Month: January 2023

Nickel-Catalyzed Cross-Coupling of Potassium Aryl- and Heteroaryltrifluoroborates with Unactivated Alkyl Halides was written by Molander, Gary A.;Argintaru, O. Andreea;Aron, Ioana;Dreher, Spencer D.. And the article was included in Organic Letters in 2010.Formula: C4H8ClI This article mentions the following:

A method for the cross-coupling of alkyl electrophiles with various potassium aryl- and heteroaryltrifluoroborates has been developed. Nearly stoichiometric amounts of organoboron species could be employed to cross-couple a large variety of challenging heteroaryl nucleophiles. Several functional groups were tolerated on both the electrophilic and the nucleophilic partners. Chemoselective reactivity of C(sp³)-Br bonds in the presence of C(sp²)-Br bonds was achieved. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Formula: C4H8ClI).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Formula: C4H8ClI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthesis of 1,2,4-Triazoles, N-Fused 1,2,4-Triazoles and 1,2,4-Oxadiazoles via Molybdenum Hexacarbonyl-Mediated Carbonylation of Aryl Iodides was written by Nakka, Mangarao;Tadikonda, Ramu;Nakka, Srinivas;Vidavalur, Siddaiah. And the article was included in Advanced Synthesis & Catalysis in 2016.Reference of 5460-32-2 This article mentions the following:

A convenient and efficient protocol was developed for the synthesis of 1,2,4-triazoles, N-fused 1,2,4-triazoles and 1,2,4-oxadiazoles from aryl iodides and amidrazones, 2-hydrazinylpyridine, 2-hydrazinylpyrazine or amidoximes using molybdenum hexacarbonyl which acts as a convenient and reliable solid source of carbon monoxide. This procedure provided an easy access to a library of 1,2,4-triazole, N-fused 1,2,4-triazole and 1,2,4-oxadiazole derivatives in fair to good yields without the need of gaseous carbon monoxide and palladium catalysts. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Reference of 5460-32-2).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Reference of 5460-32-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Copper-catalyzed synthesis of benzo[d][1,3]dioxin-4-ones via tandem Ar-halogen bond hydroxylation and dichloromethane-based double Williamson etherification was written by Liu, Yunyun;Huang, Meiying;Wei, Li. And the article was included in New Journal of Chemistry in 2017.Recommanded Product: 13420-63-8 This article mentions the following:

The reactions of o-halobenzoic acids, dichloromethane and potassium hydroxide providing benzo[d][1,3]dioxin-4-ones was reported via the catalysis of Cu(OAc)₂. Tandem Ar-X (X = I, Br) bond hydroxylation and double Williamson etherification on dichloromethane were involved during the construction of the target products. In the experiment, the researchers used many compounds, for example, 2-Chloro-6-iodobenzoic acid (cas: 13420-63-8Recommanded Product: 13420-63-8).

2-Chloro-6-iodobenzoic acid (cas: 13420-63-8) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Recommanded Product: 13420-63-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

One-Pot Synthesis and Conformational Analysis of Six-Membered Cyclic Iodonium Salts was written by Caspers, Lucien D.;Spils, Julian;Damrath, Mattis;Lork, Enno;Nachtsheim, Boris J.. And the article was included in Journal of Organic Chemistry in 2020.Name: (5-Fluoro-2-iodophenyl)methanol This article mentions the following:

Two one-pot procedures for the construction of carbon-bridged diaryliodonium triflates and tetrafluoroborates, e.g., I, are described. Strong Bronsted acids enable the effective Friedel-Crafts alkylation with diversely substituted o-iodobenzyl alc. derivatives, providing diphenylmethane scaffolds, which are subsequently oxidized and cyclized to the corresponding dibenzo[b,e]iodininium salts. Based on NMR investigations and d. functional theory (DFT) calculations, we could verify the so-far-undescribed existence of two stable isomers in cyclic iodonium salts substituted with aliphatic side chains in the carbon bridge. In the experiment, the researchers used many compounds, for example, (5-Fluoro-2-iodophenyl)methanol (cas: 877264-43-2Name: (5-Fluoro-2-iodophenyl)methanol).

