Month: November 2022

On March 26, 2015, Tokito, Shizuo; Kumaki, Daisuke; Mamada, Masashi; Fukuda, Kenjiro; Tanaka, Yasuhiro; Shima, Hidetaka; Yoneda, Yasuhiro; Fujita, Harunori; Kakita, Kazuaki; Omata, Youji; Yamada, Natsuko; Honma, Takashi; Machida, Toshikazu published a patent.Quality Control of 5-Bromo-2-iodobenzotrifluoride The title of the patent was Preparation of benzobis(thiadiazole) derivatives, ink containing them, and organic electronic device using them. And the patent contained the following:

The present invention pertains to a benzobis(thiadiazole) derivative represented by general formula [I; R1 = straight-chain or branched alkyl group or any of group A; group A = , NO2, F, Br, CF3, SCF3, C(R)F2, cyano, CO2R, Cl, iodo, OCF3, SF6, OC(R)F2, or OC(O)R, SC(R)F2; R2 = H; R3 = H, straight-chain or branched alkyl group, or any of group A; at least one R1 and R3 = one of the group A; the two R1s, two R2s, and two R3s may be identical to or different from one another; R = straight-chain or branched alkyl group]. These compounds are thermally stable, soluble in organic solvents, capable of fabricating thin films by coating method, stable in the air, and are excellent in hole and/or electron field effect mobility (渭FE) and are useful for organic electronic devices such as organic thin film transistor, organic electroluminescent device, display devices, displays, and solar cells. The use of these compounds in the semiconductor layer of organic thin film transistor (TFT), high field effect mobility characteristic is realized. When they are used in the hole or electron transport layer of organic electroluminescent device, high luminescent efficiency is realized. When using in the charge-separation layer, hole transport layer, or electron transport layer of solar cells, high incident photon to current conversion efficiency (IPCE) is realized. Thus, 4,7-dibromobenzo[1,2-c:4,5-c’]bis[1,2,5]thiadiazole was coupled with 2-(tributylstannyl)-5-[3-(trifluoromethoxy)phenyl]thiophene in the presence of dichlorobis(triphenylphosphine)palladium in anhydrous toluene at 100掳 (inner temperature) for 6 h, followed by filtration of the crude product (2.1 g) and sublimation for purification to give 0.25 g compound (II) as green solid. The solubility of II was 0.1 weight% in toluene at 100掳, 0.1 weight% in mesitylene at 80掳, and 0.3 weight% in mesitylene at 130掳. A semiconductor ink containing 0.2 weight% II in Me salicylate was added dropwise into a barrier rib pattern on a polyvinylphenol-melamine thin film (formed on a glass substrate with an aluminum gate electrode), dried at 80掳 to form an organic semiconductor layer on which gold film was vacuum-deposited as source and drain electrode. The fabricated organic TFT had field effect mobility of 6.3 X 10-1 cm2/Vs. The experimental process involved the reaction of 5-Bromo-2-iodobenzotrifluoride(cas: 364-12-5).Quality Control of 5-Bromo-2-iodobenzotrifluoride

The Article related to organic thin film transistor benzobisthiadiazole semiconductor layer, benzobisthiadiazole preparation solar cell organic electroluminescent device, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Quality Control of 5-Bromo-2-iodobenzotrifluoride

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On July 7, 2022, Jin, Jinghai; Shen, Chunli; Wu, Chengde; Chen, Shuhui published a patent.Recommanded Product: 364-12-5 The title of the patent was Preparation of selinexor analogs as XOP1 inhibitors. And the patent contained the following:

The invention relates to selinexor analogs (e.g., I) pharmaceutically acceptable salts thereof; pharmaceutical preparation comprising them; and their use as XOP1 inhibitors. The experimental process involved the reaction of 5-Bromo-2-iodobenzotrifluoride(cas: 364-12-5).Recommanded Product: 364-12-5

The Article related to selinexor analog antitumor xop1 inhibitor preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Recommanded Product: 364-12-5

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On August 28, 2014, Bartberger, Michael D.; Beck, Hilary Plake; Degraffenreid, Michael R.; Fox, Brian M.; Gonzalez Lopez De Turiso, Felix; Julian, Lisa D.; Kayser, Frank; Medina, Julio C.; Olson, Steven H.; Rew, Yosup; Roveto, Philip M.; Sun, Daqing; Yan, Xuelei published a patent.Related Products of 70931-59-8 The title of the patent was Preparation of cis-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer. And the patent contained the following:

