Month: November 2022

On September 7, 2006, Naidu, B. Narasimhulu; Banville, Jacques; Beaulieu, Francis; Connolly, Timothy P.; Krystal, Mark R.; Matiskella, John D.; Ouellet, Carl; Plamondon, Serge; Remillard, Roger; Sorenson, Margaret E.; Ueda, Yasutsugu; Walker, Michael A. published a patent.Reference of 1-(Bromomethyl)-4-fluoro-2-iodobenzene The title of the patent was Preparation of bicyclic heterocycles, particularly pyrimido[2,1-c][1,4]oxazine-2-carboxamides, as HIV integrase inhibitors. And the patent contained the following:

The invention is related to the preparation of title compounds I [R1 = C1-6(Ar1)alkyl, C1-6(Ar1)oxyalkyl, C1-6(Ar1)hydroxyalkyl, etc.; R2 = H, alkyl, OH, alkyloxy; Ar1 = (un)substituted Ph, naphthyl, benzothiophenyl, etc.; X-Y-Z = C(R3)2OC(R3)2, C(R3)2OC(R3)2C(R3)2, C(R3)2C(R3)2C(R3)2C(R3)2; R3 = H, alkyl], and their pharmaceutically acceptable salts or solvates which inhibit HIV integrase and prevent viral integration into human DNA. The invention is also related to the pharmaceutical compositions comprising pyrimidinones I, and methods of using them for treating HIV infection and AIDS. Thus, reacting ester II (preparation given) with 4-fluorobenzylamine in DMF/ethanol in the presence of TEA at 90掳 gave amide III in 82% yield. Selected I displayed IC50 values in the range of 0.002-0.1 渭M for the inhibition of HIV integrase activity. III demonstrated synergistic or additive-synergistic HIV antiviral activity when used in combination with other antiviral agents, e.g., zidovudine, indinavir, T-20, etc. The experimental process involved the reaction of 1-(Bromomethyl)-4-fluoro-2-iodobenzene(cas: 70931-59-8).Reference of 1-(Bromomethyl)-4-fluoro-2-iodobenzene

The Article related to bicyclic heterocycle hiv integrase inhibitor preparation, pyrimidooxazine carboxamide preparation hiv integrase inhibitor aids treatment, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Reference of 1-(Bromomethyl)-4-fluoro-2-iodobenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On February 17, 2009, Naidu, B. Narasimhulu; Sorenson, Margaret E.; Digiugno, Dawn published a patent.Formula: C7H5BrFI The title of the patent was Preparation of bicyclic heterocycles, particularly pyrimido[2,1-c][1,4]oxazine-2-carboxamides, as HIV integrase inhibitors. And the patent contained the following:

The invention is related to the preparation of title compounds I [R1 = C1-6(Ar1)alkyl, C1-6(Ar1)oxyalkyl, C1-6(Ar1)hydroxyalkyl, etc.; R2 = H, alkyl, OH, alkyloxy; Ar1 = (un)substituted Ph, naphthyl, benzothiophenyl, etc.; X-Y-Z = C(R3)2OC(R3)2, C(R3)2OC(R3)2C(R3)2, C(R3)2C(R3)2C(R3)2C(R3)2; R3 = H, alkyl], and their pharmaceutically acceptable salts or solvates which inhibit HIV integrase and prevent viral integration into human DNA. The invention is also related to the pharmaceutical compositions comprising pyrimidinones I, and methods of using them for treating HIV infection and AIDS. Thus, reacting ester II (preparation given) with 4-fluorobenzylamine in DMF/ethanol in the presence of TEA at 90掳 gave amide III in 82% yield. Selected I displayed IC50 values in the range of 0.002-0.1 渭M for the inhibition of HIV integrase activity. III demonstrated synergistic or additive-synergistic HIV antiviral activity when used in combination with other antiviral agents, e.g., zidovudine, indinavir, T-20, etc. Crystalline forms of III were prepared (crystal data were given). The experimental process involved the reaction of 1-(Bromomethyl)-4-fluoro-2-iodobenzene(cas: 70931-59-8).Formula: C7H5BrFI

