Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 69113-59-3, name is 3-Iodobenzonitrile, A new synthetic method of this compound is introduced below., Recommanded Product: 69113-59-3
General procedure: The coupling reaction was conducted under the same condition used for 1c. After the reaction was completed, the reaction mixture was cooled down to room temperature. To this mixture was added 10.0 mL of saturated NaHCO3 (aq) and then extracted with EtOAc (10 mL ¡Á 3). The combined organic solution was washed with brine, dried over anhydrous MgSO4, and purified by column chromatography (90/10 hexanes/EtOAc) to afford 0.25g of yellow oily liquid (2c) in 84% isolated yield; 1HNMR (500 MHz,CDCl3): delta =7.52 (d, J =8.5 Hz, 2H), 7.42 (d, J = 8.5 Hz, 2H), 5.00 (s, 1H), 3.40 (q, J = 7.5 Hz, 2H), 3.80 (q, J = 7.5 Hz, 2H), 2.16 (s, 2H), 1.26 (t, J = 7.5 Hz, 3H), 1.18 (t, J = 7.5 Hz, 3H) ppm. 13CNMR(125 MHz, CDCl3): delta = 169.31, 157.26, 138.19, 131.80, 127.93, 123.58, 84.56, 42.24, 40.24, 14.40, 13.64 ppm. HRMS (EI+): m/z calcd. for C13H17BrN2O: 296.0524, found 296.0499. IR (KBr): = 3379, 3273, 2973, 1608, 1590, 1478 cm-1. GC-MS (70 eV, EI+): m/z (%) = 296 ([M-H]+, 16), 226 (87), 224 (86), 197 (27), 117 (34), 72 (100).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Shin, Ueon Sang; Joo, Seong-Ryu; Kim, Seung-Hoi; Bulletin of the Korean Chemical Society; vol. 36; 10; (2015); p. 2565 – 2568;,
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