Synthetic Route of 191348-14-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 191348-14-8 as follows.
Under anhydrous and anaerobic conditions, 0.1 mmol of 2-iodo-4-methoxyaniline was added.0.12 mmol of 3-methoxybenzaldehyde,0.3mmol selenium powder, 0.005mmol copper,0.2 mmol of potassium hydroxide and 10 ml of DMSO solution in a single-neck round bottom flask,The reaction was refluxed at 120 C, and the reaction was monitored by TLC.Separation of pure methoxy-containing benzoselenazole compounds by column chromatographyThe reaction product was obtained by demethylation of boron tribromide (6 eq.).The product was a white solid with a yield of 33%.
According to the analysis of related databases, 191348-14-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Wuhan University; Zhou Haibing; Zhang Silong; Hu Zhiye; Li Yuanyuan; Ning Wentao; Dong Chune; (13 pag.)CN108863985; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com