The Article related to bicyclic heterocycle hiv integrase inhibitor preparation, pyrimidooxazine carboxamide preparation hiv integrase inhibitor aids treatment, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Formula: C7H5BrFI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On February 1, 2016, Beaudegnies, Renaud; Quaranta, Laura; Murphy Kessabi, Fiona; Lamberth, Clemens; Knauf-Beiter, Gertrud; Fraser, Torquil published an article.Category: iodides-buliding-blocks The title of the article was Synthesis and anti-oomycete activity of novel quinazolin- and benzothiazol-6-yloxyacetamides: Potent aza-analogs and five-ring analogs of quinoline fungicides. And the article contained the following:

Synthesis and anti-oomycete activity of quinazolines, e.g., I and benzothiazol-6-yloxyacetamide II was described. The synthesized compounds showed excellent in vivo activity against the three economically most important oomycete pathogens Phytophthora infestans, Plasmopara viticola and Pythium ultimum. These were polar analogs of known quinolin-6-yloxyacetamides, which were not active against the soil-borne damping-off disease caused by Pythium ultimum. The Bogert quinazoline synthesis, proved to be highly useful for the concise construction of required quinazolin-6-ol building blocks. The experimental process involved the reaction of Methyl 2-amino-5-iodo-3-methylbenzoate(cas: 1096481-48-9).Category: iodides-buliding-blocks

The Article related to preparation quinazoline benzothiazolyloxyacetamide anti oomycete sar, benzothiazole, crop protection, fungicide, heterocycle, quinazoline, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On February 4, 2021, Schenkel, Laurie B.; Vasbinder, Melissa Marie; Kuntz, Kevin Wayne; Perl, Nicholas Robert; Downing, Jennifer published a patent.Product Details of 1096481-48-9 The title of the patent was Preparation of pyrazolopyrimidine carboxamides and related heterobicyclic amides as inhibitors of CD38 useful in the treatment of cancer. And the patent contained the following:

The invention relates to preparation of pyrazolopyrimidine carboxamides and related heterobicyclic amides(I) which are inhibitors of CD38 and are useful in the treatment of cancer. Compounds I wherein V is N or CRv; Rv is H, halo, or C1-4 alkyl; W is N or CRw; Rw is H, halo, or C1-4 alkyl;; Ring A is a 5-membered heteroaryl group having 1, 2 or 3 ring-forming heteroatoms selected from N, O, and S; L is a C1-4 alkylene linker; n is 0 or 1; Q is H, C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, etc.; etc…, are claimed. The example compound II was prepared via 3-steps synthesis using imidazole as starting material (procedure given). Compounds I were evaluated for their biol. activity (data given). Compounds I can be useful in treatment of cancers. The experimental process involved the reaction of Methyl 2-amino-5-iodo-3-methylbenzoate(cas: 1096481-48-9).Product Details of 1096481-48-9

The Article related to pyrazolopyrimidine carboxamide preparation cd38 inhibitor antitumor cancer, heterobicyclic amide preparation cd38 inhibitor antitumor cancer, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Product Details of 1096481-48-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On June 7, 2007, Naidu, B. Narasimhulu; Banville, Jacques; Beaulieu, Francis; Connolly, Timothy P.; Krystal, Mark R.; Matiskella, John D.; Ouellet, Carl; Plamondon, Serge; Remillard, Roger; Sorenson, Margaret E.; Ueda, Yasutsugu; Walker, Michael A. published a patent.Computed Properties of 70931-59-8 The title of the patent was Bicyclic heterocycles, particularly 4-oxopyrimido[2,1-c][1,4]oxazine-2-carboxamide and 4-oxopyrimido[2,1-c][1,4]oxazepine-2-carboxamide derivatives, as HIV integrase inhibitors, their preparation, pharmaceutical compositions, and use in therapy. And the patent contained the following:

