Month: January 2023

Influence of the Bridging Elements on the Optical Properties of Linked 9,10-Dihydro-9,10-diboraanthracenes was written by Januszewski, Estera;Bolte, Michael;Lerner, Hans-Wolfram;Wagner, Matthias. And the article was included in Organometallics in 2012.Related Products of 3268-21-1 This article mentions the following:

Starting from the monofunctionalized 9,10-dihydro-9,10-diboraanthracene derivatives MesB(C₆H₄)₂BX (X = H, Br), the bridged systems MesB(C₆H₄)₂B-L-B(C₆H₄)₂BMes have been synthesized with L = -C(H):C(H)(p-C₆Me₄)C(H):C(H)- (5), -CC(p-C₆Me₄)CC- (6), and -(p-C₆H₄)(p-C₆Me₄)(p-C₆H₄)- (7). The compounds were characterized by NMR, IR, UV/vis, and fluorescence spectroscopy. The vinyl- and phenylboranes 5 and 7 are pale yellow solids, whereas the alkynylborane 6 possesses a bright yellow color. The emission maxima of 5–7 in toluene are λ_max(em) 477, 460, and 461 nm with quantum yields ϕ_f of 0.02, 0.30, and 0.04, resp. Alkynylborane 6 was the least air- and moisture-sensitive of the three derivatives In the experiment, the researchers used many compounds, for example, 1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1Related Products of 3268-21-1).

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Related Products of 3268-21-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Crystal Growth, Structure, and Polymorphic Behavior of an Ionic Liquid: Phthalate Derivative of N-Butyl,N-methylimidazolium Hexafluorophosphate was written by Brandel, Clement;Gbabode, Gabin;Cartigny, Yohann;Martin, Claudette;Gouhier, Geraldine;Petit, Samuel;Coquerel, Gerard. And the article was included in Chemistry of Materials in 2014.Reference of 10297-05-9 This article mentions the following:

After the multistep synthesis of an original imidazolium hexafluorophosphate ionic liquid, [pbmim][PF₆], two polymorphic forms were isolated from methanolic solution and characterized by XRPD, DSC, and Raman spectroscopy. Stable Form A (mp 90.3 °C) was obtained by conventional crystallization at a moderate cooling rate (<10 K/min), whereas metastable Form B (mp 83.2 °C) was spontaneously produced from a liquid-liquid demixing (oiling out) when a faster cooling rate (>10 K/min) was applied. Structural analyses carried out by using single-crystal (Form A) and powder (Form B) X-ray diffraction revealed a rotational disorder of anionic octahedrons and, more interestingly, large conformational differences between cationic moieties caused by their mol. flexibility. Crystal growth of [pbmim][PF₆] (Form A) in methanol often leads to numerous crystal defects and revealed that most of them consist of liquid inclusions. The supersaturation ratio (β) appeared to be the predominant factor influencing the crystal growth behavior under isothermal and stagnant conditions. At low β values, a morphol. transition from rod-shaped crystals to platelets was observed, presumably caused by a change in the growth mechanism of specific faces. Using high β values promotes either the formation of microscopic (<5 μm) liquid inclusions that become easily detectable upon heating or the appearance of macroscopic inclusions with an hourglass shape. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Reference of 10297-05-9).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Reference of 10297-05-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Design, synthesis and preliminary biological evaluation of acridine compounds as potential agents for a combined targeted chemo-radionuclide therapy approach to melanoma was written by Desbois, Nicolas;Gardette, Maryline;Papon, Janine;Labarre, Pierre;Maisonial, Aurelie;Auzeloux, Philippe;Lartigue, Claire;Bouchon, Bernadette;Debiton, Eric;Blache, Yves;Chavignon, Olivier;Teulade, Jean-Claude;Maublant, Jean;Madelmont, Jean-Claude;Moins, Nicole;Chezal, Jean-Michel. And the article was included in Bioorganic & Medicinal Chemistry in 2008.Electric Literature of C7H6INO2 This article mentions the following:

Various iodo-acridone and acridine carboxamides have been prepared and evaluated as agents for targeted radionuclide and/or chemotherapy for melanoma, due to their structural similarity to benzamides which are known to possess specific affinity for melanin. Three of these carboxamides selected for their in vitro cytotoxic properties were radioiodinated with [¹²⁵I]NaI at high specific activity. Biodistribution studies carried out in B16F0 murine melanoma tumor-bearing mice highlighted that acridone 8f and acridine 9d, presented high, long-lasting tumor concentrations together with an in vivo kinetic profile favorable to application in targeted radionuclide therapy. In the experiment, the researchers used many compounds, for example, 2-Amino-4-iodobenzoic acid (cas: 20776-54-9Electric Literature of C7H6INO2).

