Adding a certain compound to certain chemical reactions, such as: 191348-14-8, name is 2-Iodo-4-methoxyaniline, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 191348-14-8, Formula: C7H8INO
To a solution of 2-iodo-4-methoxyaniline (0.42 g, 1.68 mol) in 1,4-dioxane (8.0 ml) are added PD (PH3P) 4 (0.195 g, 0. 168 mmol) and 2- (tributylstannyl) furan (0.63 ml, 2.0 MMOL). The reaction mixture is purged with argon and refluxed at 95oC for 3hr. The mixture is concentrated, diluted with hexane, extracted with CH3CN, and concentrated under vacuum. The residue is purified by silica gel chromatography (CH2C12) to afford 2- (2-furyl)-4-methoxyaniline as brown semi-solid 0.227 g (71%). HRMS (EI) calcd for CNHION02189. 0790, found 189.0794.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Iodo-4-methoxyaniline, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; PHARMACIA & UPJOHN COMPANY; WO2004/85433; (2004); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com