Month: December 2022

Ragan, J. A. published the artcileCross-Coupling Methods for the Large-Scale Preparation of an Imidazole-Thienopyridine: Synthesis of [2-(3-Methyl-3H-imidazol-4-yl)- thieno[3,2-b]pyridin-7-yl]-(2-methyl-1H-indol-5-yl)-amine, Related Products of iodides-buliding-blocks, the publication is Organic Process Research & Development (2003), 7(5), 676-683, database is CAplus.

The multihundred-gram synthesis of imidazolyl-substituted thienopyridine I was developed utilizing a Stille cross-coupling of iodothienopyridine II with 5-(tributylstannyl)-1-methylimidazole. Several cross-coupling methods were evaluated for the conversion of II to (imidazolyl)thienopyridine III, but only two were effective: the Stille coupling and a Negishi cross-coupling of II with the organozinc reagent derived from 2-(tert-butyldimethylsilyl)-1-methylimidazole. The latter procedure worked well on laboratory scale (<50 g), but was capricious upon scale-up. The issues with scale-up of an organostannane reagent are discussed, including control and anal. of organotin levels.

Organic Process Research & Development published new progress about 602303-26-4. 602303-26-4 belongs to iodides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Iodide, name is 7-Chloro-2-iodothieno[3,2-b]pyridine, and the molecular formula is C7H3ClINS, Related Products of iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Yaddanapudi, Kavitha published the artcileControl of Tumor-Associated Macrophage Alternative Activation by Macrophage Migration Inhibitory Factor, SDS of cas: 41270-96-6, the publication is Journal of Immunology (2013), 190(6), 2984-2993, database is CAplus and MEDLINE.

Tumor stromal alternatively activated macrophages are important determinants of antitumor T lymphocyte responses, intratumoral neovascularization, and metastatic dissemination. Our recent efforts to investigate the mechanism of macrophage migration inhibitory factor (MIF) in antagonizing antimelanoma immune responses reveal that macrophage-derived MIF participates in macrophage alternative activation in melanoma-bearing mice. Both peripheral and tumor-associated macrophages (TAMs) isolated from melanoma bearing MIF-deficient mice display elevated proinflammatory cytokine expression and reduced anti-inflammatory, immunosuppressive, and proangiogenic gene products compared with macrophages from tumor-bearing MIF wild-type mice. Moreover, TAMs and myeloid-derived suppressor cells from MIF-deficient mice exhibit reduced T lymphocyte immunosuppressive activities compared with those from their wild-type littermates. Corresponding with reduced tumor immunosuppression and neo-angiogenic potential by TAMs, MIF deficiency confers protection against transplantable s.c. melanoma outgrowth and melanoma lung metastatic colonization. Finally, we report for the first time, to our knowledge, that our previously discovered MIF small mol. antagonist, 4-iodo-6-phenylpyrimidine, recapitulates MIF deficiency in vitro and in vivo, and attenuates tumor-polarized macrophage alternative activation, immunosuppression, neoangiogenesis, and melanoma tumor outgrowth. These studies describe an important functional contribution by MIF to TAM alternative activation and provide justification for immunotherapeutic targeting of MIF in melanoma patients.

Journal of Immunology published new progress about 41270-96-6. 41270-96-6 belongs to iodides-buliding-blocks, auxiliary class Pyrimidine,Iodide,Benzene,Immunology/Inflammation,MIF, name is 4-Iodo-6-phenylpyrimidine, and the molecular formula is C18H20N2O12, SDS of cas: 41270-96-6.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Suga, Takeo published the artcileCathode- and Anode-Active Poly(nitroxylstyrene)s for Rechargeable Batteries: p- and n-Type Redox Switching via Substituent Effects, Formula: C7H3BrF3I, the publication is Macromolecules (Washington, DC, United States) (2007), 40(9), 3167-3173, database is CAplus.

