A simple access to N-(un)substituted isoquinolin-1(2H)-ones: Unusual formation of regioisomeric isoquinolin-1(4H)-ones was written by Chary, R. Gangadhara;Dhananjaya, G.;Prasad, K. Vara;Vaishaly, S.;Ganesh, Y. S. S.;Dulla, Balakrishna;Kumar, K. Shiva;Pal, Manojit. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2014.HPLC of Formula: 123278-03-5 This article mentions the following:
A ligand/additive/Pd-free Cu-mediated coupling/cyclization strategy from 2-iodobenzamides and terminal alkynes afforded a practical, one-pot, and general approach towards the synthesis of N-(un)substituted isoquinolin-1(2H)-ones. Both the catalyst and the solvent used are recyclable. The use of the Cu reagent in excess led to the unusual formation of regioisomeric and uncommon isoquinolin-1(4H)-ones. In the experiment, the researchers used many compounds, for example, 3-Chloro-2-iodobenzoic acid (cas: 123278-03-5HPLC of Formula: 123278-03-5).
3-Chloro-2-iodobenzoic acid (cas: 123278-03-5) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.HPLC of Formula: 123278-03-5
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com