Adding a certain compound to certain chemical reactions, such as: 19094-56-5, name is 2-Chloro-5-iodobenzoic acid, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 19094-56-5, HPLC of Formula: C7H4ClIO2
General procedure: To a solution of the appropriate carboxylic acid (1.88 mmol) in anhydrous DMF (4 mL) were successively added, N,N’-dicyclohexylcarbodiimide (427 mg, 2.07 mmol) and 1-hydroxybenzotriazolehydrate (280 mg, 2.07 mmol) under argon. The reaction was stirred at room temperature for 30 min, and a solution of N,N-diethylethylenediamine (291 mL, 2.07 mmol) in distilled N,N-diisopropylethylamine (655 mL, 3.76 mmol) was added. The resulting mixture was stirred at room temperature for 16-21 h. After addition of water (15 mL), the solid was filtered off and washed with water (2 x 10 mL). The filtrates were pooled and extracted with ethyl acetate (4 x 40 mL). The combined organic layers were washed with a 5% aqueous sodium hydrogen carbonate solution (2 x 15 mL), dried over magnesium sulfate, filtered and evaporated under reduced pressure. The residue was purified by column chromatography on silica gel (dichloromethane/ethanol, 9/1, v/v).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Chloro-5-iodobenzoic acid, and friends who are interested can also refer to it.
Reference:
Article; Billaud, Emilie M.F.; Maisonial-Besset, Aurelie; Rbah-Vidal, Latifa; Vidal, Aurelien; Besse, Sophie; Bequignat, Jean-Baptiste; Decombat, Caroline; Degoul, Francoise; Audin, Laurent; Deloye, Jean-Bernard; Dolle, Frederic; Kuhnast, Bertrand; Madelmont, Jean-Claude; Tarrit, Sebastien; Galmier, Marie-Josephe; Borel, Michele; Auzeloux, Philippe; Miot-Noirault, Elisabeth; Chezal, Jean-Michel; European Journal of Medicinal Chemistry; vol. 92; (2015); p. 818 – 838;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com