Studies on antitumor agents. Synthesis of derivatives of retinoic acid was written by Xu, Shiping;Guo, Zongru;Yuan, Zhanliang;Li, Lanmin;Huang, Liang. And the article was included in Yaoxue Xuebao in 1981.Synthetic Route of C7H6INO2 This article mentions the following:
Twenty-seven anti-tumor (no data) retinoic acid amides or esters were prepared by amidation or esterification of retinoic acid (I) with amines, e.g., o-, m– or p-H2NC6H4O2R (R = H, Et) or hydroxy compounds e.g., o-, p-HOC6H4R1 [R1 = CO2Et, CHO, CH(OEt)2], etc., resp. N-[p-(Ethoxycarbonyl)phenyl]retinoamide was the most active and had very low toxicity in mice (no data in original). In the experiment, the researchers used many compounds, for example, 2-Amino-4-iodobenzoic acid (cas: 20776-54-9Synthetic Route of C7H6INO2).
2-Amino-4-iodobenzoic acid (cas: 20776-54-9) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Synthetic Route of C7H6INO2
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com