(5-Fluoro-2-iodophenyl)methanol (cas: 877264-43-2) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Name: (5-Fluoro-2-iodophenyl)methanol

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Self-Assembly of M₃₀L₆₀ Icosidodecahedron was written by Fujita, Daishi;Ueda, Yoshihiro;Sato, Sota;Yokoyama, Hiroyuki;Mizuno, Nobuhiro;Kumasaka, Takashi;Fujita, Makoto. And the article was included in Chem in 2016.Synthetic Route of C10H12I2 This article mentions the following:

Self-assembly is invaluable in the construction of giant mol. structures via a bottom-up approach. Although living organisms naturally make the most use of self-assembly and freely handle the mechanism at will, scientists are still far behind the level of nature. Inspired by the elegant structures of virus capsids, the authors have previously constructed roughly spherical giant metal complexes with the symmetry of an octahedron, cuboctahedron, and rhombicuboctahedron M₆L₁₂, M₁₂L₂₄, and M₂₄L₄₈, resp. Here, the authors report the 1st successful synthesis of an M₃₀L₆₀ mol. icosidodecahedron that consists of âˆ?00 components: 30 Pd(II) ions and 60 (2,5-bis(4-pyridyl-1,4-tetramethylphenylene)thiophene) ligands that assemble into the largest well-defined spherical macromol. to date (diameter of âˆ?.2 nm). Tuning the flexibility of the ligand was the key for successful self-assembly. A highly complex but sym. organized structure was identified through x-ray crystallog. anal. The interior space of the mol. complex is large enough (157,000 ų) to enclose proteins. In the experiment, the researchers used many compounds, for example, 1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1Synthetic Route of C10H12I2).

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Synthetic Route of C10H12I2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic chalcones, flavanones, and flavones as antitumoral agents: Biological evaluation and structure-activity relationships was written by Cabrera, Mauricio;Simoens, Macarena;Falchi, Gabriela;Lavaggi, M. Laura;Piro, Oscar E.;Castellano, Eduardo E.;Vidal, Anabel;Azqueta, Amaia;Monge, Antonio;Lopez de Cerain, Adela;Sagrera, Gabriel;Seoane, Gustavo;Cerecetto, Hugo;Gonzalez, Mercedes. And the article was included in Bioorganic & Medicinal Chemistry in 2007.SDS of cas: 2314-37-6 This article mentions the following:

A series of synthetic chalcones, flavanones, and flavones has been synthesized and evaluated for antitumor activity against the human kidney carcinoma cells TK-10, human mammary adenocarcinoma cells MCF-7 (estrogen receptor-pos.), and human colon adenocarcinoma cells HT-29. The most active series is the chalcone ones with the best results against TK-10 and HT-29 cells. Fourteen out of 53 analyzed compounds resulted very active against at least two of the studied tumoral cells. Alk. single cell gel electrophoresis, comet assay, was performed as a study of the chromosomal aberrations promoted by the compounds on normal cells. Four active and two inactive chalcones were studied in the comet assay against normal human kidney cells (HK-2). A structure-activity relationship anal. of these compounds was performed and for 4- and 3,4-disubstituted derivatives a quant. correlation was obtained in the case of anti-HT-29 activity. In the experiment, the researchers used many compounds, for example, 3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6SDS of cas: 2314-37-6).

