiodophenylacetic acid, an intermediate of tiratricol, a thyroid treatment drug. This protocol was further integrated via one-pot sequential iodination and Sonogashira coupling to synthesize aryl acetylenes, building blocks for the synthesis of a variety of specialty chems., API and natural products.

Tetrahedron Letters published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 21784-73-6 belongs to class iodides-buliding-blocks, name is 4-Iodo-2-nitrophenol, and the molecular formula is C6H4INO3, Application In Synthesis of 21784-73-6.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Seath, Ciaran P. published the artcileSynthesis of 2-BMIDA 6,5-bicyclic heterocycles by Cu(I)/Pd(0)/Cu(II) cascade catalysis of 2-iodoaniline/phenols, Recommanded Product: 3-Iodo-5-nitropyridin-2-amine, the main research area is BMIDA bicyclic heterocycle preparation; iodoaniline boronic acid MIDA ester heterocyclization copper palladium catalyst.

A one-pot cascade reaction for the synthesis of 2-BMIDA 6,5-bicyclic heterocycles has been developed using Cu(II)/Pd(0)/Cu(II) catalysis. 2-Iodoanilines and phenols undergo a Cu(I)/Pd(0)-catalyzed Sonogashira reaction with ethynyl BMIDA followed by in situ Cu(II)-catalyzed 5-endo-dig cyclization to generate heterocyclic scaffolds with a BMIDA functional group in the 2-position. The method provides efficient access to borylated indoles, benzofurans, and aza-derivatives, which can be difficult to access through alternative methods.

Chemical Communications (Cambridge, United Kingdom) published new progress about Heterocyclic compounds, nitrogen Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 25391-56-4 belongs to class iodides-buliding-blocks, name is 3-Iodo-5-nitropyridin-2-amine, and the molecular formula is C5H4IN3O2, Recommanded Product: 3-Iodo-5-nitropyridin-2-amine.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Albadi, Jalal published the artcileRegioselective iodination of aromatic compounds with potassium iodide in the presence of benzyltriphenylphosphonium perchlorate, Application In Synthesis of 21784-73-6, the main research area is regioselective iodination aromatic compound potassium iodide benzyltriphenylphosphonium perchlorate.

A simple and efficient method for the selective iodination of various aromatic compounds by using potassium iodide in the presence of benzyltriphenylphosphonium perchlorate, is reported. This method provides several advantages such as good selectivity between ortho and para positions of aromatic compounds and high yields of the products.

Chinese Chemical Letters published new progress about Iodination, regioselective. 21784-73-6 belongs to class iodides-buliding-blocks, name is 4-Iodo-2-nitrophenol, and the molecular formula is C6H4INO3, Application In Synthesis of 21784-73-6.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Xia, Guoqin published the artcileLigand-Enabled β-Methylene C(sp3)-H Arylation of Masked Aliphatic Alcohols, SDS of cas: 685517-67-3, the main research area is methylene arylation aliphatic alc salicylic directing group pyridone ligand; C−H activation; aliphatic alcohols; directing groups; ligands; synthetic methods.

Despite recent advances, reactivity and site-selectivity remain significant obstacles for the practical application of C(sp3)-H bond functionalization methods. Here, we describe a system that combines a salicylic-aldehyde-derived L,X-type directing group with an electron-deficient 2-pyridone ligand to enable the β-methylene C(sp3)-H arylation of aliphatic alcs., which has not been possible previously. Notably, this protocol is compatible with heterocycles embedded in both alc. substrates and aryl coupling partners. A site- and stereo-specific annulation of dihydrocholesterol and the synthesis of a key intermediate of englitazone illustrate the practicality of this method.

Angewandte Chemie, International Edition published new progress about Arylation. 685517-67-3 belongs to class iodides-buliding-blocks, name is 2,6-Difluoro-3-iodopyridine, and the molecular formula is C5H2F2IN, SDS of cas: 685517-67-3.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reitti, Marcus published the artcileSynthesis of Phenols and Aryl Silyl Ethers via Arylation of Complementary Hydroxide Surrogates, Related Products of iodides-buliding-blocks, the main research area is diaryliodonium salt silanol arylation; hydrogen peroxide diaryliodonium salt arylation; aryl silyl ether preparation; phenol preparation.

Two transition-metal-free methods to access substituted phenols via the arylation of silanols or hydrogen peroxide with diaryliodonium salts are presented. The complementary reactivity of the two nucleophiles allows synthesis of a broad range of phenols without competing aryne formation, as illustrated by the synthesis of the anesthetic Propofol. Furthermore, silyl-protected phenols can easily be obtained, which are suitable for further transformations.

Organic Letters published new progress about Alkynes, arynes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 2100-25-6 belongs to class iodides-buliding-blocks, name is 3-Iodo-1,2,4,5-tetramethylbenzene, and the molecular formula is C10H13I, Related Products of iodides-buliding-blocks.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com