Generation and electrophilic substitution reactions of 3-lithio-2-methyleneaziridines was written by Montagne, Cyril;Prevost, Natacha;Shiers, Jason J.;Prie, Gildas;Rahman, Sabitur;Hayes, Jerome F.;Shipman, Michael. And the article was included in Tetrahedron in 2006.Application of 10297-05-9 This article mentions the following:
2-Methyleneaziridinyl anions can be produced by selective deprotonation of the parent aziridine at C-3 using sec-BuLi/TMEDA. Subsequent reaction with a wide variety of electrophiles including MeI, ICH2CH2CH2CH2Cl, PhCH2Br, allyl bromide, Me3SiCl, Bu3SnCl, PhCHO, and Ph2CO provides the corresponding C-3 substituted derivatives in moderate to good yields (43-91%). In the case of homochiral methyleneaziridines bearing an (S)-α-methylbenzyl group on nitrogen, high levels of diastereocontrol (up to 90% de) can be achieved in this lithiation/alkylation sequence. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Application of 10297-05-9).
1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Application of 10297-05-9
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com