The invention is related to bicyclic pyrimidinone compounds, e.g. pyrimidooxazine I, which inhibit HIV integrase and prevent viral integration into human DNA. The invention is also related to the preparation of pharmaceutical compositions comprising a therapeutically effective amount of bicyclic pyrimidinones and a pharmaceutically acceptable carrier, optionally including a therapeutically effective amount of at least one other agent used for treatment of AIDS or HIV infection, as well as to the use of the compositions for the treatment of those infected with HIV. Thus, hydrogenolysis of dibenzyl compound II gave phosphonic acid I. I was tested for HIV integrase inhibition and for inhibition of HIV replication. The experimental process involved the reaction of 1-(Bromomethyl)-4-fluoro-2-iodobenzene(cas: 70931-59-8).Computed Properties of 70931-59-8

The Article related to pyrimidinone bicyclic preparation hiv integrase inhibitor, oxopyrimidooxazine oxopyrimidooxazepine carboxamide preparation hiv integrase inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Computed Properties of 70931-59-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On August 31, 1992, Mathias, Lon J.; Reichert, Veronica R.; Muir, Andrew V. G. published an article.Category: iodides-buliding-blocks The title of the article was Synthesis of macromolecules from 1,3,5,7-tetra(4-iodophenyl)adamantane: a new core for dendritic molecules. And the article contained the following:

The title compound was prepared by iodination of 1,3,5,7-tetraphenyladamantane and subsequently derivatized with 2-methyl-3-butyn-2-ol to give the tetrakis(3-hydroxy-3,3-dimethyl-1-propyn-1-yl) derivative (I) or with phenylboronic acid to give tetrabiphenylyladamantane. I was deprotected to give the ethynyl derivative The experimental process involved the reaction of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane(cas: 144970-30-9).Category: iodides-buliding-blocks

The Article related to adamantane macromonomer dendritic polymer, Chemistry of Synthetic High Polymers: Monomers and Reagents Used In Polymerization and other aspects.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On August 31, 2021, Rong, Meng; Yang, Liangrong; Yang, Chao; Yu, Jiemiao; Liu, Huizhou published an article.Quality Control of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane The title of the article was Tetraphenyladamantane-based microporous polyaminals for efficient adsorption of CO2, H2 and organic vapors. And the article contained the following:

Herein, a new tetraphenyladamantane-cored triazine-based multiamine (TPADT) was designed and synthesized. Its bulky mol. volume, strong rigidity, and high amine functionality enable it easy to prop up the polymer backbone and form a high hypercrosslinking degree to obtain high microporosity. A series of highly microporous tetraphenyladamantane-based polyaminals (Ad-MALPs) were prepared through the catalyst-free copolymerization of TPADT and com. aromatic aldehydes. By changing the strut length and functionality of aldehyde monomers, the resulting polymers exhibit tailored BET surface area (1541-1779 m2/g) and narrow ultra-micropore size distribution (0.52-0.93 nm). Ad-MALP-2 with the largest microporosity possesses the highest CO2 uptake (21.1 wt %, 273 K/1.0 bar) and CO2/N2 adsorption selectivity (35.2). Interestingly, Ad-MALP-3 shows the highest H2 uptake (2.26 wt%, 77 K/1.0 bar) due to larger total pore volume In addition, highly microporous Ad-MALPs simultaneously contain aromatic and cycloaliphatic components, and thus show exceptionally large aromatic and cycloaliphatic organic vapor adsorption capacity under low pressure. At P/P0 = 0.1, the benzene and cyclohexane vapor uptakes of Ad-MALPs are up to 44.8 wt% and 39.0 wt %, far exceeding that of most previously reported porous organic polymers. Considering that Ad-MALPs have outstanding gas adsorption performance, simple preparation, good stability, and cycle ability, they are expected to be promising adsorbent materials for CO2 adsorption/separation, H2 storage and low-concentration volatile organic vapors capture. The experimental process involved the reaction of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane(cas: 144970-30-9).Quality Control of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane

The Article related to tetraphenyladamantane microporous polyamine adsorption voc, Chemistry of Synthetic High Polymers: Organic Condensation and Step Polymerization and other aspects.Quality Control of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On September 14, 2010, Lim, Ho; Chang, Ji Young published an article.Recommanded Product: 1,3,5,7-Tetrakis(4-iodophenyl)adamantane The title of the article was Preparation of Clickable Microporous Hydrocarbon Particles Based on Adamantane. And the article contained the following:

The author’s prepared clickable microporous hydrocarbon particles based on an adamantane building block. The particle morphologies were controlled by varying the polymerization conditions. Spherical particles with a high surface area were obtained by the polymerization in a miniemulsion state. The polymer particles were easily modified via the click reaction, which provides a potential tool to tailor the chem. and phys. properties of porous particles to meet the requirements of specific applications. The experimental process involved the reaction of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane(cas: 144970-30-9).Recommanded Product: 1,3,5,7-Tetrakis(4-iodophenyl)adamantane

The Article related to preparation click chem adamantane adsorbent microemulsion polymerization polyacetylene, Chemistry of Synthetic High Polymers: Organic Condensation and Step Polymerization and other aspects.Recommanded Product: 1,3,5,7-Tetrakis(4-iodophenyl)adamantane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On March 31, 1993, Reichert, Veronica R.; Mathias, Lon J. published an article.Related Products of 144970-30-9 The title of the article was Rigid-expanded tetrahedral cores for four-armed branched structures: 1,3,5,7-tetrakis(4-iodophenyl)adamantane and its derivatives. And the article contained the following:

1,3,5,7-Tetrakis(4-iodophenyl)adamantane (I) was an ideal starting material for the preparation of rigid, expanded tetrahedral core mols. Pd-catalyzed coupling of I with 1-decene gave acceptable yields of 1,3,5,7-tetrakis(1-decenyl)adamantane, a model for all-hydrocarbon star-polymer systems. 1,3,5,7-Tetrakis(4-carboxyphenyl)adamantane (II) was obtained from a Grignard-type reaction of I with sec-BuLi followed by reaction with CO2 and acidification. Direct condensation of II with 1-aminoadamantane in the presence of triphenylphosphine and hexachloroethane gave the tetra-adamantyl amide. These monomers could be used for the preparation of macromols. with enforced 3-dimensional structures. The experimental process involved the reaction of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane(cas: 144970-30-9).Related Products of 144970-30-9

The Article related to tetrakisiodophenyl adamantane preparation, tetrahedral adamantane derivative nmr spectrum, ir spectrum tetrahedral adamantane derivative, Chemistry of Synthetic High Polymers: Monomers and Reagents Used In Polymerization and other aspects.Related Products of 144970-30-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On November 21, 1994, Reichert, Veronica R.; Mathias, Lon J. published an article.Formula: C34H28I4 The title of the article was Tetrahedrally-Oriented Four-Armed Star and Branched Aramids. And the article contained the following:

Palladium-catalyzed carbonylation of 4-iodoaniline in the presence of 1,3,5,7-tetrakis(4-iodophenyl)adamantane or 1,3,5,7-tetrakis(4-aminophenyl)adamantane cores gave the corresponding four-armed star polybenzamides. Tetraphenyladamantane incorporation was confirmed by 13C solution and solid-state CP/MAS NMR and FTIR. The stars exhibited the same thermal stability as linear polybenzamide synthesized by the same route. The star with the amine core exhibited the highest intrinsic viscosity in sulfuric acid ([畏] = 0.74 dL/g), and films could be cast from dilute DMAC-5% LiCl solutions Tetraphenyladamantane incorporation (confirmed by solid-state CP/MAS 13C NMR and FTIR) significantly increased solubility Branched aramids synthesized from 3,5-dibromoaniline under Pd-catalyzed carbonylation conditions were compared to a branched system based on 1,3,5,7-tetrakis(4-iodophenyl)adamantane. The former were insoluble, while the adamantane materials were slightly soluble in DMAC and H2SO4; both hyperbranched polymers tenaciously held residual solvent and could not be completely dried. These results confirm both the incorporation of the tetrasubstituted adamantyl core into both star and hyperbranched polymers and the possibility of property modification through disruption of chain packing and enforced tetrahedral arm orientation at the core. The experimental process involved the reaction of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane(cas: 144970-30-9).Formula: C34H28I4

The Article related to adamantane catalyst polycondensation iodoaniline, polyamide star preparation adamantane core, aramid star preparation tetrakisiodophenyladamantane, Chemistry of Synthetic High Polymers: Organic Condensation and Step Polymerization and other aspects.Formula: C34H28I4

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com