Month: January 2023

Development of a one-pot sequential Sonogashira coupling for the synthesis of benzofurans was written by Csekei, Marton;Novak, Zoltan;Kotschy, Andras. And the article was included in Tetrahedron in 2008.Name: 4-Bromo-2-iodophenol This article mentions the following:

An efficient one-pot protocol was developed for the construction of the benzofuran system from aryl halides and protected iodophenols using carbinol-based acetylene sources. The sequence includes alternating palladium-catalyzed Sonogashira couplings and deprotection steps concluded by a ring closure. The developed one-pot procedure was compared with the stepwise approach and its efficiency was also demonstrated by the total synthesis of vignafuran, a benzofuran natural product. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-iodophenol (cas: 207115-22-8Name: 4-Bromo-2-iodophenol).

4-Bromo-2-iodophenol (cas: 207115-22-8) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Name: 4-Bromo-2-iodophenol

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthesis and evaluation of FAK inhibitors with a 5-fluoro-7H-pyrrolo[2,3-d]pyrimidine scaffold as anti-hepatocellular carcinoma agents was written by Tan, Hanyi;Liu, Yue;Gong, Chaochao;Zhang, Jiawei;Huang, Jian;Zhang, Qian. And the article was included in European Journal of Medicinal Chemistry in 2021.HPLC of Formula: 1012785-51-1 This article mentions the following:

Focal adhesion kinase (FAK) is a ubiquitous intracellular non-receptor tyrosine kinase, which is involved in multiple cellular functions, including cell adhesion, migration, invasion, survival, and angiogenesis. In this study, a series of 7H-pyrrolo[2,3-d]pyrimidines were designed and synthesized according to the E-pharmacophores generated by docking a library of 667 fragments into the ATP pocket of the co-crystal complex of FAK and PF-562271 (PDB ID: 3BZ3). The 5-fluoro-7H-pyrrolo[2,3-d]pyrimidine derivatives demonstrated excellent activity against FAK and the cell lines SMMC7721 and YY8103. 2-((2-((3-(Acetamidomethyl)phenyl)amino)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-methylbenzamide (I) was selected for further bioactivity evaluations in vivo, including preliminary pharmacokinetic profiling in rats and toxicity assays in mice, and tumor growth inhibition studies in a xenograft tumor model. The results showed that I did not affect the body weight gain of the animals up to a dose of 200 mg/kg, and significantly inhibited tumor growth with a tumor growth inhibition rate of 78.6% compared with the neg. control group. Furthermore, phosphoantibody array analyses of a sample of the tumor suggested that I inhibited the malignant proliferation of hepatocellular carcinoma (HCC) cells through decreasing the phosphorylation in the FAK cascade. In the experiment, the researchers used many compounds, for example, 2,4-Dichloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine (cas: 1012785-51-1HPLC of Formula: 1012785-51-1).

2,4-Dichloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine (cas: 1012785-51-1) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.HPLC of Formula: 1012785-51-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Development of a Palladium-Catalyzed Carbonylative Coupling Strategy to 1,4-Diketones was written by Yin, Hongfei;Nielsen, Dennis U.;Johansen, Mette K.;Lindhardt, Anders T.;Skrydstrup, Troels. And the article was included in ACS Catalysis in 2016.COA of Formula: C8H9IO2 This article mentions the following:

We report on a three-component palladium-catalyzed coupling strategy for accessing a wide range of 1,4-diketones, which represent important precursors to heterocycles. Our method relies on a carbonylative Heck reaction employing substituted allylic alcs., aryl iodides, and carbon monoxide. The reaction conditions are mild and do not require high CO pressure, and a wide functional group tolerance is revealed, providing the desired 1,4-diketones in moderate to good yields. Furthermore, the methodol. is adaptable to the selective installment of ¹³C-carbon isotopes at either one or both of the carbonyl positions. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2COA of Formula: C8H9IO2).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.COA of Formula: C8H9IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Selective angiotensin II AT₂ receptor agonists: Benzamide structure-activity relationships was written by Wallinder, Charlotta;Botros, Milad;Rosenstroem, Ulrika;Guimond, Marie-Odile;Beaudry, Helene;Nyberg, Fred;Gallo-Payet, Nicole;Hallberg, Anders;Alterman, Mathias. And the article was included in Bioorganic & Medicinal Chemistry in 2008.Recommanded Product: N,N-Diethyl-4-iodobenzamide This article mentions the following:

In the investigation of the structure-activity relationship of nonpeptide AT₂ receptor agonists, a series of substituted benzamide analogs of the selective nonpeptide AT₂ receptor agonist M024 have been synthesized. In a second series, the biphenyl scaffold was compared to the thienylphenyl scaffold and the impact of the iso-Bu substituent and its position on AT₁/AT₂ receptor selectivity was also investigated. Both series included several compounds with high affinity and selectivity for the AT₂ receptor. Three of the compounds were also proven to function as agonists at the AT₂ receptor, as deduced from a neurite outgrowth assay, conducted in NG108-15 cells. In the experiment, the researchers used many compounds, for example, N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8Recommanded Product: N,N-Diethyl-4-iodobenzamide).

N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Recommanded Product: N,N-Diethyl-4-iodobenzamide

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electron transfer mechanism for periodic acid oxidation of aromatic substrates was written by Bhatt, M. V.;Hosur, B. M.. And the article was included in Indian Journal of Chemistry in 1986.Quality Control of 3-Iodo-4-methoxybenzaldehyde This article mentions the following:

Oxidation of phenolic ethers, e.g. I (R = Me, R¹ = H) with 1 equiv of H₅IO₆ gave the iodinated product I (R = Me, R¹ = iodo). Use of 2 equiv of oxidant gave I (R = CHO, R¹ = iodo) in which the side chain was oxidized. Oxidation of binaphthyl II with either H₅IO₆ or ceric ammonium nitrate in MeOH gave the same cyclized product III. ESR signals were found for the H₅IO₆ oxidation of 11 aromatic substrates. The ESR data and addnl. chem. evidence suggest a radical cation mechanism for the oxidation In the experiment, the researchers used many compounds, for example, 3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6Quality Control of 3-Iodo-4-methoxybenzaldehyde).

3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Quality Control of 3-Iodo-4-methoxybenzaldehyde

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Polyimides derived from 2,2′-bis(trifluoromethyl)-4,4′-diaminobiphenyl. 2. Synthesis and characterization of polyimides prepared from fluorinated benzenetetracarboxylic dianhydrides was written by Matsuura, Tohru;Ishizawa, Maki;Hasuda, Yoshinori;Nishi, Shiro. And the article was included in Macromolecules in 1992.Product Details of 3268-21-1 This article mentions the following:

Fluorinated rigid-rod polyimides are prepared by the polymerization of 2,2′-bis(trifluoromethyl)-4,4′-diaminobiphenyl (I) with 1,4-bis(trifluoromethyl)-2,3,5,6-benzenetetracarboxylic dianhydride (II), 1-(trifluoromethyl)-2,3,5,6-benzenetetracarboxylic dianhydride, or pyromellitic dianhydride (III). The dielec. constant, refractive index, and water absorption of the copolymers decrease with an increasing number of CF₃ side chains. The I–II polyimide, which has the highest F content, has the lowest dielec. constant of 2.6 at 1 MHz, the lowest refractive index of 1.490 at 589.3 nm, and the lowest water absorption of 0.38%. The coefficient of thermal expansion (CTE) of the copolymers increases with an increasing number of CF₃ side chains. I–III polyimide has a neg. CTE of -5 × 10^-6 °C^-1 by thermomech. anal. and a high polymer decomposition temperature of 613° measured for a 10% weight loss in a N atm. by TG. In the experiment, the researchers used many compounds, for example, 1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1Product Details of 3268-21-1).

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Product Details of 3268-21-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Pd-catalyzed dehydrogenative annulation approach for the efficient synthesis of phenanthridinones was written by Li, Xinyao;Pan, Jun;Song, Song;Jiao, Ning. And the article was included in Chemical Science in 2016.SDS of cas: 36748-88-6 This article mentions the following:

A novel Pd-catalyzed intermol. dehydrogenative annulation of aryl iodides and aryl carbamic chlorides for the efficient synthesis of phenanthridinone derivatives was developed. Simple aryl iodides and carbamic chlorides readily made from various anilines, a broad substrate scope with hetero/polycycles, as well as high-value products, made this direct dehydrogenative annulation approach very practical and attractive. In the experiment, the researchers used many compounds, for example, 3-Iodobenzo[b]thiophene (cas: 36748-88-6SDS of cas: 36748-88-6).

