Month: January 2023

Cope rearrangements in the benzo[b]thiophene series was written by Sura, Tushar P.;MacDowell, Denis W. H.. And the article was included in Journal of Organic Chemistry in 1993.Synthetic Route of C8H5IS This article mentions the following:

The inability to observe Cope rearrangement products at elevated temperatures for di-Et α-allyl-2-naphthalenemalonate and di-Et α-allyl-9-phenanthrenemalonate does not extend to analogous systems resulting from replacement of the aromatic units by 2- and 3-benzo[b]thiophene nuclei. Thermal rearrangement of di-Et α-allyl-3-benzo[b]thiophenemalonate at 215-255°C for 11 h gave the expected Cope rearrangement product di-Et 2-allyl-3-benzo[b]thiophenemalonate (8%) accompanied by trans- and cis-Et 2,3-dihydro-1-(ethoxycarbonyl)-1H-benzo[b]cyclopenta[d]thiopehen-2-acetate in 10% yield 5% yield, resp. The attempted structure verification of 2-allyl-3-benzo[b]thiophenemalonate by an independent route gave di-Et 2-(1-propenyl)-3-benzo[b]thiophenemalonate which when heated at 230-240°C for 18 h gave 1-carbethoxy-2-hydroxy-3-methyldibenzothiophene as a major product. Similar results were observed with 2-substituted analogs of di-Et α-allyl-3-benzo[b]thiophenemalonate, both di-Et 3-allyl-2-benzo[b]thiophenemalonate and Et 1,2-dihydro-3-(ethoxycarbonyl)-3H-benzo[b]cyclopenta[d]thiophene-2-acetate were formed. In the experiment, the researchers used many compounds, for example, 3-Iodobenzo[b]thiophene (cas: 36748-88-6Synthetic Route of C8H5IS).

3-Iodobenzo[b]thiophene (cas: 36748-88-6) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Synthetic Route of C8H5IS

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Palladium-Catalyzed Pyrazole-Directed sp³ C-H Bond Arylation for the Synthesis of β-Phenethylamines was written by Gulia, Nurbey;Daugulis, Olafs. And the article was included in Angewandte Chemie, International Edition in 2017.Product Details of 5460-32-2 This article mentions the following:

We have developed a method for palladium-catalyzed, pyrazole-directed sp³ C-H bond arylation by aryl iodides. The reaction employs a Pd(OAc)₂ catalyst at 5-10 mol % loading and silver(I) oxide as a halide-removal agent, and it proceeds in acetic acid or acetic acid/hexafluoroisopropanol solvent. Ozonolysis of the pyrazole moiety affords pharmaceutically important β-phenethylamines. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Product Details of 5460-32-2).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Product Details of 5460-32-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Catalytic asymmetric synthesis of the alkaloid (+)-myrtine was written by Pizzuti, Maria Gabriella;Minnaard, Adriaan J.;Feringa, Ben L.. And the article was included in Organic & Biomolecular Chemistry in 2008.Computed Properties of C4H8ClI This article mentions the following:

A new protocol for the asym. synthesis of trans-2,6-disubstituted-4-piperidones has been developed using a catalytic enantioselective conjugate addition reaction in combination with a diastereoselective lithiation-substitution sequence; an efficient synthesis of (+)-myrtine (I) has been achieved via this route. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Computed Properties of C4H8ClI).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Computed Properties of C4H8ClI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Simple-structure small molecular acceptors based on a benzodithiophenedione core: synthesis, optoelectronic and photovoltaic properties was written by Zhu, Mengbing;Yu, Xiankang;Huang, Jingwei;Xia, Hao;Zhu, Jianing;Peng, Wenhong;Tan, Hua;Zhu, Weiguo. And the article was included in New Journal of Chemistry in 2021.COA of Formula: C9H4I2OS2 This article mentions the following:

It is crucial to develop high-efficiency simple-structure small mol. acceptors (SMAs) having a shortened synthetic route and lower cost. Herein, two simple SMAs, BDDTTIC and BDDTTIC-4F, with the A-D-A-D-A architecture were primarily synthesized via a simple three-step route in high yields, based on the central acceptor (A′) unit of benzodithiophenedione (BDD), the spacing donor (D) unit of thienothiophene (TT) and the terminal acceptor (A) unit of dicyanomethylene indanone (IC) or its fluorinated analog (IC-4F). The influence of the mol. structure on the photophys., electrochem. and photovoltaic properties was primarily studied. The results show that the fluorine-free BDDTTIC exhibits better solubility and higher LUMO energy levels (-3.81 eV) than the fluorinated BDDTTIC-4F. Moreover, the PM6:BDDTTIC based OSCs show better photovoltaic properties than the PM6:BDDTTIC-4F based OSCs by optimizing the polymer donor material, donor/acceptor ratio and 1-chloronaphthalene additive ratio. An increasing power conversion efficiency of 5.62% with a high open-circuit voltage of 0.95 V was obtained in the optimal PM6:BDDTTIC-based device, which is almost two times higher than that of the optimal PM6:BDDTTIC-4F-based device. This work provides a potential direction to further construct high-efficiency BDD-based SMAs. In the experiment, the researchers used many compounds, for example, Bis(2-iodothiophen-3-yl)methanone (cas: 474416-61-0COA of Formula: C9H4I2OS2).

