Synthetic Route of 98-61-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 98-61-3 as follows.
General procedure: To a solution of pyrrolidine (0.5 mL) and DIPEA (0.5 mL) in 5 mL THF was added dropwise at 0 C a solution of 4-iodobenzenesulfonyl chloride (300 mg, 1 mmol) in THF (2 mL). The mixture was stirred overnight, diluted with ethyl acetate, washed with 1 N HCl solution and water, concentrated, and dried under vacuum. 1-(4-iodobenzenesulfonyl)pyrrolidine (310 mg, 92%) was obtained.
According to the analysis of related databases, 98-61-3, the application of this compound in the production field has become more and more popular.