2-Amino-4-iodobenzoic acid (cas: 20776-54-9) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Electric Literature of C7H6INO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The carboxyl group. Infrared absorption and ionization was written by Peltier, Daniel;Pichevin, Annick. And the article was included in Bulletin de la Societe Chimique de France in 1960.COA of Formula: C8H7IO2 This article mentions the following:

PK, ν_OH(monomeric), and ν_C:O (monomeric and dimeric) values of 17 substituted benzoic, 34 o-toluic, 17 m-toluic, and 12 p-toluic acids, as well as the ν_C:O values of 55 Me and Et esters were tabulated. For all the acids except the 6-substituted o-toluic acids (6-NO₂, I, Br, Cl, OH, NH₂), ν_OH (cm.^-1) = 3498 + 9pK. The ν_C:O (monomeric) of the o-OH and o-NH₂ acids were on the average 55 cm.^-1 lower and those of nonchelated, 6-substituted o-toluic acids were approx. 5 cm.^-1 higher than calculated from the appropriate equations (CA 53, 17954e). For acids free of chelation and steric effects, ν_OH = 5,028 – 0.857 ν_C:O (monomeric) (cm.^-1). For 3-, 4-, and 5-substituted o-toluic acids, ν_OH = 5053 – 0.874 ν_C:O. The carbonyl frequencies of the Et esters were approx. 5 cm.^-1 lower than those of the corresponding Me esters. These results are explained by electronic effects of H or alkyl group on the carbonyl group. 6-HO(or H₂N)-2-MeC₆H₃CO₂Me exhibited 2 carbonyl frequencies related to chelated and nonchelated forms. Similar data were presented for 2,3- (I), 2,4-, and 2,6-(MeO)MeC₆H₃CO₂H, and o-MeOC₆H₄CO₂H. The dimeric carbonyl absorptions were weak, the ν_OH were lower, and the ν_C:O were higher, based on the relations with pK, than expected for nonchelated acids. I was exceptional, as it gave a strong dimeric carbonyl absorption. In the experiment, the researchers used many compounds, for example, 3-Iodo-2-methylbenzoic acid (cas: 133232-56-1COA of Formula: C8H7IO2).

3-Iodo-2-methylbenzoic acid (cas: 133232-56-1) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.COA of Formula: C8H7IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Examination of the New α-(2’Z-Fluoro)vinyl Trigger with Lysine Decarboxylase: The Absolute Stereochemistry Dictates the Reaction Course was written by Karukurichi, Kannan R.;De la Salud-Bea, Roberto;Jahng, Wan Jin;Berkowitz, David B.. And the article was included in Journal of the American Chemical Society in 2007.Electric Literature of C4H8ClI This article mentions the following:

The first examination of a terminal α-fluorovinyl trigger in an amino acid decarboxylase (LDC) active site is reported. To investigate the enantiospecificity of inactivation with this new AADC trigger, an enantioselective synthesis of L-α-(2’Z-fluoro)vinyllysine and its D-antipode has been developed. Control of stereochem. is achieved through introduction of the amino acid side chain via alkylation of a chiral vinylglycine-derived dienolate. Facial selectivity is conferred by a trans-2′(β-naphthyl)-2′-propylcyclohexyl ester auxiliary, available in both antipodal forms (Comins protocol). The alkylation employs a new electrophile, N-p-methoxybenzyl-N-(2′-trimethylsilylethanesulfonyl)-4-iodobutylamine, for convergent installation of the lysine side chain. Vinyl to 2′-fluorovinyl interconversion then provides L– and D-α-(2’Z-fluoro)vinyllysine in 97-99% ee, as demonstrated by chiral HPLC. Both time-dependent enzyme kinetics and ¹⁹F NMR reveal striking differences in the behavior of these two antipodes in the lysine decarboxylase active site. The L-antipode displays time dependent inactivation (t_1/2 = 3±1 min; K_I = 86±22 μM), whereas the D-antipode behaves as a substrate, being completely turned over to α-(2’Z-fluoro)vinylcadaverine. Titration of LDC with varying amounts of L-α-(2’Z-fluoro)vinyllysine provides an estimate of 20±3 for the partition ratio for this antipode. ¹⁹F NMR provides a more detailed account of the inactivation with the L-antipode, revealing that 1 in 3.4 turnovers of this mechanism-based inhibitor results in errant protonation (required by design), with 1 in 5 errant protonation events leading to LDC inactivation. This gives an overall partition ratio of 16±2. Fluoride-selective electrode measurements are in agreement with ¹⁹F NMR estimates of [fluoride] released. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Electric Literature of C4H8ClI).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Electric Literature of C4H8ClI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Palladium-Catalyzed Site-Selective Benzocylization of Aromatic Acids with o-Fluoro-Substituted Diaryliodonium Salts toward 3,4-Benzocoumarins was written by Pan, Cheng;Wang, Limin;Han, Jianwei. And the article was included in Organic Letters in 2020.Recommanded Product: 1-Fluoro-2-iodo-4-methylbenzene This article mentions the following:

By using 2-fluoro-substituted diaryliodonium salts, a novel benzocylization has been accomplished for the synthesis of 3,4-benzocoumarin derivatives via a cascade of ortho-arylation and defluorination in the presence of palladium catalysts. The reaction exhibits a broad compatibility of readily available aromatic acids with an excellent level of site-selectivity. Mechanistic investigations revealed a unique reactivity of carboxylic acid directed arylation by followed nucleophilic substitution of aromatic fluoride in the present system. In the experiment, the researchers used many compounds, for example, 1-Fluoro-2-iodo-4-methylbenzene (cas: 452-82-4Recommanded Product: 1-Fluoro-2-iodo-4-methylbenzene).

1-Fluoro-2-iodo-4-methylbenzene (cas: 452-82-4) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Recommanded Product: 1-Fluoro-2-iodo-4-methylbenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Eosin-Mediated Alkylsulfonyl Cyanation of Olefins was written by Pirenne, Vincent;Kurtay, Gulbin;Voci, Silvia;Bouffier, Laurent;Sojic, Neso;Robert, Frederic;Bassani, Dario M.;Landais, Yannick. And the article was included in Organic Letters in 2018.Category: iodides-buliding-blocks This article mentions the following:

Eosin-Y (EY)-mediated alkylsulfonyl cyanation of olefins was shown to afford alkylsulfonyl nitriles in good yields. On the basis of transient absorption spectroscopy, the reaction was shown to proceed via photoinduced electron transfer from ³EY* to an O-cyanated derivative of the photocatalyst, formed in situ, with generation of the corresponding sulfinate that is oxidized by EY^â€?+ into a sulfonyl radical. Addition of the latter on the olefin, followed by a radical cyano group transfer, then furnished the nitrile along with a RSO₂ radical sustaining the radical chain. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Category: iodides-buliding-blocks).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthesis and Characterization of Bridged Bithiophene-Based Conjugated Polymers for Photovoltaic Applications: Acceptor Strength and Ternary Blends was written by Chen, Chiu-Hsiang;Hsieh, Chao-Hsiang;Dubosc, Martin;Cheng, Yen-Ju;Hsu, Chain-Shu. And the article was included in Macromolecules (Washington, DC, United States) in 2010.Safety of Bis(2-iodothiophen-3-yl)methanone This article mentions the following:

Six of three-component donor-acceptor random copolymers P1-P6, symbolized as (thiophene donor)_m-(thiophene acceptor)_n, were rationally designed and successfully synthesized by the palladium-catalyzed Stille coupling. The 4H-cyclopenta[2,1-b:3,4-b’]dithiophene (CPDT) unit serves as the donor for P1-P4, while the benzothiadiazole (BT), quinoxaline (QU), dithienoquinoxaline, and thienopyrazine (TP) units are used as the acceptor for P1, P2, P3, and P4, resp. P5 and P6 are structurally analogous to P1 and P2 except for using the dithieno[3,2-b:2′,3′-d]silole (DTS) unit as the donor. Because the band gap lowering ability of the acceptor units in the polymer is in the order TP > BT > QU presumably due to the quinoid form population in the polymers, the optical band gaps can be well adjusted to be 1.2, 1.6, and 1.8 eV for P4, P1, and P2, resp. It is found that the two bridged bithiophene units, CPDT and DTS, have similar steric and electronic effects on the P1 and P5 as well as P2 and P6, resp., leading to comparable intrinsic properties and device performances. Bulk heterojunction photovoltaic cells based on ITO/PEDOT:PSS/polymer:PC₇₁BM/Ca/Al configuration were fabricated and characterized. Although P4 exhibits the lowest optical band gap, broadest absorption spectrum, and highest mobility, the too low-lying LUMO level hinders the efficient exciton dissociation, resulting in a low PCE of 0.7%. Compared with poly[2,6-(4,4-bis(2-ethylhexyl)-4H-cyclopenta[2,1-b;3,4-b’]dithiophene)-alt-4,7-(2,1,3-benzothiadiazole)] (PCPDTBT), random copolymer P1 shows more blue-shifted, broader absorption spectrum, comparable mobility, and a higher PCE of 2.0%. In view of the fact that P1 shows a higher band gap with strong absorption in visible region, while PCPDTBT has a lower band gap to mainly absorb NIR light, a BHJ device with the active layer containing ternary blend of PCPDTBT/P1/PC₇₁BM was investigated and achieved an enhanced PCE of 2.5%, which outperforms the devices based on the binary blending systems of PCPDTBT/PC₇₁BM (PCE = 1.4%) or P1/PC₇₁BM (PCE = 2.0%) under the identical conditions. Such an improvement is ascribed to the complementary absorption and compatible structure of P1 and PCPDTBT polymers. In the experiment, the researchers used many compounds, for example, Bis(2-iodothiophen-3-yl)methanone (cas: 474416-61-0Safety of Bis(2-iodothiophen-3-yl)methanone).

Bis(2-iodothiophen-3-yl)methanone (cas: 474416-61-0) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Safety of Bis(2-iodothiophen-3-yl)methanone

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Design and synthesis of azaindole heterocycle decorated new scaffold in fluorometric sensing of F^– and H₂PO₄^– was written by Ghosh, Kumaresh;Ali, Sk. Sarfaraj;Joardar, Soumen. And the article was included in Journal of Heterocyclic Chemistry in 2020.Product Details of 1227270-32-7 This article mentions the following:

7-Azaindole has been used in designing new mol. structure 1 on enediyne spacer for its application in anion sensing. New structure 1 has been established as efficient fluorescent sensor of H₂PO₄^– and F^– ions in CH₃CN containing 1% DMSO. While in presence of H₂PO₄^– the emission at 418 nm is decreased to the significant extent in nonratiometric fashion, a ratiometric response in presence of F^– is noted with a sharp isoemissive point and two anions are effectively distinguished over a series of other anions tested. A similar study on model compound 2 with indole motifs is done to prove the pivotal role of extra ring nitrogen in azaindole of 1 in the binding process. In the experiment, the researchers used many compounds, for example, 2-Iodo-1H-pyrrolo[2,3-b]pyridine (cas: 1227270-32-7Product Details of 1227270-32-7).

2-Iodo-1H-pyrrolo[2,3-b]pyridine (cas: 1227270-32-7) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Product Details of 1227270-32-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

One-Pot Synthesis of Trifluoromethylated Quinazolin-4(3H)-ones with Trifluoroacetic Acid as CF₃ Source was written by Almeida, Sofia;Marti, Roger;Vanoli, Ennio;Abele, Stefan;Tortoioli, Simone. And the article was included in Journal of Organic Chemistry in 2018.Electric Literature of C7H6INO2 This article mentions the following:

A novel and convenient one-pot sequential cascade method for the preparation of 2-trifluoromethylquinazolin-4(3H)-ones, e.g., I, is described. Trifluoroacetic acid (TFA) was employed as inexpensive and readily available CF₃ source, which in the presence of T3P was condensed with a variety of anthranilic acids and amines to provide the products in up to 75% yield. The protocol was proved to be robust on 80 g scale, and the synthetic versatility of the prepared quinazolinon-4-ones was demonstrated by derivatization to further useful building blocks. In the experiment, the researchers used many compounds, for example, 2-Amino-4-iodobenzoic acid (cas: 20776-54-9Electric Literature of C7H6INO2).

2-Amino-4-iodobenzoic acid (cas: 20776-54-9) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Electric Literature of C7H6INO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com