3-Iodobenzo[b]thiophene (cas: 36748-88-6) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.SDS of cas: 36748-88-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Utilizing an Encapsulated Solution of Reagents to Achieve the Four-Component Synthesis of (Benzo)Thiophene Derivatives was written by Shen, Chaoren;Spannenberg, Anke;Auer, Matthias;Wu, Xiao-Feng. And the article was included in Advanced Synthesis & Catalysis in 2017.SDS of cas: 5460-32-2 This article mentions the following:

Herein, a facile method for encapsulating smelly liquid chems. and its application in a modular palladium-catalyzed carbonylative synthesis of multi-substituted thiophenes from terminal alkynes and aryl iodides as well as a palladium-catalyzed carbonylative synthesis of benzothiophene derivatives from aryl iodides and arylboronic acids is demonstrated. Here, the capsule plays a pivotal role in solving the issues on reaction condition incompatibilities and selectivity of multicomponent reactions as well as avoiding deactivation of the catalyst by releasing the reagents when the reaction temperature is raised. It greatly facilitates the development of highly-efficient multicomponent reactions and demonstrates a modular pathway to obtain functionalized mols. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2SDS of cas: 5460-32-2).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.SDS of cas: 5460-32-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthesis of reversible PAD4 inhibitors via copper-catalyzed C-H arylation of benzimidazole was written by Guo, Zhengwei;Shi, Lai;Wang, Bo;He, Gang;Wang, Yanming;Chen, Gong. And the article was included in Science China: Chemistry in 2019.Safety of 2-Iodo-1H-pyrrolo[2,3-b]pyridine This article mentions the following:

A Cu-catalyzed C-H arylation reaction of N-heteroarene I [R = H; R¹ = H₃CO] has been applied to the synthesis of complex non-covalent PAD4 inhibitors I [R = 1-benzyl-1H-indol-2-yl, naphthalen-2-yl, pyrazin-2-yl, etc.; R¹ = (3S,4R)-3-amino-4-hydroxypiperidin-1-yl] bearing a bi-heteroaryl pharmacophore. This strategy access various analogs of C₂-aryl substituted benzimidazoles I [R¹ = OH, H₃CO] from a common benzimidazole core I [R = H; R¹ = H₃CO] and easily accessible aryl iodides RI. Preliminary SAR studies revealed that the indole motif of GSK-484 is critical to its activity. Replacing the N-cyclopropylmethyl group to N-benzyl group on the indole ring of GSK-484 resulted in more than 5-fold increase in cell killing efficacy against 4T1 cell line. In the experiment, the researchers used many compounds, for example, 2-Iodo-1H-pyrrolo[2,3-b]pyridine (cas: 1227270-32-7Safety of 2-Iodo-1H-pyrrolo[2,3-b]pyridine).

2-Iodo-1H-pyrrolo[2,3-b]pyridine (cas: 1227270-32-7) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Safety of 2-Iodo-1H-pyrrolo[2,3-b]pyridine

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The synthesis of natural acetylenic compounds from Eutypa lata (pers:F.) Tul was written by Defranq, Eric;Zesiger, Thierry;Tabacchi, Raffaele. And the article was included in Helvetica Chimica Acta in 1993.HPLC of Formula: 2314-37-6 This article mentions the following:

The synthesis of a series of novel acetylenic compounds I (R = CO₂H, CHO, CH₂OH; R¹ = OH, OMe), isolated recently from the fungus Eutypa lata, is described. The crucial step is the coupling reaction between a protected aryl halide and a cuprous acetylide. A more efficient method using Pd(PPh₃)₂Cl₂ as catalyst was also carried out with success. In the experiment, the researchers used many compounds, for example, 3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6HPLC of Formula: 2314-37-6).

3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.HPLC of Formula: 2314-37-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com