Utilizing an Encapsulated Solution of Reagents to Achieve the Four-Component Synthesis of (Benzo)Thiophene Derivatives was written by Shen, Chaoren;Spannenberg, Anke;Auer, Matthias;Wu, Xiao-Feng. And the article was included in Advanced Synthesis & Catalysis in 2017.SDS of cas: 5460-32-2 This article mentions the following:
Herein, a facile method for encapsulating smelly liquid chems. and its application in a modular palladium-catalyzed carbonylative synthesis of multi-substituted thiophenes from terminal alkynes and aryl iodides as well as a palladium-catalyzed carbonylative synthesis of benzothiophene derivatives from aryl iodides and arylboronic acids is demonstrated. Here, the capsule plays a pivotal role in solving the issues on reaction condition incompatibilities and selectivity of multicomponent reactions as well as avoiding deactivation of the catalyst by releasing the reagents when the reaction temperature is raised. It greatly facilitates the development of highly-efficient multicomponent reactions and demonstrates a modular pathway to obtain functionalized mols. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2SDS of cas: 5460-32-2).
4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.SDS of cas: 5460-32-2
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com