These common heterocyclic compound, 811842-30-5, name is 2-Bromo-1-fluoro-4-iodobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 2-Bromo-1-fluoro-4-iodobenzene
Add 9H-purin-2-amine (135 mg, 1 mmol), 2-bromo-1-fluoro-4-iodobenzene (600 mg, 2 mmol), potassium carbonate (415 mg, 3 mmol) and proline(23 mg, 0.2 mmol) to the eggplant type flask, dimethyl sulfoxide was added, and the reaction solution was deoxidized. Copper iodide (19 mg, 0.1 mmol) was added and the reaction solution was deoxygenated. Heat to 90 C and stir for 16 hours. After the reaction was completed, it was cooled to room temperature, water and ethyl acetate were added, and the mixture was filtered over Celite.The target compound (QC87-1) 40 mg was obtained, ESI-MS calc. C11H779BrFN5[M+H]+= 307.99; experimentally measured: 307.39;the target compound (QC87-2) 40 mg was obtained.
The synthetic route of 2-Bromo-1-fluoro-4-iodobenzene has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Zhao Yujun; Li Zhiqiang; Yan Ziqin; Li Jia; Zhou Yubo; Su Mingbo; Chen Zheng; (138 pag.)CN109810110; (2019); A;,
Iodide – Wikipedia,
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