The title compounds [I; X = O or S(O)2; R1 = H, C1-6alkyl, (CReRe)nC6-8aryl, (CReRe)nC3-8cycloalkyl, (CReRe)n-3-8 membered heterocycloalkyl, S(O)2C3-8cycloalkyl, C(O)C3-8cycloalkyl, or CRfRa(CReRe)n-Q; Q = (CReRe)nC6-8aryl, (CReRe)n-3-8 membered heterocycloalkyl, (CReRe)n-5-8 membered heteroaryl, (CReRe)nC3-8cycloalkyl, cyano, (CReRe)nOH, CO2H, NReRe, etc.; R2 = H, C1-6alkyl, (CReRe)nC(O)ORe, (CReRe)nNReRe, (CReRe)nC(O)NReRe, (CReRe)nOH, (CReRe)nC(O)H, (CReRe)nC6-8aryl, (CReRe)n-3-8 membered heterocycloalkyl, (CReRe)n-5-8 membered heteroaryl, (CReRe)nCN, -(CReRe)nC(O)5-8 membered heterocycloalkyl, etc.; any heteroaryl or heterocycloalkyl group has one or more heteroatoms independently selected from O, N or S; any cycloalkyl, heterocycloalkyl, heteroaryl or aryl group can be unsubstituted or substituted; R3 = H or C1-6alkyl; R4 = C6-8 aryl or 5-9 membered heteroaryl; R5 = C6-8 aryl or 5-9 membered heteroaryl; R6, R7 = H or C1-6alkyl; Ra = independently H, C1-6alkyl, C2-6alkenyl, (CReRe)nC3-8cycloalkyl, or (CReRe)nC6-8aryl, wherein any cycloalkyl or aryl group can be unsubstituted or substituted; Re, Rf = independently H, C1-6alkyl , or OH; n, m = independently 0-4; provided that R2 and R3 are not both H] or pharmaceutically acceptable salts thereof were prepared These compounds including morpholinone and 2,5,6,8-tetrahydro-3H-imidazo[2,1-c][1,4]oxazine derivatives are inhibitors of MDM2 (oncoprotein) and are useful as therapeutic agents, particularly for the treatment of cancers. The cancer is selected from bladder, breast, colon, rectum, kidney, liver, small cell lung cancer, non-small-cell lung cancer, esophagus, gall bladder, ovary, pancreas, stomach, cervix, thyroid, prostate, skin, acute lymphocytic leukemia, chronic myelogenous leukemia, acute lymphoblastic leukemia, B-cell lymphoma, T-cell lymphoma, Hodgkin’s lymphoma, non-Hodgkin’s lymphoma, hairy cell lymphoma, Burkitt’s lymphoma, acute and chronic myelogenous leukemia, melanoma, endometrial cancer, head and neck cancer, glioblastoma, or osteosarcoma. Thus, cyclocondensation of rel-(1R,2S)-1,2-bis(4-bromophenyl)-2-(methylamino)ethanol with 2-chloroacetyl chloride in the presence of Et3N in THF at 0掳 for 1 h gave rel-(5R,6S)-5,6-Bis(4-bromophenyl)-4-methylmorpholin-3-one which was treated with sodium bis(trimethylsilyl)amide in THF at -78掳 for 20 min and then underwent benzylation with benzyl bromide at -78掳 for 30 min and at room temperature for 30 min to give rel-(2S,5R,6S)-2-benzyl-5,6-bis(4-bromophenyl)-4-methylmorpholin-3-one (II). II and 2-[rel-(2S,5R,6S)-4-benzyl-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl]acetic acid (III) showed IC50 of 1.96 and 0.0399 渭M, resp., for inhibiting the interaction of GST-hMDM2 and biotinylated-p53 in an homogeneous time-resolved fluorescence assay (HTRF1 assay). The experimental process involved the reaction of 1-(Bromomethyl)-4-fluoro-2-iodobenzene(cas: 70931-59-8).Related Products of 70931-59-8