Three polystyrenes bearing redox-active nitroxide radical(s) in each repeating unit, poly[4-(N-tert-butyl-N-oxylamino)styrene] (1), poly[3,5-di(N-tert-butyl-N-oxylamino)styrene] (2), and poly[4-(N-tert-butyl-N-oxylamino)-3-trifluoromethylstyrene] (3), were synthesized via free radical polymerization of protected precursor styrenic derivatives and subsequent chem. oxidation The radicals in these polymers were robust at ambient conditions, and the polymers possessed radical densities of 2.97 × 10²¹, 4.27 × 10²¹, and 1.82 × 10²¹ unpaired electrons/g for 1-3, resp., resulting in an electrode-active material with a high charge/discharge capacity. Particularly, the dinitroxide functional polymer 2 possessed the highest radical d. Cyclic voltammetry of the poly(nitroxylstyrene) 1 revealed a reversible redox at 0.74 V vs. Ag/AgCl, which was assigned to the oxidation of the nitroxide radical to form the oxoammonium cation (p-type doped state). However, the poly(nitroxylstyrene) ortho-substituted with the electron-withdrawing trifluoromethyl Group 3 showed a reversible redox at -0.76 V, ascribed to the n-type redox pair between the nitroxide radical and the aminoxy anion. Thus, the nitroxide radical polymer could be switched from p-type material suitable for a cathode to n-type material (anode-active) via altering the electron-withdrawing character of the substituents on the poly(nitroxylstyrene). This is the 1st report of an n-type radical polymer and the 1st report of using substituent effects to switch the redox behavior of the polymer. This versatile switching ability enables these polymers to function as components of metal-free electrodes in rechargeable batteries.

Macromolecules (Washington, DC, United States) published new progress about 364-12-5. 364-12-5 belongs to iodides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Bromide,Iodide,Benzene, name is 5-Bromo-2-iodobenzotrifluoride, and the molecular formula is C9H7NO2, Formula: C7H3BrF3I.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Schmidt, Stefanie published the artcileDual IGF-1R/SRC inhibitors based on a N’-aroyl-2-(1H-indol-3-yl)-2-oxoacetohydrazide structure, SDS of cas: 39115-95-2, the publication is European Journal of Medicinal Chemistry (2011), 46(7), 2759-2769, database is CAplus and MEDLINE.

The N’-aroyl-2-(1H-indol-3-yl)-2-oxoacetohydrazide motif was identified as a novel scaffold for the development of kinase inhibitors. Derivatives with a biphenyl element attached to the hydrazide structure proved to be submicromolar dual inhibitors of the cancer-related kinases IGF-1R and SRC. One of the most potent kinase inhibitors of the series, I, produced a selective growth inhibition in a panel of cultivated cancer cell lines.

European Journal of Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, SDS of cas: 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

McDermott, Todd S. published the artcileProcess research and initial scale-up of ABT-839: A farnesyl-transferase inhibitor, Name: Dimethyl 2-iodoterephthalate, the publication is ACS Symposium Series (2004), 59-69, database is CAplus.

The antitumor compound ABT-839 was synthesized in eight steps from com. available starting materials. The synthesis was carried out with a single purification prior to final salt isolation. The key sequence is an efficient bromination and a novel bis-coupling strategy that transforms the bi-aryl core to the penultimate ester in a single operation with no isolation in 94% yield. After bisulfate salt formation, the product was isolated as a crystalline solid. The synthesis was carried out on kilogram scale and gave an overall yield of 43%.

ACS Symposium Series published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C10H9IO4, Name: Dimethyl 2-iodoterephthalate.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Li, Zhe published the artcileFluorinated triphenylenes and a path to short tailed discotic liquid crystals: synthesis, structure and transport properties, COA of Formula: C6H13I, the publication is Materials Advances (2022), 3(1), 534-546, database is CAplus.

A new synthetic approach for fluorinated alkoxytriphenylene discotic liquid crystals is presented. This methodol. exploits the previously described photocyclodehydrofluorination (PCDHF) reaction for the preparation of fluorinated triphenylene derivatives coupled with a variety of nucleophilic aromatic substitution (S_NAr) reactions. This particular combination of reactions provides a versatile route to discotic materials with carefully controlled core fluorine and alkoxy tail content. In the course of these studies, new discotic materials with minimal tail content have been revealed. The mesogenic properties of these materials are reported, and their charge transport properties are measured using the time of flight technique.

Materials Advances published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, COA of Formula: C6H13I.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Yagi, Yoshiharu published the artcileChemistry of halogens and of polyhalides. XXVI. Infrared absorption spectra of iodine bromide and its complexes, Recommanded Product: Pyridine Iodochloride complex, the publication is Journal of Physical Chemistry (1967), 71(8), 2439-44, database is CAplus.

The influence of complexation on the frequency of the I-Br fundamental stretching vibration in iodine bromide complexes has been investigated. The frequency and the intensity of this band are strongly influenced by the strength of the iodine bromide-electron donor interaction. The position of the IBr band varies from 261 cm.-1 in CCl4 solutions to 205 cm.-1 for the pyridine-IBr complex dissolved in benzene. In solid complexes the IBr band is split into a doublet. The changes in frequency are analyzed to obtain changes in force constants Some attempt is made to interpret these results. 31 references.

