Synthesis of 2-[123I and 124I]-iodoisonicotinic acid hydrazide-potential radiotracers for tuberculosis was written by Somawardhana, C. W.;Sajjad, M.;Amartey, J. K.;Lambrecht, R. M.. And the article was included in Applied Radiation and Isotopes in 1991.Safety of 2-Iodopyridine-4-carboxylic acid This article mentions the following:
The radiochem. syntheses of Me 2-[123I]-iodoisonicotinate, 2-[123I]-iodoisonicotinic acid hydrazide (I) and 2-[124I]-iodoisonicotinic acid hydrazide was accomplished. Iodine-123 was incorporated in the Me ester mol. by an exchange reaction in glacial acetic acid. The average efficiency of iodine exchange reaction was (92.6%). This radiotracer was extracted with ether and the solvent was evaporated The residue was re-dissolved in anhydrous ethanol and treated with hydrazine under anhydrous conditions to obtain I. The overall radiochem. yield was 69%. Biodistribution data of both radio-tracers in male Sprague-Dawley rats were collected. This is the first report of SPECT radiopharmaceuticals which may be useful for differential diagnosis of intracranial masses (tuberculoma vs. glioma), and CNS tuberculosis in immunosuppressed subjects. In the experiment, the researchers used many compounds, for example, 2-Iodopyridine-4-carboxylic acid (cas: 58481-10-0Safety of 2-Iodopyridine-4-carboxylic acid).
2-Iodopyridine-4-carboxylic acid (cas: 58481-10-0) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Safety of 2-Iodopyridine-4-carboxylic acid
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com