Synthetic Route of 180624-10-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 180624-10-6, name is Methyl 4-amino-3-iodo-5-methoxybenzoate belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a solution of 94-1 (7.1 g, 23 mmol) in DCM (10 mL) was added BBr3 (3 mL) at 0 C. The mixture was stirred at 0 C. for 30 mins, and the reaction was quenched with aq. NaHCO3 (150 mL) and extracted with EA (300 mL). The organic layer was washed with brine (50 mL), dried over Na2SO4, filtered and concentrated. The residue was purified by column chromatography using 3080% EA in PE as eluent to give 94-2 (4.8 g, 71.3%) as a yellow oil. MS: m/z 293.8 [M+H]+.
The synthetic route of Methyl 4-amino-3-iodo-5-methoxybenzoate has been constantly updated, and we look forward to future research findings.