The Article related to mdm2 oncoprotein inhibitor morpholinone tetrahydroimidazooxazine, morpholinone tetrahydroimidazooxazine preparation treatment cancer, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Related Products of 70931-59-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On December 13, 2018, Bartberger, Michael D.; Beck, Hilary Plake; Degraffenreid, Michael R.; Fox, Brian M.; Gonzalez Lopez De Turiso, Felix; Julian, Lisa D.; Kayser, Frank; Medina, Julio C.; Olson, Steven H.; Rew, Yosup; Roveto, Philip M.; Sun, Daqing; Yan, Xuelei published a patent.Electric Literature of 70931-59-8 The title of the patent was Preparation of cis-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer. And the patent contained the following:

The invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor. The title compounds [I; X = O or S(O)2; R1 = H, C1-6alkyl, (CReRe)nC6-8aryl, (CReRe)nC3-8cycloalkyl, (CReRe)n-3-8 membered heterocycloalkyl, S(O)2C3-8cycloalkyl, C(O)C3-8cycloalkyl, or CRfRa(CReRe)n-Q; Q = (CReRe)nC6-8aryl, (CReRe)n-3-8 membered heterocycloalkyl, (CReRe)n-5-8 membered heteroaryl, (CReRe)nC3-8cycloalkyl, cyano, (CReRe)nOH, CO2H, NReRe, etc.; R2 = H, C1-6alkyl, (CReRe)nC(O)ORe, (CReRe)nNReRe, (CReRe)nC(O)NReRe, (CReRe)nOH, (CReRe)nC(O)H, (CReRe)nC6-8aryl, (CReRe)n-3-8 membered heterocycloalkyl, (CReRe)n-5-8 membered heteroaryl, (CReRe)nCN, -(CReRe)nC(O)5-8 membered heterocycloalkyl, etc.; any heteroaryl or heterocycloalkyl group has one or more heteroatoms independently selected from O, N or S; any cycloalkyl, heterocycloalkyl, heteroaryl or aryl group can be unsubstituted or substituted; R3 = H or C1-6alkyl; R4 = C6-8 aryl or 5-9 membered heteroaryl; R5 = C6-8 aryl or 5-9 membered heteroaryl; R6, R7 = H or C1-6alkyl; Ra = independently H, C1-6alkyl, C2-6alkenyl, (CReRe)nC3-8cycloalkyl, or (CReRe)nC6-8aryl, wherein any cycloalkyl or aryl group can be unsubstituted or substituted; Re, Rf = independently H, C1-6alkyl , or OH; n, m = independently 0-4; provided that R2 and R3 are not both H] or pharmaceutically acceptable salts thereof were prepared These compounds including morpholinone and 2,5,6,8-tetrahydro-3H-imidazo[2,1-c][1,4]oxazine derivatives are inhibitors of MDM2 (oncoprotein) and are useful as therapeutic agents, particularly for the treatment of cancers. Thus, cyclocondensation of rel-(1R,2S)-1,2-bis(4-bromophenyl)-2-(methylamino)ethanol with 2-chloroacetyl chloride gave rel-(5R,6S)-5,6-bis(4-bromophenyl)-4-methylmorpholin-3-one which was treated with sodium bis(trimethylsilyl)amide followed by benzylation with benzyl bromide yo give rel-(2S,5R,6S)-2-benzyl-5,6-bis(4-bromophenyl)-4-methylmorpholin-3-one (II). II and 2-[rel-(2S,5R,6S)-4-benzyl-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl]acetic acid (III) showed IC50 of 1.96 and 0.0399 渭M, resp., for inhibiting the interaction of GST-hMDM2 and biotinylated-p53 in an homogeneous time-resolved fluorescence assay (HTRF1 assay). The experimental process involved the reaction of 1-(Bromomethyl)-4-fluoro-2-iodobenzene(cas: 70931-59-8).Electric Literature of 70931-59-8

The Article related to mdm2 oncoprotein inhibitor morpholinone tetrahydroimidazooxazine, morpholinone tetrahydroimidazooxazine preparation treatment cancer, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Electric Literature of 70931-59-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ma, Zhihua; Dong, Wenyue; Hou, Jianhua; Duan, Qian; Shao, Shiyang; Wang, Lixiang published an article in 2019, the title of the article was Dendritic host materials with non-conjugated adamantane cores for efficient solution-processed blue thermally activated delayed fluorescence OLEDs.Reference of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane And the article contains the following content:

Two dendritic host materials consisting of non-conjugated adamantane cores and four first-/second-generation carbazole dendrons (Ad-4D1 and Ad-4D2) are developed for efficient solution-processed blue thermally activated delayed fluorescence (TADF) organic light-emitting diodes (OLEDs). The dendrimers with three-dimensional geometries, which are constructed through facile one-step palladium-catalyzed C-N coupling reactions involving tetra-substituted adamantane and carbazole dendrons, show high thermal stability and excellent solubility in common organic solvents. The dendrimers possess high triplet energies (ETs) of 2.83-2.95 eV, making them suitable to host blue TADF emitters. Compared with Ad-4D1 with the first-generation dendrons showing a deep HOMO (HOMO) level of -5.51 eV, Ad-4D2 with the second-generation ones exhibits an elevated HOMO level of -5.32 eV, favorable for hole injection from anode to the emissive layer. Solution-processed blue TADF OLEDs utilizing Ad-4D2 as a host exhibit promising device performance with a maximum luminous efficiency, power efficiency and external quantum efficiency of 44.2 cd A-1, 34.4 lm W-1 and 18.3%, resp., among the highest values for solution-processed blue TADF OLEDs. This work sheds light on the development of dendritic host materials, as an alternative to soluble small-mol. hosts and polymer hosts, to realize high-efficiency solution-processed TADF OLEDs. The experimental process involved the reaction of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane(cas: 144970-30-9).Reference of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane

The Article related to nonconjugated adamantane core dendritic host material tadf oled, Optical, Electron, and Mass Spectroscopy and Other Related Properties: Spectrometers and Optical Apparatus and other aspects.Reference of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Thyagarajan, Sujatha; Galoppini, Elena published an article in 2008, the title of the article was Synthetic approaches to study aggregation of tripodal linkers on semiconductor surfaces.Product Details of 144970-30-9 And the article contains the following content:

Two tripod-shaped adamantane derivatives carrying a pyrene chromophore and three carboxylic acid binding groups, and varying in footprint size (鈭?0.7 and 2.7 nm2), were synthesized as models to study how the footprint size can influence the aggregation of organic dyes bound to ZrO2 thin films. Synthetic approaches and binding properties of large footprint tripodal linkers are discussed. The experimental process involved the reaction of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane(cas: 144970-30-9).Product Details of 144970-30-9

The Article related to semiconductor surface tripodal linker aggregation, Electrochemical, Radiational, and Thermal Energy Technology: Energy-Conversion Devices and Their Components and other aspects.Product Details of 144970-30-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On May 1, 2007, Suga, Takeo; Pu, Yong-Jin; Kasatori, Shinji; Nishide, Hiroyuki published an article.Safety of 5-Bromo-2-iodobenzotrifluoride The title of the article was Cathode- and Anode-Active Poly(nitroxylstyrene)s for Rechargeable Batteries: p- and n-Type Redox Switching via Substituent Effects. And the article contained the following:

Three polystyrenes bearing redox-active nitroxide radical(s) in each repeating unit, poly[4-(N-tert-butyl-N-oxylamino)styrene] (1), poly[3,5-di(N-tert-butyl-N-oxylamino)styrene] (2), and poly[4-(N-tert-butyl-N-oxylamino)-3-trifluoromethylstyrene] (3), were synthesized via free radical polymerization of protected precursor styrenic derivatives and subsequent chem. oxidation The radicals in these polymers were robust at ambient conditions, and the polymers possessed radical densities of 2.97 脳 1021, 4.27 脳 1021, and 1.82 脳 1021 unpaired electrons/g for 1-3, resp., resulting in an electrode-active material with a high charge/discharge capacity. Particularly, the dinitroxide functional polymer 2 possessed the highest radical d. Cyclic voltammetry of the poly(nitroxylstyrene) 1 revealed a reversible redox at 0.74 V vs. Ag/AgCl, which was assigned to the oxidation of the nitroxide radical to form the oxoammonium cation (p-type doped state). However, the poly(nitroxylstyrene) ortho-substituted with the electron-withdrawing trifluoromethyl Group 3 showed a reversible redox at -0.76 V, ascribed to the n-type redox pair between the nitroxide radical and the aminoxy anion. Thus, the nitroxide radical polymer could be switched from p-type material suitable for a cathode to n-type material (anode-active) via altering the electron-withdrawing character of the substituents on the poly(nitroxylstyrene). This is the 1st report of an n-type radical polymer and the 1st report of using substituent effects to switch the redox behavior of the polymer. This versatile switching ability enables these polymers to function as components of metal-free electrodes in rechargeable batteries. The experimental process involved the reaction of 5-Bromo-2-iodobenzotrifluoride(cas: 364-12-5).Safety of 5-Bromo-2-iodobenzotrifluoride

