Some common heterocyclic compound, 74534-15-9, name is 1-Chloro-2-iodo-4-nitrobenzene, molecular formula is C6H3ClINO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 74534-15-9
A mixture of compound 2 (10 mmol), iron powder (30 mmol) and saturated NH4Cl aqueous (10 mL) in EtOH (40 mL) was stirred at 75 C for 3 h. The reaction mixture was filtered through celite and the residue was washed with CH2Cl2. The filtrate was evaporated to remove most of EtOH, and then dissolved in CH2Cl2. The organic mixture was washed with water and brine, dried over Na2SO4, and condensed to give a yellow solid, yield 97%. 1H NMR (400 MHz, DMSO-d6) delta 7.14 (dd, J = 5.6, 3.0 Hz, 2H), 6.58 (dd, J = 8.6, 2.7 Hz, 1H), 5.42 (s, 2H). 13C NMR (101 MHz, DMSO) delta 149.28, 129.58, 124.68, 123.10, 115.86, 98.96.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 74534-15-9, its application will become more common.
Reference:
Article; Li, Wenlu; Sun, Qinsheng; Song, Lu; Gao, Chunmei; Liu, Feng; Chen, Yuzong; Jiang, Yuyang; European Journal of Medicinal Chemistry; vol. 141; (2017); p. 721 – 733;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com