Journal of Physical Chemistry published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C39H35N5O8, Recommanded Product: Pyridine Iodochloride complex.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Yagi, Yoshiharu published the artcileNew polyhalide complex ions, Recommanded Product: Pyridine Iodochloride complex, the publication is Inorganic and Nuclear Chemistry Letters (1965), 1(1), 21-4, database is CAplus.

Polyhalide complexes of the type A.HICl₂.ICl (A = organic base) were prepared by dissolving a A.HICl₂ complex in 1,2-dichloroethane, adding a 4-5 fold excess of ICl, and diluting the resulting solution with CCl₄. The compounds prepared and their m.ps. are: 2,2′-bp.HICl₂.ICl (65-7°) (bp = bipyridine); 4,4′-Me₃-2,2′-bp.HICl₂.ICl (57-9°); 2,2′-bq.HICl₂.ICl (139-40°) (bq = biquinoline); 1,10-phen.HICl₂.ICl (96.5-7.5°) (phen = phenanthroline); 2,9-Me₂-1,10-phen.HICl₂.ICl (97-8°); 4,7-Me_2-1,10-phen.HICl₂.ICl (114-15°); py.HICl₂.ICl (85-6°); 2,6-lu.HICl₂.ICl (lu = lutidine); and Me₄N.ICl₂.ICl. The last 2 were red-orange oils which, on cooling, solidified to glasses; the others precipitated as orange microcrystalline powders. All are quite stable at room temperature They decomposed slowly by atm. moisture. They are soluble in many organic solvents (except CCl₄), dissociating to A.HICl₂ and ICl. They lose a mole of ICl on heating to ∼100°. Ir data seems to indicate the I₂Cl₃^– ion.

Inorganic and Nuclear Chemistry Letters published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C26H26N4O7, Recommanded Product: Pyridine Iodochloride complex.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Stoffelbach, Francois published the artcileHow the interplay of different control mechanisms affects the initiator efficiency factor in controlled radical polymerization: An investigation using organometallic Mo^III-based catalysts, Product Details of C5H9IO2, the publication is Journal of Organometallic Chemistry (2007), 692(15), 3133-3143, database is CAplus.

Compound CpMoI₂(iPr₂dad) (iPr₂dad = iPrN=CH-CH=NiPr), obtained by halide exchange from CpMoCl₂(iPr₂dad) and NaI, has been isolated and characterized by EPR spectroscopy, cyclic voltammetry, and X-ray crystallog. Its action as a catalyst in atom transfer radical polymerization (ATRP) and as a spin trap in organometallic radical polymerization (OMRP) of styrene and Me acrylate (MA) monomers has been investigated and compared with that of the dichloro analog. Compound CpMoCl₂(iPr₂dad) catalyzes the ATRP of styrene and MA with low efficiency factors f (as low as 0.37 for MA and Et 2-chloropropionate as initiator), while it irreversibly traps the corresponding growing radical chains under OMRP conditions. On the other hand, compound CpMoI₂(iPr₂dad) has a greater ATRP catalytic activity than the dichloro analog and yields f = 1 for MA and Et 2-iodopropionate as initiator. Under OMRP conditions, it does not irreversibly trap the growing radical chains. This comparison serves to illustrate the general principle that low initiator efficiency factors, sometimes observed in ATRP, may result from the interplay of the ATRP and OMRP mechanisms, when the latter ones involves an irreversible radical trapping process.

Journal of Organometallic Chemistry published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C13H18N2, Product Details of C5H9IO2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Sychev, O. F. published the artcileQuantum chemical calculation of charge transfer and quadrupole interaction constants in complexes, Computed Properties of 6443-90-9, the publication is Izvestiya Akademii Nauk SSSR, Seriya Fizicheskaya (1975), 39(12), 2675-83, database is CAplus.

The electronic structure of SbCl5.L, SnCl4.L2 (L = MeCN and ClCN), and ICl.Py complexes was calculated by using the CNDO/2 method. From the AO population, the quadrupole interaction constants, charge transfer, and charge distribution were estimated A considerable increase in the electron d. on the Cl atoms of the acceptor mols. was observed in all cases. The charge of the central atom of the acceptor was almost constant in the SbCl3.L and ICl.Py complexes but increased in SnCl4.L2. This was explained by an inaccuracy in the Sn calculation parameters. The calculated and exptl. results of the quadrupole interaction constants were in good agreement. The interaction between I and N (and Cl) atoms in the ICl.py complexes is predominantly caused by the σ orbitals.

Izvestiya Akademii Nauk SSSR, Seriya Fizicheskaya published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C5H7NO, Computed Properties of 6443-90-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com