3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.SDS of cas: 2314-37-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Iodination of aromatic compounds by N-iodosuccinimide in organic solvents in the presence of H₂SO₄ was written by Chaikovski, V. K.;Filimonov, V. D.;Skorokhodov, V. I.. And the article was included in Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya in 2002.HPLC of Formula: 3268-21-1 This article mentions the following:

N-iodosuccinimide in organic solvents in the presence of small amounts of H₂SO₄ easily iodinates alkylbenzenes, arylamines, phenols and some polycyclic hydrocarbons with high yields of products at 0-20°. In the experiment, the researchers used many compounds, for example, 1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1HPLC of Formula: 3268-21-1).

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.HPLC of Formula: 3268-21-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Stereo-retentive Intramolecular Glycosyl Cross-Coupling: Development, Scope, and Kinetic Isotope Effect Study was written by Yi, Duk;Zhu, Feng;Walczak, Maciej A.. And the article was included in Organic Letters in 2018.HPLC of Formula: 13420-63-8 This article mentions the following:

A series of cyclic C-glycosides were synthesized using the palladium-catalyzed stereo-retentive intramol. glycosylation of aryl iodides by employing a bulky phosphine ligand. A variety of functional groups are tolerated in the reaction, and enantio-enriched anomeric nucleophiles could be coupled without erosion of optical purity. This study offers a unified method to access both cis- and trans-fused rings by capitalizing on the stereo-retentive nature of the Stille reaction. In addition, competition experiments for intermol. and intramol. cross-couplings revealed secondary KIEs of 1.43 and 0.81, resp., suggesting a profoundly different steric congestion at the transition state. In the experiment, the researchers used many compounds, for example, 2-Chloro-6-iodobenzoic acid (cas: 13420-63-8HPLC of Formula: 13420-63-8).

2-Chloro-6-iodobenzoic acid (cas: 13420-63-8) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.HPLC of Formula: 13420-63-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Copper-catalyzed trifluoromethylation of aryl iodides with potassium (trifluoromethyl)trimethoxyborate was written by Knauber, Thomas;Arikan, Fatih;Roeschenthaler, Gerd-Volker;Goossen, Lukas J.. And the article was included in Chemistry – A European Journal in 2011.HPLC of Formula: 77350-52-8 This article mentions the following:

Potassium (trifluoromethyl)trimethoxyborate is introduced as a new source of CF₃ nucleophiles in copper-catalyzed trifluoromethylation reactions. The crystalline salt is stable on storage, easy to handle, and can be obtained in near-quant. yields simply by mixing B(OMe)₃, CF₃SiMe₃, and KF. The trifluoromethylation reagent allows the conversion of various aryl iodides into the corresponding benzotrifluorides in high yields under mild, base-free conditions in the presence of catalytic quantities of a Cu^I/1,10-phenanthroline complex. In the experiment, the researchers used many compounds, for example, N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8HPLC of Formula: 77350-52-8).

N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.HPLC of Formula: 77350-52-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthesis and Antimicrobial Activity of δ-Viniferin Analogues and Isosteres was written by Mattio, Luce Micaela;Pinna, Cecilia;Catinella, Giorgia;Musso, Loana;Pedersen, Kasandra Juliet;Krogfelt, Karen Angeliki;Dallavalle, Sabrina;Pinto, Andrea. And the article was included in Molecules in 2021.Application of 207115-22-8 This article mentions the following:

The construction of stilbenoid-derived 2,3-diaryl-5-substituted benzofurans, which allowed to prepare a focused collection of dehydro-δ-viniferin analogs. was reported. The antimicrobial activity of the synthesized compounds was evaluated against S. aureus ATCC29213. The simplified analog 5,5′-(2-(4-hydroxyphenyl)benzofuran-3,5-diyl)bis(benzene-1,3-diol), obtained in three steps from 4-bromo-2-iodophenol (63% overall yield), emerged as a promising candidate for further investigation (MIC = 4μg/mL). In the experiment, the researchers used many compounds, for example, 4-Bromo-2-iodophenol (cas: 207115-22-8Application of 207115-22-8).

4-Bromo-2-iodophenol (cas: 207115-22-8) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Application of 207115-22-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com