Bis(2-iodothiophen-3-yl)methanone (cas: 474416-61-0) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.COA of Formula: C9H4I2OS2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

A new and unequivocal method for establishing the position of N-glycosylation of unsymmetrically C-substituted imidazoles was written by Benson, Timothy J.;Robinson, Brian. And the article was included in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) in 1992.COA of Formula: C3H2I2N2 This article mentions the following:

N-Substitution of an unsym. C-substituted imidazole can give rise to a pair of structurally isomeric derivatives and to differentiate between such related compounds can be difficult. Two methods, one spectroscopic and one chem., for ascertaining the orientation of such N-substitutions are described, with particular application to the establishment of the direction of N-ribosidation of a series of halogeno nitroimidazoles. In the experiment, the researchers used many compounds, for example, 4,5-Diiodo-1H-imidazole (cas: 15813-09-9COA of Formula: C3H2I2N2).

4,5-Diiodo-1H-imidazole (cas: 15813-09-9) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.COA of Formula: C3H2I2N2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Unified Strategy for Nickel-Catalyzed C-2 Alkylation of Indoles through Chelation Assistance was written by Soni, Vineeta;Jagtap, Rahul A.;Gonnade, Rajesh G.;Punji, Benudhar. And the article was included in ACS Catalysis in 2016.Category: iodides-buliding-blocks This article mentions the following:

A nickel-catalyzed direct C-2 alkylation of indoles through monodentate-chelation assistance has been described. This reaction proceeds via an unusual strategy by the use of a well-designed and defined (quinolinyl)amido-nickel catalyst, [{κ^N,κ^N,κ^N-Et₂NCH₂C(O)(μ-N)C₉H₆N}Ni(OAc)], providing a solution to the limitations associated with bidentate-chelate auxiliaries. The method allows coupling of indoles with various unactivated primary and secondary alkyl halides with ample substrate scope. This uniquely strategized alkylation proceeded through crucial C-H activation and via an alkyl radical intermediate. The reaction by this approach represents a rare example of Ni-catalyzed monodentate-chelate-assisted C-H functionalization. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Category: iodides-buliding-blocks).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Iodine-Rich Imidazolium Iodate and Periodate Salts: En Route to Single-Based Biocidal Agents was written by He, Chunlin;Hooper, Joseph P.;Shreeve, Jean’ne M.. And the article was included in Inorganic Chemistry in 2016.Category: iodides-buliding-blocks This article mentions the following:

Two classes of iodine-rich salts that consist of iodine-rich cations and iodate (IO₃^–) or periodate (IO₄^–) anions were synthesized. The synthesis of analogous I₃O₈^– salts was more difficult because of poor solubility and hydrolytic instability. All iodine-rich salts were fully characterized by IR, ¹H NMR, and ¹³C NMR spectroscopy as well as elemental analyses. The mol. structures of compounds 15 and 24 were elucidated by X-ray single-crystal diffraction. Addnl., the heats of formation were calculated with Gaussian 03. The detonation properties and biocidal efficiency were calculated and evaluated using CHEETAH 7. In the experiment, the researchers used many compounds, for example, 4,5-Diiodo-1H-imidazole (cas: 15813-09-9Category: iodides-buliding-blocks).

4,5-Diiodo-1H-imidazole (cas: 15813-09-9) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Approach to the synthesis of bryophyte constituents was written by Sagrera, G. J.;Lopez, G. V.;Pandolfi, E. M.;Seoane, G. A.;Eicher, T.. And the article was included in Informacion Tecnologica in 1998.Recommanded Product: 2314-37-6 This article mentions the following:

The synthesis of 2,2-bilunularin (I), a bis(bibenzyl)phenolic compound isolated from bryophytes, is described. The main transformations involve the formation of an aromatic carbon-carbon bond by Ullmann’s reaction and the formation of aliphatic carbon-carbon bonds by Wittig’s reactions. A simple model structure was used to optimize the cyclization conditions to obtain flavanone. Based on the results, biflavanone was synthesized, an advanced intermediate for the preparation of some flavonoids isolated from bryophytes. In the experiment, the researchers used many compounds, for example, 3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6Recommanded Product: 2314-37-6).

3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Recommanded Product: 2314-37-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Aromatic iodination in aqueous solution. A new lease of life for aqueous potassium dichloroiodate was written by Garden, S. J.;Torres, J. C.;de Souza Melo, S. C.;Lima, A. S.;Pinto, A. C.;Lima, E. L. S.. And the article was included in Tetrahedron Letters in 2001.COA of Formula: C3H2I2N2 This article mentions the following:

A re-investigation of the use of aqueous KICl₂ as an iodinating agent for aromatic compounds has found the reagent to be more generally applicable than previously known. The reagent gives excellent yields of iodinated heterocyclic compounds, such as isatin, imidazole, and pyrazole. In the experiment, the researchers used many compounds, for example, 4,5-Diiodo-1H-imidazole (cas: 15813-09-9COA of Formula: C3H2I2N2).

4,5-Diiodo-1H-imidazole (cas: 15813-09-9) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.COA of Formula: C3H2I2N2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Catalytic Enantioselective α-Alkylation of Amides by Unactivated Alkyl Electrophiles was written by Tong, Xiaoyu;Schneck, Felix;Fu, Gregory C.. And the article was included in Journal of the American Chemical Society in 2022.SDS of cas: 10297-05-9 This article mentions the following:

Herein the achievement of this objective, demonstrating that a nickel catalyst could accomplish enantioselective intermol. alkylations of racemic Reformatsky reagents with unactivated electrophiles; the resulting α-alkylated carbonyl compounds could be converted in one addnl. step into a diverse array of ubiquitous families of chiral mols was described. Applying a broad spectrum of mechanistic tools, have gained insight into key intermediates (including the alkylnickel(II) resting state) and elementary steps of the catalytic cycle. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9SDS of cas: 10297-05-9).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.SDS of cas: 10297-05-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com