Adding a certain compound to certain chemical reactions, such as: 60166-93-0, name is Iopamidol, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 60166-93-0, Recommanded Product: 60166-93-0
Add iopamidol (Substance II) to 40 mL of anhydrous N,N-dimethylacetamide10.0 g, concentrated sulfuric acid 0.520 g,Then, a hydroxyl protective agent 2,2-dimethoxypropane 6.40 mL was added dropwise with stirring.The reaction temperature was maintained at about 55 C, and the reaction was stopped after stirring for 24 h.Neutralize the reaction solution with a sodium carbonate solution of 3% by mass.Most of the solvent was removed by rotary evaporation to give a pale yellow oil.150 mL of distilled water was added to the oil, stirred at room temperature for 2 h, and then centrifuged to obtain a white solid.It was washed twice with distilled water to remove unreacted raw materials and impurities.The obtained product was dried in a vacuum oven at 50 C to give 8.0 g of crude product.The crude product was purified by silica gel column chromatography (dichloromethane:methanol = 15:1)5 g of white compound III were obtained with a final yield of 45.6%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Iopamidol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Tianjin Medical University; Yang Xiaoying; Gao Chunhui; Zhang Yinghua; Wang Li; Xing Chao; Wang Yinsong; Chen Yan; (16 pag.)CN108452327; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com