The Article related to cathode anode poly nitroxylstyrene rechargeable battery switching redox, Electrochemical, Radiational, and Thermal Energy Technology: Energy-Conversion Devices and Their Components and other aspects.Safety of 5-Bromo-2-iodobenzotrifluoride

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Linsenmeier, Anna M.; Williams, Craig M.; Brase, Stefan published an article in 2013, the title of the article was Photochemical Synthesis of Phenanthridines: Exploring Fluoro and Protected Catechol Substitution.Name: 1-(Bromomethyl)-4-fluoro-2-iodobenzene And the article contains the following content:

Substituted phenanthridines, such as the natural product trispheridine, have been accessed by the practical photochem. cyclization of N-benzylanilines. Functionalities, with a focus on fluoro substituents and protected catechols, are well tolerated on both the A and C rings. The phenanthridines were accessed in good to very good yields (up to 95 %) from iodinated substrates, whereas brominated substrates performed poorly in comparison (0-48 %). The experimental process involved the reaction of 1-(Bromomethyl)-4-fluoro-2-iodobenzene(cas: 70931-59-8).Name: 1-(Bromomethyl)-4-fluoro-2-iodobenzene

The Article related to iodobenzylaniline fluoro protected catechol containing photochem cyclization, phenanthridine preparation, Heterocyclic Compounds (One Hetero Atom): Other Areno- and Diarenopyridines (Acridines, Quinolizines, etc.) and other aspects.Name: 1-(Bromomethyl)-4-fluoro-2-iodobenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On April 12, 2007, Chung, Young-Keun; Jung, Il-Gu; Chun, Sung-Ho; Park, Young-Whan; Yoon, Sung-Cheol; Lim, Taesun; Lee, Jungmin; Choi, Dai-Seung published a patent.Recommanded Product: 934008-48-7 The title of the patent was Metal complex catalysts for polymerizing cyclic olefins. And the patent contained the following:

Cyclic olefin-based monomers are polymerized using a metal catalyst complex represented by: [M(L1)x(L’2)y(L3)z]a[Ani]b wherein M is a Group X metal; [M(L1)x (L’2)y(L3)z] is a cationic precatalyst; L1 is an anionic hydrocarbyl-containing ligand; L’2 is a neutral ligand; L3 is an N-heterocyclic carbene ligand; [Ani] is an anion capable of weakly coordinating with the metal M; x is 1 or 2; y is 0 to 4; z is 1 or 2; 2鈮+y+z鈮?; a and b are each 1 to 10. The metal catalyst complex has an N-heterocyclic carbene ligand, and thus, is excellent in thermal stability and reactivity. The experimental process involved the reaction of 1H-Imidazolium, 1,3-bis[4-iodo-2,6-bis(1-methylethyl)phenyl]-, chloride (1:1)(cas: 934008-48-7).Recommanded Product: 934008-48-7

The Article related to cyclic olefin polymerization metal complex catalyst, Chemistry of Synthetic High Polymers: Polymerization Kinetics, Mechanisms, Thermodynamics, Catalysis, Catalysts and other aspects.Recommanded Product: 934008-48-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Lee, Hyunpyo; Kim, Hyungwoo; Choi, Tae Jin; Park, Hyun Woo; Chang, Ji Young published an article in 2015, the title of the article was Preparation of a microporous organic polymer by the thiol-yne addition reaction and formation of Au nanoparticles inside the polymer.Category: iodides-buliding-blocks And the article contains the following content:

A microporous polymer with sulfide and thiol groups was synthesized using the thiol-yne reaction. Au nanoparticles were prepared by in situ reduction reaction inside the polymer and were found to be well dispersed. The Au-containing polymer showed catalytic activity in the reduction of 4-nitrophenol. The experimental process involved the reaction of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane(cas: 144970-30-9).Category: iodides-buliding-blocks

The Article related to microporous organic polymer thiolyne gold nanoparticle, Chemistry of Synthetic High Polymers: Polymerization Kinetics, Mechanisms, Thermodynamics, Catalysis, Catalysts and other aspects.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com