Synthetic Route of 31827-94-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 31827-94-8, name is 2-Bromo-1-(4-iodophenyl)ethanone, This compound has unique chemical properties. The synthetic route is as follows.
Into a 25 mL eggplant-shaped flask was added 1 mmol of N-(4-trifluoromethylphenyl)thiourea.1.05 mmol alpha-bromo-4-iodophenone,Add 10mL of ethanol to dissolve, add 1.5mmoL of triethylamine,Reflux reaction. After TLC tracks the reaction,The temperature of the reaction solution was lowered to room temperature, and the solvent was distilled off under reduced pressure.Column chromatography of the residue (eluent: petroleum ether-ethyl acetate) yields the target compound,White solid, yield 82%.
The chemical industry reduces the impact on the environment during synthesis 2-Bromo-1-(4-iodophenyl)ethanone. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Shanghai Pharmaceutical Industry Institute; East China University of Science and Technology; Chen Daijie; Xu Xiaoyong; Shao Lei; Li Zhong; Dong Xiaojing; Hou Shuang; Zhang Junliang; Wang Rong; (81 pag.)CN107629022; (2018); A;,
Iodide – Wikipedia,
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